2019
Adolescent but not adult ethanol binge drinking modulates ethanol behavioral effects in mice later in life
Younis R, Wolstenholme J, Bagdas D, Bettinger J, Miles M, Damaj M. Adolescent but not adult ethanol binge drinking modulates ethanol behavioral effects in mice later in life. Pharmacology Biochemistry And Behavior 2019, 184: 172740. PMID: 31326461, PMCID: PMC6697373, DOI: 10.1016/j.pbb.2019.172740.Peer-Reviewed Original ResearchConceptsEthanol intakeEthanol drinkingEthanol's behavioral effectsEarly exposureAdolescent ethanol exposureEnhanced ethanol intakeAlcohol use disorderAnxiety-related behaviorAdolescence altersDrug-taking behaviorAlcohol intakeC57BL/6J miceEthanol exposureWithdrawal stateLong-term effectsNeurochemical mechanismsMouse modelBinge drinkingAdult miceUse disordersSerious illnessAbuse liabilityDrinking paradigmAdult exposureAdolescent population
2018
Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice
Kota D, Alajaji M, Bagdas D, Selley D, Sim-Selley L, Damaj M. Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice. Pharmacology Biochemistry And Behavior 2018, 173: 58-64. PMID: 30125591, PMCID: PMC6160313, DOI: 10.1016/j.pbb.2018.08.006.Peer-Reviewed Original ResearchConceptsMorphine rewardAdult miceG-protein activityNicotine exposurePhysical dependenceEarly adolescent nicotine exposureAdolescent nicotine treatmentMu-opioid receptor activityAdolescent nicotine exposureCurrent opioid crisisSomatic withdrawal signsMorphine physical dependenceDrug-taking behaviorNicotine treatmentWithdrawal signsWithdrawal symptomsMale miceLong-term effectsLow doseNicotine productsCPP testOpioid crisisReceptor activitySubstance abuseMice