2020
Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
Bagdas D, Gul Z, Meade JA, Cam B, Cinkilic N, Gurun MS. Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation. Current Neuropharmacology 2020, 18: 216-228. PMID: 31631820, PMCID: PMC7327949, DOI: 10.2174/1570159x17666191021111809.Peer-Reviewed Original ResearchConceptsLiterature searchElectronic literature searchDifferent pathological situationsChlorogenic acidPharmacologic overviewNeuropathic painPain managementChronic painInflammatory insultPreventive roleAnimal modelsInflammationPotent antioxidantCertain foodsOxidative stressEthnopharmacological reportsPutative mechanismsDietary plantsAntioxidant defenseNatural phenolic compoundsPathological situationsPainMedicinal herbsOriginal articlesPhenolic compounds
2016
Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats
Bagdas D, Etoz B, Gul Z, Ozyigit M, Cinkilic N, Inan S, Buyukcoskun N, Ozluk K, Gurun M. Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats. Annals Of Plastic Surgery 2016, 77: e21-e25. PMID: 25356637, DOI: 10.1097/sap.0000000000000313.Peer-Reviewed Original ResearchConceptsFlap survivalDiabetic ratsEpigastric arteryFlap tissueMg/0.5 mLEffects of CGASkin flap survivalPostoperative day 7Abdominal skin flapSkin flap modelGreater flap survivalChlorogenic acidCGA treatmentFemoral arteryLocal injectionAntioxidant activitySingle arteryCapillary densityDismutase levelsMalondialdehyde levelsSkin flapsDay 7ArteryFlap modelRatsProtective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol
Gul Z, Demircan C, Bagdas D, Buyukuysal R. Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol. Neurochemical Research 2016, 41: 2075-2085. PMID: 27161374, DOI: 10.1007/s11064-016-1919-8.Peer-Reviewed Original ResearchConceptsOxidative stress parametersCortical slicesRat brain slicesRat cortical slicesStress parametersChlorogenic acidChloride stainingProtective effectBrain slicesOxidative stressQuinic acidResveratrolNatural phenolic compoundsMain metaboliteMalondialdehydeCaffeic acidROS levelsIncubation mediumPhenolic compoundsAlterationsIC50 valuesPresent studyStainingΜM H2O2Oxygen species
2015
In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile
Bagdas D, Etoz B, Gul Z, Ziyanok S, Inan S, Turacozen O, Gul N, Topal A, Cinkilic N, Tas S, Ozyigit M, Gurun M. In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile. Food And Chemical Toxicology 2015, 81: 54-61. PMID: 25846499, DOI: 10.1016/j.fct.2015.04.001.Peer-Reviewed Original ResearchConceptsSide effectsOxidative stressStreptozotocin-induced diabetic ratsChronic antioxidant treatmentEndogenous antioxidant defense systemNitric oxide levelsWound healingBlood glucose levelsSystemic antioxidant therapyDays of treatmentPossible side effectsDiabetic wound repairLipid peroxidation levelsChlorogenic acidAcid therapyDiabetic ratsHistopathological examinationPossible pro-oxidative effectsPro-oxidative effectsAntioxidant intakePivotal organAntioxidant therapyDiabetic conditionsAntioxidant balanceGlucose levels
2014
Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing
Bagdas D, Gul N, Topal A, Tas S, Ozyigit M, Cinkilic N, Gul Z, Etoz B, Ziyanok S, Inan S, Turacozen O, Gurun M. Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing. Naunyn-Schmiedeberg's Archives Of Pharmacology 2014, 387: 1101-1116. PMID: 25129377, DOI: 10.1007/s00210-014-1034-9.Peer-Reviewed Original ResearchConceptsSide effectsWound healingHigh doseBone marrowEffects of CGAAnti-inflammatory effectsDietary chlorogenic acidNitric oxide levelsMatrix metalloproteinase-9Oxidative stress markersPossible side effectsDose-dependent mannerChlorogenic acidCGA supplementationPharmacologic overviewFree radical scavengerAcid therapyCGA treatmentLeukocyte infiltrationPivotal organImmunohistochemical examinationRat bone marrowMetalloproteinase-9Oxide levelsStress markersAntinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy
Bagdas D, Ozboluk H, Cinkilic N, Gurun M. Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy. Journal Of Medicinal Food 2014, 17: 730-732. PMID: 24611441, DOI: 10.1089/jmf.2013.2966.Peer-Reviewed Original ResearchConceptsDiabetic neuropathic painAntinociceptive effectNeuropathic painChronic treatmentPainful diabetic neuropathyPossible antinociceptive effectSignificant antinociceptive effectChlorogenic acid treatmentChlorogenic acidDiabetic neuropathyNondiabetic ratsDiabetic ratsSingle doseAntinociceptive potentialRatsBeneficial effectsPainTreatmentPresent studyNeuropathyStreptozotocinHyperglycemiaDiabetesDose
2013
Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats
Bagdas D, Etoz B, Ozturkoglu S, Cinkilic N, Ozyigit M, Gul Z, Buyukcoskun N, Ozluk K, Gurun M. Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats. Biological And Pharmaceutical Bulletin 2013, 37: 361-370. PMID: 24389556, DOI: 10.1248/bpb.b13-00635.Peer-Reviewed Original ResearchConceptsSkin flap survivalFlap survivalDiabetic ratsNondiabetic ratsCapillary densityBlood perfusionVascular endothelial growth factor (VEGF) expressionPostoperative day 7Nitric oxide levelsMale Wistar ratsDorsal skin flapDorsal skin flap modelSkin flap modelGrowth factor expressionPotent antioxidant effectsChlorogenic acidRegional blood perfusionCGA treatmentWistar ratsSOD levelsOxide levelsSkin flapsNO levelsFlap tissueDay 7
2012
Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain
Bagdas D, Cinkilic N, Ozboluk H, Ozyigit M, Gurun M. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. Journal Of Natural Medicines 2012, 67: 698-704. PMID: 23203628, DOI: 10.1007/s11418-012-0726-z.Peer-Reviewed Original ResearchConceptsChronic constrictive nerve injuryNeuropathic painAntihyperalgesic activityPeripheral neuropathic pain modelExperimental neuropathic painNeuropathic pain modelRota-rod testNovel potential therapeutic optionPotential therapeutic optionStrong therapeutic effectLatency of ratsChlorogenic acidAntihyperalgesic effectMechanical hyperalgesiaNerve injuryPain modelChronic administrationInflammatory cascadeTherapeutic optionsHistopathological changesInflammatory processTherapeutic effectAnalgesic activityPainNervous system