2017
Minimal effects of prolonged smoking abstinence or resumption on cognitive performance challenge the “self-medication” hypothesis in schizophrenia
Boggs DL, Surti TS, Esterlis I, Pittman B, Cosgrove K, Sewell RA, Ranganathan M, D'Souza DC. Minimal effects of prolonged smoking abstinence or resumption on cognitive performance challenge the “self-medication” hypothesis in schizophrenia. Schizophrenia Research 2017, 194: 62-69. PMID: 28392208, PMCID: PMC5630481, DOI: 10.1016/j.schres.2017.03.047.Peer-Reviewed Original ResearchConceptsProcessing speedMultiple cognitive domainsCognitive test performancePro-cognitive effectsSelf-medication hypothesisNicotine-dependent smokersVerbal memoryVerbal recallCognitive batteryCognitive domainsExecutive functionVerbal fluencyBehavioral measuresTest batteryCognitive deficitsTest performanceSmoking cessationSmoking abstinenceNegative symptomsConflict resolutionAbstinenceCognitionDepressive symptomsSchizophreniaSmoke cigarettes
2013
Effect of a Nicotine Vaccine on Nicotine Binding to β2*-Nicotinic Acetylcholine Receptors In Vivo in Human Tobacco Smokers
Esterlis I, Hannestad JO, Perkins E, Bois F, D’Souza D, Tyndale RF, Seibyl JP, Hatsukami DM, Cosgrove KP, O’Malley S. Effect of a Nicotine Vaccine on Nicotine Binding to β2*-Nicotinic Acetylcholine Receptors In Vivo in Human Tobacco Smokers. American Journal Of Psychiatry 2013, 170: 399-407. PMID: 23429725, PMCID: PMC3738000, DOI: 10.1176/appi.ajp.2012.12060793.Peer-Reviewed Original ResearchConceptsNicotine vaccineNicotinic acetylcholine receptorsNicotine bindingAmount of nicotineAcetylcholine receptorsHuman tobacco smokersSingle photon emissionTobacco smokersNicotine promotesScan daySmokers' brainsIntravenous administrationEmission scansNicotine dependenceSPECT scansSubcortical regionsNAChRsNicotineImmunizationVT/VaccineCigarettesBrainCessation difficultiesSmokers
2012
Lower β2*-Nicotinic Acetylcholine Receptor Availability in Smokers With Schizophrenia
D'Souza DC, Esterlis I, Carbuto M, Krasenics M, Seibyl J, Bois F, Pittman B, Ranganathan M, Cosgrove K, Staley J. Lower β2*-Nicotinic Acetylcholine Receptor Availability in Smokers With Schizophrenia. American Journal Of Psychiatry 2012, 169: 326-334. PMID: 22193533, PMCID: PMC3881431, DOI: 10.1176/appi.ajp.2011.11020189.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptor availabilityNicotinic acetylcholine receptorsReceptor availabilityNegative symptomsAcetylcholine receptorsNicotinic acetylcholine receptor systemHealthy tobacco smokersAcetylcholine receptor systemDevelopment of medicationsSingle photon emissionIA-85380Agonist radiotracerTobacco smokersCigarette smokingAvailability of receptorsSmoking abstinenceNicotine actionPostmortem studiesFrontal cortexSmokersSmokingVivo findingsParietal cortexReceptor systemSymptoms