Effect of a Nicotine Vaccine on Nicotine Binding to β2*-Nicotinic Acetylcholine Receptors In Vivo in Human Tobacco Smokers
Esterlis I, Hannestad JO, Perkins E, Bois F, D’Souza D, Tyndale RF, Seibyl JP, Hatsukami DM, Cosgrove KP, O’Malley S. Effect of a Nicotine Vaccine on Nicotine Binding to β2*-Nicotinic Acetylcholine Receptors In Vivo in Human Tobacco Smokers. American Journal Of Psychiatry 2013, 170: 399-407. PMID: 23429725, PMCID: PMC3738000, DOI: 10.1176/appi.ajp.2012.12060793.Peer-Reviewed Original ResearchConceptsNicotine vaccineNicotinic acetylcholine receptorsNicotine bindingAmount of nicotineAcetylcholine receptorsHuman tobacco smokersSingle photon emissionTobacco smokersNicotine promotesScan daySmokers' brainsIntravenous administrationEmission scansNicotine dependenceSPECT scansSubcortical regionsNAChRsNicotineImmunizationVT/VaccineCigarettesBrainCessation difficultiesSmokers