2017
Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information
Ranganathan M, Radhakrishnan R, Addy PH, Schnakenberg-Martin AM, Williams AH, Carbuto M, Elander J, Pittman B, Sewell R, Skosnik PD, D'Souza DC. Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 79: 176-183. PMID: 28642081, DOI: 10.1016/j.pnpbp.2017.06.019.Peer-Reviewed Original ResearchConceptsRey Auditory Verbal Learning TestVerbal informationInfluence of tetrahydrocannabinolVerbal Learning TestMemory-impairing effectsTotal immediate recallNon-verbal informationImpairs memory consolidationAdministration of tetrahydrocannabinolAcute memory impairmentPrincipal psychoactive constituentVerbal memoryImmediate recallIntravenous tetrahydrocannabinolLearning TestMemory consolidationComponent processesNeural synchronyMemory impairmentInformation processingUse of cannabisCannabis intoxicationRecallPsychoactive constituentEncoding
2012
Feasibility, Safety, and Efficacy of the Combination of D-Serine and Computerized Cognitive Retraining in Schizophrenia: An International Collaborative Pilot Study
D'Souza DC, Radhakrishnan R, Perry E, Bhakta S, Singh NM, Yadav R, Abi-Saab D, Pittman B, Chaturvedi SK, Sharma MP, Bell M, Andrade C. Feasibility, Safety, and Efficacy of the Combination of D-Serine and Computerized Cognitive Retraining in Schizophrenia: An International Collaborative Pilot Study. Neuropsychopharmacology 2012, 38: 492-503. PMID: 23093223, PMCID: PMC3547200, DOI: 10.1038/npp.2012.208.Peer-Reviewed Original ResearchConceptsCognitive retrainingCognitive deficitsVerbal Working MemoryCognitive remediation strategiesAttention/vigilanceBasic information processingIndividual test performanceGlobal cognitive indexWorking memoryD-serineCognitive indicesCombination of pharmacotherapyTest performanceInformation processingMulticenter international clinical trialParallel group designSchizophrenia subjectsCollaborative pilot studyInternational clinical trialsUS samplePreliminary findingsCombination pharmacotherapySchizophreniaClinical trialsOutcome measuresDose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans
D'Souza DC, Fridberg DJ, Skosnik PD, Williams A, Roach B, Singh N, Carbuto M, Elander J, Schnakenberg A, Pittman B, Sewell RA, Ranganathan M, Mathalon D. Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans. Neuropsychopharmacology 2012, 37: 1632-1646. PMID: 22334121, PMCID: PMC3358754, DOI: 10.1038/npp.2012.8.Peer-Reviewed Original ResearchConceptsRecent cannabis usersPerceptual alterationsERP componentsCannabis usersEvent-related potential taskSensory ERP componentsCannabis Use StatusModulation of eventsΔ9-THCProperties of cannabisContext updatingNeural correlatesP3b amplitudeTarget stimuliPsychophysiological indicesCortical processesP300b amplitudesProcessing speedCognitive deficitsPsychophysiological dataInformation processingAutomatic orientationCounterbalanced designSubjective effectsPotential tasks
2000
The Emerging Neurobiology of Dissociative States
Krystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. Springer Series On Stress And Coping 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.Peer-Reviewed Original ResearchPerceptual alterationsFocusing of attentionCognitive processesDistorts perceptionsPerceptual distortionReduced processingInformation processingPeripheral stimuliProlonged sensory deprivationSensory perceptionSensory deprivationPerceptionEveryday lifeDissociative statesExact transcriptionProcessingDepersonalizationMemoryIllusionNeurobiologyStimuliDerealizationHallucinationsAttentionPeople