2018
The Association Between Cannabinoids and Psychosis
Tikka S, D’Souza D. The Association Between Cannabinoids and Psychosis. 2018, 127-155. DOI: 10.1007/978-3-319-90365-1_14.Peer-Reviewed Original ResearchChronic psychotic disordersPsychotic disordersClinical interventionsPsychosis outcomesEmergency department visitsOnset of psychosisPotent synthetic cannabinoidCannabinoid receptor agonistsSignificant clinical interventionHigh rateDuration of intoxicationCannabinoid exposureDepartment visitsCumulative doseReceptor agonistCannabinoid hypothesisClinical significancePeriod of intoxicationCannabinoid productsCannabis useEarly onsetPsychosisPotency of cannabisCannabinoidsRecreational cannabisRevisiting the Consequences of Adolescent Cannabinoid Exposure Through the Lens of the Endocannabinoid System
Ganesh S, Vidya K, Rashid A, Singh J, D’Souza D. Revisiting the Consequences of Adolescent Cannabinoid Exposure Through the Lens of the Endocannabinoid System. Current Addiction Reports 2018, 5: 418-427. DOI: 10.1007/s40429-018-0233-8.Peer-Reviewed Original ResearchAdolescent cannabinoid exposureCannabinoid exposureEndocannabinoid systemHuman studiesAdolescent cannabis exposurePersistent consequencesPatterns of cannabisPotential molecular mechanismsExogenous cannabinoidsCannabis exposureSynaptic potentiationAnimal modelsAdolescent exposureConflicting resultsNeurodevelopmentExposureCannabinoidsMolecular mechanismsPlausible linkRecent studiesPersistent effectsCompelling evidenceCognitive consequencesFurther researchEpigenetic mechanismsThe Psychiatric Consequences of Cannabinoids
De Aquino JP, Sherif M, Radhakrishnan R, Cahill JD, Ranganathan M, D'Souza D. The Psychiatric Consequences of Cannabinoids. Clinical Therapeutics 2018, 40: 1448-1456. PMID: 29678279, DOI: 10.1016/j.clinthera.2018.03.013.Peer-Reviewed Original ResearchConceptsPsychiatric effectsPsychiatric disordersPre-existing psychiatric disordersCannabis useLong-term brain changesRates of cannabisNegative psychiatric outcomesNegative psychiatric effectsDose-dependent effectPublic mental healthCannabinoid exposureWithdrawal syndromeCannabis exposureAcute effectsBrain changesMood disordersPsychiatric outcomesGeneral populationPsychomotor functionHealthy individualsMedical cannabisPsychiatric consequencesChronic exposureSignificant impairmentMental health
2016
A Systematic Review of the Evidence for Medical Marijuana in Psychiatric Indications.
Wilkinson ST, Radhakrishnan R, D'Souza DC. A Systematic Review of the Evidence for Medical Marijuana in Psychiatric Indications. The Journal Of Clinical Psychiatry 2016, 77: 1050-64. PMID: 27561138, DOI: 10.4088/jcp.15r10036.BooksConceptsEfficacy of marijuanaPosttraumatic stress disorderPsychiatric indicationsStrength of evidenceTourette's disorderPsychiatric conditionsSystematic reviewAlzheimer's diseaseChronic cannabinoid exposureEfficacy of cannabinoidsUse of cannabinoidsAbsence of RCTsMedical marijuanaEmergence of psychosisLow-quality studiesBest available evidenceSafety of marijuanaPersistent marijuana useCannabinoid exposureClinical trialsPRISMA guidelinesSide effectsSpecific diagnosisGRADE methodsConstituent cannabinoids
2014
Chapter Fourteen Cannabis, Cannabinoids, and the Association with Psychosis
Radhakrishnan R, Addy P, Sewell R, Skosnik P, Ranganathan M, D’Souza D. Chapter Fourteen Cannabis, Cannabinoids, and the Association with Psychosis. 2014, 423-474. DOI: 10.1016/b978-0-12-418679-8.00014-9.Peer-Reviewed Original ResearchPsychotic disordersCannabis exposureComponent causesCannabinoid receptor functionDevelopment of schizophreniaHeavy cannabis exposurePublic health policyCannabinoid exposureTrigger relapsePsychophysiological deficitsCognitive symptomsReceptor functionSchizophreniaHealth policyCannabinoidsPsychosisCannabisLines of evidenceDisordersFurther studiesSymptomsBiological mechanismsExposureIndividual vulnerabilityCause
2010
Efeitos comportamentais, cognitivos e psicofisiológicos dos canabinoides: relevância para a psicose e a esquizofrenia
Sewell RA, Skosnik PD, Garcia-Sosa I, Ranganathan M, D'Souza DC. Efeitos comportamentais, cognitivos e psicofisiológicos dos canabinoides: relevância para a psicose e a esquizofrenia. Brazilian Journal Of Psychiatry 2010, 32: 515-530. PMID: 20512267, DOI: 10.1590/s1516-44462010000500005.Peer-Reviewed Original ResearchConceptsPsychotic disordersCannabis exposureComponent causesCannabinoid receptor functionCauses of schizophreniaHeavy cannabis exposurePublic health policyCannabinoid exposureTrigger relapsePsychophysiological deficitsCognitive symptomsReceptor functionSchizophreniaHealth policyCannabinoidsLines of evidenceDisordersFurther studiesCannabisSymptomsPsychosisBiological mechanismsExposureIndividual vulnerabilityCause
2009
Cannabis and psychosis/schizophrenia: human studies
D’Souza D, Sewell RA, Ranganathan M. Cannabis and psychosis/schizophrenia: human studies. European Archives Of Psychiatry And Clinical Neuroscience 2009, 259: 413-431. PMID: 19609589, PMCID: PMC2864503, DOI: 10.1007/s00406-009-0024-2.Peer-Reviewed Original ResearchConceptsPsychotic disordersRole of cannabinoidsPsychosis/schizophreniaTransient psychotic symptomsComponent causesCannabinoid receptor functionCauses of schizophreniaWarrants further studyDuration of exposureCannabinoid exposureTrigger relapsePsychotic illnessPsychotic symptomsGeneral populationCognitive symptomsHealthy individualsHuman studiesReceptor functionCannabis useNeurodevelopmental processesCannabinoidsFirst exposureSymptomsDisordersGenetic factors