2014
The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults
Farr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults. Experimental And Clinical Psychopharmacology 2014, 22: 154-165. PMID: 24188171, PMCID: PMC4105943, DOI: 10.1037/a0034465.Peer-Reviewed Original ResearchConceptsStop-signal taskSalient stimuliSaliency processingFunctional MRIAttention deficit hyperactivity disorderRight inferior parietal cortexHigh motivational valueDeficit hyperactivity disorderEffects of methylphenidateInferior parietal cortexHealthy adultsNeural basisCognitive functioningMotivational valueAttention disordersHyperactivity disorderBilateral caudate headCatecholaminergic signalingMethylphenidate groupParietal cortexCerebral activationHigher activationCatecholaminergic treatmentPrimary motor cortexCerebral activity
2013
Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCerebral CortexCocaine-Related DisordersCognition DisordersFemaleHumansImage Processing, Computer-AssistedInhibition, PsychologicalMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedModels, NeurologicalNeural PathwaysNeuropsychological TestsOxygenPhotic StimulationReaction TimeConceptsFunctional magnetic resonance imagingStop-signal taskCD individualsCerebral activationPrecuneus/posterior cingulate cortexSystolic blood pressureInfluence of methylphenidateEffects of methylphenidateMagnetic resonance imagingPosterior cingulate cortexBrain imaging studiesCocaine-addicted individualsDefault mode networkAgonist therapyBlood pressureIntravenous methylphenidateCortico-striatoHealthy controlsCocaine-dependent individualsThalamic activationCingulate cortexResonance imagingBrain regionsMethylphenidateCocaine dependence
2010
Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14455-14459. PMID: 20660731, PMCID: PMC2922598, DOI: 10.1073/pnas.1002467107.Peer-Reviewed Original ResearchConceptsMiddle frontal cortexStop-signal reaction timeCocaine-dependent patientsWhole-brain linear regressionLonger stop-signal reaction timesFunctional MRI studyInhibitory controlInhibition-related activationBlood pressureIntravenous methylphenidatePeripheral biomarkersSignal reaction timeFrontal cortexStop-signal taskIndividualized treatmentHealthy individualsMRI studiesVentromedial prefrontal cortexSpecific neural mechanismsCocaine dependenceBiological markersPrefrontal cortexPatientsMethylphenidate responseSignal task