Genetic contributions to anxiety disorders: where we are and where we are heading
Ask H, Cheesman R, Jami ES, Levey DF, Purves KL, Weber H. Genetic contributions to anxiety disorders: where we are and where we are heading. Psychological Medicine 2021, 51: 2231-2246. PMID: 33557968, DOI: 10.1017/s0033291720005486.Peer-Reviewed Original ResearchMeSH KeywordsAnxiety DisordersComorbidityGene-Environment InteractionGenome-Wide Association StudyGenomicsHumansPanic DisorderPhenotypeRisk FactorsTwin Studies as TopicConceptsLarge-scale genome-wide association studiesGenome-wide association studiesGenetics of anxietyGenome-wide studiesRelated traitsAssociation studiesGeneticsGenetic contributionSpecific gene-environment interactionsGene-environment interactionsCurrent knowledgeTraitsNew therapeuticsSuch discoveriesDiscoveryNew research possibilitiesLifespanTherapeuticsCircuit mechanismsTranslationMulti-environment gene interactions linked to the interplay between polysubstance dependence and suicidality
Polimanti R, Levey DF, Pathak GA, Wendt FR, Nunez YZ, Ursano RJ, Kessler RC, Kranzler HR, Stein MB, Gelernter J. Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality. Translational Psychiatry 2021, 11: 34. PMID: 33431810, PMCID: PMC7801457, DOI: 10.1038/s41398-020-01153-1.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremChromosomal Proteins, Non-HistoneGene-Environment InteractionHumansRisk AssessmentRisk FactorsSuicidal IdeationSuicideTobacco Use DisorderConceptsSuicidal ideationPolysubstance dependenceSuicide attemptsOdds ratioGene-environment interactionsYale-PennMultivariate logistic regressionImportant risk factorMultivariate gene-environment interactionsMental health risksOpioid dependenceRisk factorsNicotine dependenceSuicidality outcomesCocaine dependenceLogistic regressionSubstance dependenceSuicidalityCohortLifetime suicidalityLinear mixed modelsMultiple substancesArmy STARRSArmy personnelHealth risks