2021
Within-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes
Maisto SA, Hallgren KA, Swan JE, Roos C, Witkiewitz K. Within-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes. Drug And Alcohol Dependence 2021, 228: 108968. PMID: 34560333, PMCID: PMC11170462, DOI: 10.1016/j.drugalcdep.2021.108968.Peer-Reviewed Original ResearchConceptsLong-term outcomes
2020
Patterns of Transitions Between Relapse to and Remission From Heavy Drinking Over the First Year After Outpatient Alcohol Treatment and Their Relation to Long-Term Outcomes
Maisto SA, Hallgren KA, Roos CR, Swan JE, Witkiewitz K. Patterns of Transitions Between Relapse to and Remission From Heavy Drinking Over the First Year After Outpatient Alcohol Treatment and Their Relation to Long-Term Outcomes. Journal Of Consulting And Clinical Psychology 2020, 88: 1119-1132. PMID: 33370135, PMCID: PMC7900838, DOI: 10.1037/ccp0000615.Peer-Reviewed Original ResearchConceptsLong-term outcomesHeavy drinkingBetter long-term outcomesAlcohol use disorder treatmentRemission/relapsePattern of remissionOutpatient alcohol treatmentUse disorder treatmentFirst yearContinuous relapseContinuous remissionMore relapsesClinical courseOutpatient treatmentRemissionDrinking statusLong-term recoveryRelapsePosttreatment periodDisorder treatmentAlcohol treatmentRelapse episodesAverage durationFunctioning outcomesHeavy drinking statusCan Individuals With Alcohol Use Disorder Sustain Non-abstinent Recovery? Non-abstinent Outcomes 10 Years After Alcohol Use Disorder Treatment
Witkiewitz K, Wilson AD, Roos CR, Swan JE, Votaw VR, Stein ER, Pearson MR, Edwards KA, Tonigan JS, Hallgren KA, Montes KS, Maisto SA, Tucker JA. Can Individuals With Alcohol Use Disorder Sustain Non-abstinent Recovery? Non-abstinent Outcomes 10 Years After Alcohol Use Disorder Treatment. Journal Of Addiction Medicine 2020, 15: 303-310. PMID: 33060466, PMCID: PMC8044251, DOI: 10.1097/adm.0000000000000760.Peer-Reviewed Original ResearchEvaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes
Roos CR, Kiluk BD, McHugh RK, Carroll KM. Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes. Psychology Of Addictive Behaviors 2020, 34: 660-668. PMID: 32297754, PMCID: PMC7483283, DOI: 10.1037/adb0000581.Peer-Reviewed Original ResearchConceptsIllicit opioid useOpioid useDepressive symptomsUse disordersSubstance use outcomesMethadone treatmentStandard methadone treatmentTrial of galantamineUse outcomesOpioid use disorderSubstance Use Treatment OutcomesSubstance use disordersCocaine use disorderCognitive behavioral therapyLongitudinal treatment studyTreatment outcomesPredictors of endPosttreatment outcomesSymptomsTreatment studiesSignificant total effectSubstance useBaselineOutcomesDisordersShort- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders
Roos CR, Carroll KM, Nich C, Frankforter T, Kiluk BD. Short- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders. Drug And Alcohol Dependence 2020, 212: 108044. PMID: 32422538, PMCID: PMC7293942, DOI: 10.1016/j.drugalcdep.2020.108044.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyPerson cognitive-behavioural therapySubstance use disordersMediation effectAlcohol use disorderComputer-delivered cognitive behavioural therapyUse disordersSame mediation effectSubstance-related copingCoping Strategies ScaleSignificant mediation effectMechanisms of changeMediational modelCoping skillsStrategies ScaleCBT4CBTStatistical mediatorCopingDrug use disordersSubstance useHeavy drinkingDisordersLong-term changesLong-term increase
2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchAdvancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response
Witkiewitz K, Roos CR, Mann K, Kranzler HR. Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response. Alcohol Clinical And Experimental Research 2019, 43: 2395-2405. PMID: 31436886, PMCID: PMC6824945, DOI: 10.1111/acer.14183.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DeterrentsAlcohol DrinkingAlcoholismFemaleHumansMaleMiddle AgedNaltrexonePrecision MedicineRewardTreatment OutcomeConceptsEffects of naltrexoneHeavy drinking daysAlcohol use disorderDaily naltrexoneUse disordersDrinking daysDaily drinkingPercent heavy drinking daysPrecision medicinePrecision medicine approachDaily medicationNaltrexone responseInteractive voice response technologyClinical trialsNaltrexone effectsRewarding effectsSpecific treatmentNaltrexoneSecondary analysisMedicine approachDrinkersProblem drinkersReward drinkersPlaceboDrinkingChange in employment status and cocaine use treatment outcomes: A secondary analysis across six clinical trials
Miguel AQC, Kiluk BD, Roos CR, Babuscio TA, Nich C, Mari JJ, Carroll KM. Change in employment status and cocaine use treatment outcomes: A secondary analysis across six clinical trials. Journal Of Substance Use And Addiction Treatment 2019, 106: 89-96. PMID: 31540616, PMCID: PMC6785033, DOI: 10.1016/j.jsat.2019.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultCocaine-Related DisordersEmploymentFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicTreatment OutcomeUnemploymentConceptsTreatment outcomesPatterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning.
Roos CR, Nich C, Mun CJ, Mendonca J, Babuscio TA, Witkiewitz K, Carroll KM, Kiluk BD. Patterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning. Journal Of Studies On Alcohol And Drugs 2019, 80: 431-440. PMID: 31495380, PMCID: PMC6739643, DOI: 10.15288/jsad.2019.80.431.Peer-Reviewed Original Research
2018
Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment
Witkiewitz K, Kirouac M, Roos CR, Wilson AD, Hallgren KA, Bravo AJ, Montes KS, Maisto SA. Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment. Psychology Of Addictive Behaviors 2018, 32: 639-646. PMID: 30160499, PMCID: PMC6136973, DOI: 10.1037/adb0000381.Peer-Reviewed Original ResearchConceptsLow-risk drinkingRisk drinkingHeavy drinkingDrinking daysAlcohol-related consequencesAlcohol usePersistent heavy drinkingWeeks of treatmentOutcomes 3 yearsDrinking outcomesHeavy drinking daysLow-risk drinkersAlcohol use disorderMeasures latent class analysisOutpatient armRisk drinkersOutcome measuresHeavy drinking episodesLower riskUse disordersHeavy drinkersFunctioning outcomesPsychosocial functioningAbstinenceDrinking episodesProfiles of recovery from alcohol use disorder at three years following treatment: can the definition of recovery be extended to include high functioning heavy drinkers?
Witkiewitz K, Wilson AD, Pearson MR, Montes KS, Kirouac M, Roos CR, Hallgren KA, Maisto SA. Profiles of recovery from alcohol use disorder at three years following treatment: can the definition of recovery be extended to include high functioning heavy drinkers? Addiction 2018, 114: 69-80. PMID: 30063267, PMCID: PMC6289769, DOI: 10.1111/add.14403.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAlcohol AbstinenceAlcoholics AnonymousAlcoholismCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansLatent Class AnalysisMaleMental HealthMental Health RecoveryMiddle AgedMotivational InterviewingPersonal SatisfactionSocial BehaviorTreatment OutcomeUnemploymentConceptsOccasional heavy drinkersAlcohol use disorderHeavy drinkersNon-heavy drinkersUse disordersPsychosocial functioningSecondary analysisMental healthInfrequent heavy drinkersTreatment-related variablesRandomized clinical trialsAlcoholics Anonymous (AA) involvementFrequent heavy drinkersPost-treatment abstinenceProfiles of recoveryClinical trialsDefinition of recoveryAlcohol-related problemsAlcohol dependence severityDrug useAlcohol useRecovery outcomesHeavy drinkingDrinkersDependence severityCourse of remission from and relapse to heavy drinking following outpatient treatment of alcohol use disorder
Maisto SA, Hallgren KA, Roos CR, Witkiewitz K. Course of remission from and relapse to heavy drinking following outpatient treatment of alcohol use disorder. Drug And Alcohol Dependence 2018, 187: 319-326. PMID: 29705545, PMCID: PMC5959805, DOI: 10.1016/j.drugalcdep.2018.03.011.Peer-Reviewed Original ResearchRace/ethnicity and racial group composition moderate the effectiveness of mindfulness-based relapse prevention for substance use disorder
Greenfield BL, Roos C, Hagler KJ, Stein E, Bowen S, Witkiewitz KA. Race/ethnicity and racial group composition moderate the effectiveness of mindfulness-based relapse prevention for substance use disorder. Addictive Behaviors 2018, 81: 96-103. PMID: 29454179, PMCID: PMC5860666, DOI: 10.1016/j.addbeh.2018.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlaska NativesAsianBlack or African AmericanCognitive Behavioral TherapyEthnicityFemaleHispanic or LatinoHumansIndians, North AmericanMaleMiddle AgedMindfulnessNative Hawaiian or Other Pacific IslanderPsychotherapy, GroupSecondary PreventionSubstance-Related DisordersTreatment OutcomeWhite People
2017
Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes
Mann K, Roos CR, Hoffmann S, Nakovics H, Leménager T, Heinz A, Witkiewitz K. Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes. Neuropsychopharmacology 2017, 43: 891-899. PMID: 29154368, PMCID: PMC5809801, DOI: 10.1038/npp.2017.282.Peer-Reviewed Original ResearchConceptsBetter treatment responseAlcohol dependenceTreatment responsePREDICT studyAnalysis of subgroupsSubgroup of individualsRelief scoresActive medicationRandomized trialsAD patientsSelf-report questionnairesMedicationsNaltrexonePharmacotherapy responseHigher effect sizesHeavy drinkingClinical applicabilityCutoff analysisDrinking phenotypesPlaceboPrecision medicineDrinkersPatientsEffect sizeDrinkingBaseline Patterns of Substance Use Disorder Severity and Depression and Anxiety Symptoms Moderate the Efficacy of Mindfulness-Based Relapse Prevention
Roos CR, Bowen S, Witkiewitz K. Baseline Patterns of Substance Use Disorder Severity and Depression and Anxiety Symptoms Moderate the Efficacy of Mindfulness-Based Relapse Prevention. Journal Of Consulting And Clinical Psychology 2017, 85: 1041-1051. PMID: 29083220, PMCID: PMC5679292, DOI: 10.1037/ccp0000249.Peer-Reviewed Original ResearchConceptsMindfulness-based relapse preventionSubstance use disordersSUD severityAnxiety symptomsRelapse preventionSUD symptomsSubstance use outcomesCognitive-behavioral relapse preventionOptimal treatmentUse disordersDepression symptomsSymptomsSymptom severityUse outcomesSeverityTrialsTreatment interaction effectsDepressionSevere levelsLower depressionBaseline patternsPreventionTreatmentLatent classesRelapseWho achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials
Witkiewitz K, Pearson MR, Hallgren KA, Maisto SA, Roos CR, Kirouac M, Wilson AD, Montes KS, Heather N. Who achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials. Addiction 2017, 112: 2112-2121. PMID: 28511286, PMCID: PMC5673549, DOI: 10.1111/add.13870.Peer-Reviewed Original ResearchConceptsLow-risk drinkingPatterns of drinkingHeavy drinkingAlcohol dependenceSelf-reported weekly alcohol consumptionDrinking patternsPersistent heavy drinkingRepeated-measures latent class analysisWeekly alcohol consumptionAlcohol clinical trialsBehavioral intervention studyAlcohol Treatment TrialUnited Kingdom Alcohol Treatment TrialTreatment trialsCombined PharmacotherapiesClinical trialsAverage ageAlcohol consumptionAlcohol dependence severityIntervention studiesAlcohol treatmentCollateral informantsForm 90Dependence severityLatent class analysisCoping mediates the effects of cognitive–behavioral therapy for alcohol use disorder among out‐patient clients in Project MATCH when dependence severity is high
Roos CR, Maisto SA, Witkiewitz K. Coping mediates the effects of cognitive–behavioral therapy for alcohol use disorder among out‐patient clients in Project MATCH when dependence severity is high. Addiction 2017, 112: 1547-1557. PMID: 28388836, PMCID: PMC5544539, DOI: 10.1111/add.13841.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTwelve-step facilitationCognitive behavioral therapyMotivational enhancement therapyUse disordersPositive treatment effectDependence severityDrinking outcomesTreatment effectsProject MATCHPercentage days abstinentHeavy drinking daysAlcohol Treatment TrialPrimary outcomeTreatment armsTreatment trialsSecondary data analysisDays abstinentDrinking daysAlcohol Dependence ScaleTherapyPatient samplesEnhancement therapySeverityChange QuestionnaireHow Much Is Too Much? Patterns of Drinking During Alcohol Treatment and Associations With Post-Treatment Outcomes Across Three Alcohol Clinical Trials.
Witkiewitz K, Roos CR, Pearson MR, Hallgren KA, Maisto SA, Kirouac M, Forcehimes AA, Wilson AD, Robinson CS, McCallion E, Tonigan JS, Heather N. How Much Is Too Much? Patterns of Drinking During Alcohol Treatment and Associations With Post-Treatment Outcomes Across Three Alcohol Clinical Trials. Journal Of Studies On Alcohol And Drugs 2017, 78: 59-69. PMID: 27936365, PMCID: PMC5148751, DOI: 10.15288/jsad.2017.78.59.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAlcoholismFemaleHumansMaleRandomized Controlled Trials as TopicTreatment OutcomeYoung AdultConceptsBetter long-term outcomesLong-term outcomesPersistent heavy drinkingLow-risk drinkingPatterns of drinkingHeavy drinkingClinical trialsAlcohol treatmentWorse long-term outcomesDrinking patternsWeeks of treatmentRandomized clinical trialsNon-heavy drinkingRepeated-measures latent class analysisLow-risk drinkersAlcohol use disorderPost-treatment outcomesAlcohol clinical trialsAlcohol Treatment TrialNegative long-term outcomesTreatment trialsWorse outcomesSecondary data analysisUse disordersPatients
2016
Do Alcohol Relapse Episodes During Treatment Predict Long‐Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse
Maisto SA, Roos CR, Hallgren KA, Moskal D, Wilson AD, Witkiewitz K. Do Alcohol Relapse Episodes During Treatment Predict Long‐Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse. Alcohol Clinical And Experimental Research 2016, 40: 2180-2189. PMID: 27591560, PMCID: PMC5048537, DOI: 10.1111/acer.13173.Peer-Reviewed Original ResearchConceptsWomen/menRelapse definitionAlcohol consumptionLong-term alcohol-related outcomesAlcohol use disorder treatmentEnd of treatmentLong-term outcomesUse disorder treatmentDisorder relapseSingle drinking episodeYear posttreatmentRelapseDisorder treatmentAlcohol-related consequencesAlcohol-related outcomesBest predictorRelapse episodesSecondary analysisClinical researchPsychosocial functioningAUD researchDrinking episodesOutcomesMenProject MATCHReward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone
Roos CR, Mann K, Witkiewitz K. Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone. Addiction Biology 2016, 22: 1528-1539. PMID: 27480445, PMCID: PMC5290305, DOI: 10.1111/adb.12427.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment of AUDOpioid receptor antagonistRandomized clinical trialsBetter drinking outcomesGlutamatergic systemSubtypes of individualsReceptor antagonistClinical trialsRewarding effectsUse disordersClinical decisionDrinking outcomesReward drinkersDrinkersNaltrexoneExcellent reliabilityDifferential benefitsDistinct patterns