2021
Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory
Kiluk BD, Roos CR, Aslan M, Gueorguieva R, Nich C, Babuscio TA, Carroll KM. Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory. Drug And Alcohol Dependence 2021, 228: 109070. PMID: 34600247, PMCID: PMC8595796, DOI: 10.1016/j.drugalcdep.2021.109070.Peer-Reviewed Original ResearchConceptsAddiction Severity IndexGlobal Severity IndexPsychiatric composite scoreClinical trialsCocaine useCocaine use disorderPsychiatric functioningBrief Symptom InventorySeverity IndexUse disordersASI psychiatric composite scoreSymptom InventoryEffect sizeStart of treatmentComposite scoreClinical trial participantsWeek 12Functional outcomeTreatment periodTrial participantsPsychiatric problemsDrug usePotential functional benefitsMedium effect sizeSubstance users
2020
Alexithymia and pain experience among patients using methadone-maintenance therapy
Morie KP, Potenza MN, Beitel M, Oberleitner LM, Roos CR, Yip SW, Oberleitner DE, Gaeta M, Barry DT. Alexithymia and pain experience among patients using methadone-maintenance therapy. Drug And Alcohol Dependence 2020, 218: 108387. PMID: 33168339, PMCID: PMC8103623, DOI: 10.1016/j.drugalcdep.2020.108387.Peer-Reviewed Original ResearchConceptsOpioid use disorderPain interferencePain acceptancePain experienceUse disordersMethadone maintenance therapySubset of patientsMethadone-treated patientsMethadone maintenance treatmentDrug use historyReporting painPain severityImportant intervention targetMaintenance treatmentMore painPain catastrophizingPainPatientsEffect of alexithymiaTreatment targetsDrug useIntervention targetsRole of alexithymiaRegression analysisSelf-report measuresEvaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes
Roos CR, Kiluk BD, McHugh RK, Carroll KM. Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes. Psychology Of Addictive Behaviors 2020, 34: 660-668. PMID: 32297754, PMCID: PMC7483283, DOI: 10.1037/adb0000581.Peer-Reviewed Original ResearchConceptsIllicit opioid useOpioid useDepressive symptomsUse disordersSubstance use outcomesMethadone treatmentStandard methadone treatmentTrial of galantamineUse outcomesOpioid use disorderSubstance Use Treatment OutcomesSubstance use disordersCocaine use disorderCognitive behavioral therapyLongitudinal treatment studyTreatment outcomesPredictors of endPosttreatment outcomesSymptomsTreatment studiesSignificant total effectSubstance useBaselineOutcomesDisordersIntensive Longitudinal Methods for Studying the Role of Self-Regulation Strategies in Substance Use Behavior Change
Roos CR, Kober H, Trull TJ, MacLean RR, Mun CJ. Intensive Longitudinal Methods for Studying the Role of Self-Regulation Strategies in Substance Use Behavior Change. Current Addiction Reports 2020, 7: 301-316. PMID: 33510995, PMCID: PMC7837607, DOI: 10.1007/s40429-020-00329-5.Peer-Reviewed Original ResearchSelf-regulation strategiesIntensive longitudinal methodsSubstance use disordersStrategy usePsychosocial interventionsSelf-regulation strategy useLongitudinal methodsWithin-person levelPersonalization of interventionsCollege student drinkersUse disordersEcological momentary assessmentMechanisms of changeBehavior changeDaily substance useMechanisms of substanceStudent drinkersMomentary assessmentKey next stepDrug use disordersSubstance useMobile interventionsDaily diariesPreliminary evidenceArea of researchApproach Coping and Substance Use Outcomes Following Mindfulness-Based Relapse Prevention Among Individuals with Negative Affect Symptomatology
Roos C, Bowen S, Witkiewitz K. Approach Coping and Substance Use Outcomes Following Mindfulness-Based Relapse Prevention Among Individuals with Negative Affect Symptomatology. Mindfulness 2020, 11: 2397-2410. PMID: 33510820, PMCID: PMC7837604, DOI: 10.1007/s12671-020-01456-w.Peer-Reviewed Original ResearchSubstance use disordersAffective symptomsRelapse preventionSubstance-related problemsTherapeutic effectConditional indirect effectsHeavy drinking daysApproach copingAvoidance copingSubstance use outcomesNegative affective symptomsMonth 12Conditional indirect effect modelDrinking daysUse disordersSignificant conditional indirect effectAftercare treatmentSymptomsAffective symptomatologyLatent growth curve analysisIndirect effects modelPTSD symptomsCurve analysisMethodsThe sampleSubstance useAssociations Among Sleep Disturbance, Pain Catastrophizing, and Pain Intensity for Methadone-maintained Patients With Opioid Use Disorder and Chronic Pain
Martinez CP, Edwards KA, Roos CR, Beitel M, Eller A, Barry DT. Associations Among Sleep Disturbance, Pain Catastrophizing, and Pain Intensity for Methadone-maintained Patients With Opioid Use Disorder and Chronic Pain. The Clinical Journal Of Pain 2020, 36: 641-647. PMID: 32482968, PMCID: PMC7725378, DOI: 10.1097/ajp.0000000000000848.Peer-Reviewed Original ResearchConceptsOpioid use disorderMethadone maintenance treatmentChronic painPain intensitySleep disturbancesMMT patientsUse disordersLarge cross-sectional studyGreater pain intensityCo-occurring chronic painCross-sectional studyCross-sectional associationsGreater sleep disturbanceMaintenance treatmentPain catastrophizingPain issuesKey mechanistic pathwaysPainPatientsGreater painIntensity pathwaySignificant mediation effectSelf-report measuresDisordersAssociationShort- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders
Roos CR, Carroll KM, Nich C, Frankforter T, Kiluk BD. Short- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders. Drug And Alcohol Dependence 2020, 212: 108044. PMID: 32422538, PMCID: PMC7293942, DOI: 10.1016/j.drugalcdep.2020.108044.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyPerson cognitive-behavioural therapySubstance use disordersMediation effectAlcohol use disorderComputer-delivered cognitive behavioural therapyUse disordersSame mediation effectSubstance-related copingCoping Strategies ScaleSignificant mediation effectMechanisms of changeMediational modelCoping skillsStrategies ScaleCBT4CBTStatistical mediatorCopingDrug use disordersSubstance useHeavy drinkingDisordersLong-term changesLong-term increase
2019
Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response
Witkiewitz K, Roos CR, Mann K, Kranzler HR. Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response. Alcohol Clinical And Experimental Research 2019, 43: 2395-2405. PMID: 31436886, PMCID: PMC6824945, DOI: 10.1111/acer.14183.Peer-Reviewed Original ResearchConceptsEffects of naltrexoneHeavy drinking daysAlcohol use disorderDaily naltrexoneUse disordersDrinking daysDaily drinkingPercent heavy drinking daysPrecision medicinePrecision medicine approachDaily medicationNaltrexone responseInteractive voice response technologyClinical trialsNaltrexone effectsRewarding effectsSpecific treatmentNaltrexoneSecondary analysisMedicine approachDrinkersProblem drinkersReward drinkersPlaceboDrinkingIndividual Gender and Group Gender Composition as Predictors of Differential Benefit from Mindfulness-Based Relapse Prevention for Substance Use Disorders
Roos C, Stein E, Bowen S, Witkiewitz K. Individual Gender and Group Gender Composition as Predictors of Differential Benefit from Mindfulness-Based Relapse Prevention for Substance Use Disorders. Mindfulness 2019, 10: 1560-1567. PMID: 31741686, PMCID: PMC6860023, DOI: 10.1007/s12671-019-01112-y.Peer-Reviewed Original ResearchDrug use daysSubstance use disordersHeavy drinking daysRelapse preventionUse daysMonth 12Therapy groupMore womenUse disordersDrinking daysAftercare treatmentRP groupSecondary data analysisTreatment moderatorsWomenPreventionOne-thirdDaysDisordersDifferential benefitsOutcomesGenderTreatmentAnalysis sampleGroup
2018
An Open Trial of Rolling Admission Mindfulness-Based Relapse Prevention (Rolling MBRP): Feasibility, Acceptability, Dose-Response Relations, and Mechanisms
Roos C, Kirouac M, Stein E, Wilson A, Bowen S, Witkiewitz K. An Open Trial of Rolling Admission Mindfulness-Based Relapse Prevention (Rolling MBRP): Feasibility, Acceptability, Dose-Response Relations, and Mechanisms. Mindfulness 2018, 10: 1062-1073. PMID: 31354877, PMCID: PMC6660179, DOI: 10.1007/s12671-018-1054-5.Peer-Reviewed Original ResearchMindfulness-based relapse preventionSubstance use disordersDose-response relationMental healthOpen trialRelapse preventionTotal sessionsSession mindfulness practiceShort-term residential treatmentBetter mental healthGood attendance ratesMindfulness practiceEffective treatmentUse disordersHigh satisfaction ratingsFormal mindfulness practiceAttendance ratesResidential treatmentTrialsSatisfaction ratingsHealthKey mechanismPreventionSignificant indirect effectOutcomesAbstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment
Witkiewitz K, Kirouac M, Roos CR, Wilson AD, Hallgren KA, Bravo AJ, Montes KS, Maisto SA. Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment. Psychology Of Addictive Behaviors 2018, 32: 639-646. PMID: 30160499, PMCID: PMC6136973, DOI: 10.1037/adb0000381.Peer-Reviewed Original ResearchConceptsLow-risk drinkingRisk drinkingHeavy drinkingDrinking daysAlcohol-related consequencesAlcohol usePersistent heavy drinkingWeeks of treatmentOutcomes 3 yearsDrinking outcomesHeavy drinking daysLow-risk drinkersAlcohol use disorderMeasures latent class analysisOutpatient armRisk drinkersOutcome measuresHeavy drinking episodesLower riskUse disordersHeavy drinkersFunctioning outcomesPsychosocial functioningAbstinenceDrinking episodesProfiles of recovery from alcohol use disorder at three years following treatment: can the definition of recovery be extended to include high functioning heavy drinkers?
Witkiewitz K, Wilson AD, Pearson MR, Montes KS, Kirouac M, Roos CR, Hallgren KA, Maisto SA. Profiles of recovery from alcohol use disorder at three years following treatment: can the definition of recovery be extended to include high functioning heavy drinkers? Addiction 2018, 114: 69-80. PMID: 30063267, PMCID: PMC6289769, DOI: 10.1111/add.14403.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAlcohol AbstinenceAlcoholics AnonymousAlcoholismCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansLatent Class AnalysisMaleMental HealthMental Health RecoveryMiddle AgedMotivational InterviewingPersonal SatisfactionSocial BehaviorTreatment OutcomeUnemploymentConceptsOccasional heavy drinkersAlcohol use disorderHeavy drinkersNon-heavy drinkersUse disordersPsychosocial functioningSecondary analysisMental healthInfrequent heavy drinkersTreatment-related variablesRandomized clinical trialsAlcoholics Anonymous (AA) involvementFrequent heavy drinkersPost-treatment abstinenceProfiles of recoveryClinical trialsDefinition of recoveryAlcohol-related problemsAlcohol dependence severityDrug useAlcohol useRecovery outcomesHeavy drinkingDrinkersDependence severityBroad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation.
Witkiewitz K, Roos CR, Tofighi D, Van Horn ML. Broad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation. Journal Of Studies On Alcohol And Drugs 2018, 79: 199-207. PMID: 29553346, PMCID: PMC6019776, DOI: 10.15288/jsad.2018.79.199.Peer-Reviewed Original ResearchConceptsAlcohol use disorderMedication managementBehavioral interventionsDrinking outcomesOutcomes 12 monthsCombined Behavioral InterventionCombined PharmacotherapiesUse disordersAUD treatmentCoping repertoireCOMBINE StudySecondary analysisSignificant mediatorAlcohol Dependence (COMBINE) StudyBehavioral treatmentIntervention efficacyBroad coping repertoireMultisite studyInterventionGreater likelihoodOutcomesTreatmentMediatorsAlcohol outcomesBehavior changeRace/ethnicity and racial group composition moderate the effectiveness of mindfulness-based relapse prevention for substance use disorder
Greenfield BL, Roos C, Hagler KJ, Stein E, Bowen S, Witkiewitz KA. Race/ethnicity and racial group composition moderate the effectiveness of mindfulness-based relapse prevention for substance use disorder. Addictive Behaviors 2018, 81: 96-103. PMID: 29454179, PMCID: PMC5860666, DOI: 10.1016/j.addbeh.2018.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlaska NativesAsianBlack or African AmericanCognitive Behavioral TherapyEthnicityFemaleHispanic or LatinoHumansIndians, North AmericanMaleMiddle AgedMindfulnessNative Hawaiian or Other Pacific IslanderPsychotherapy, GroupSecondary PreventionSubstance-Related DisordersTreatment OutcomeWhite People
2017
Baseline Patterns of Substance Use Disorder Severity and Depression and Anxiety Symptoms Moderate the Efficacy of Mindfulness-Based Relapse Prevention
Roos CR, Bowen S, Witkiewitz K. Baseline Patterns of Substance Use Disorder Severity and Depression and Anxiety Symptoms Moderate the Efficacy of Mindfulness-Based Relapse Prevention. Journal Of Consulting And Clinical Psychology 2017, 85: 1041-1051. PMID: 29083220, PMCID: PMC5679292, DOI: 10.1037/ccp0000249.Peer-Reviewed Original ResearchConceptsMindfulness-based relapse preventionSubstance use disordersSUD severityAnxiety symptomsRelapse preventionSUD symptomsSubstance use outcomesCognitive-behavioral relapse preventionOptimal treatmentUse disordersDepression symptomsSymptomsSymptom severityUse outcomesSeverityTrialsTreatment interaction effectsDepressionSevere levelsLower depressionBaseline patternsPreventionTreatmentLatent classesRelapseCoping mediates the effects of cognitive–behavioral therapy for alcohol use disorder among out‐patient clients in Project MATCH when dependence severity is high
Roos CR, Maisto SA, Witkiewitz K. Coping mediates the effects of cognitive–behavioral therapy for alcohol use disorder among out‐patient clients in Project MATCH when dependence severity is high. Addiction 2017, 112: 1547-1557. PMID: 28388836, PMCID: PMC5544539, DOI: 10.1111/add.13841.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTwelve-step facilitationCognitive behavioral therapyMotivational enhancement therapyUse disordersPositive treatment effectDependence severityDrinking outcomesTreatment effectsProject MATCHPercentage days abstinentHeavy drinking daysAlcohol Treatment TrialPrimary outcomeTreatment armsTreatment trialsSecondary data analysisDays abstinentDrinking daysAlcohol Dependence ScaleTherapyPatient samplesEnhancement therapySeverityChange QuestionnaireHow Much Is Too Much? Patterns of Drinking During Alcohol Treatment and Associations With Post-Treatment Outcomes Across Three Alcohol Clinical Trials.
Witkiewitz K, Roos CR, Pearson MR, Hallgren KA, Maisto SA, Kirouac M, Forcehimes AA, Wilson AD, Robinson CS, McCallion E, Tonigan JS, Heather N. How Much Is Too Much? Patterns of Drinking During Alcohol Treatment and Associations With Post-Treatment Outcomes Across Three Alcohol Clinical Trials. Journal Of Studies On Alcohol And Drugs 2017, 78: 59-69. PMID: 27936365, PMCID: PMC5148751, DOI: 10.15288/jsad.2017.78.59.Peer-Reviewed Original ResearchConceptsBetter long-term outcomesLong-term outcomesPersistent heavy drinkingLow-risk drinkingPatterns of drinkingHeavy drinkingClinical trialsAlcohol treatmentWorse long-term outcomesDrinking patternsWeeks of treatmentRandomized clinical trialsNon-heavy drinkingRepeated-measures latent class analysisLow-risk drinkersAlcohol use disorderPost-treatment outcomesAlcohol clinical trialsAlcohol Treatment TrialNegative long-term outcomesTreatment trialsWorse outcomesSecondary data analysisUse disordersPatients
2016
Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone
Roos CR, Mann K, Witkiewitz K. Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone. Addiction Biology 2016, 22: 1528-1539. PMID: 27480445, PMCID: PMC5290305, DOI: 10.1111/adb.12427.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment of AUDOpioid receptor antagonistRandomized clinical trialsBetter drinking outcomesGlutamatergic systemSubtypes of individualsReceptor antagonistClinical trialsRewarding effectsUse disordersClinical decisionDrinking outcomesReward drinkersDrinkersNaltrexoneExcellent reliabilityDifferential benefitsDistinct patterns
2015
Neuroscience and Mindfulness-Based Interventions: Translating Neural Mechanisms to Addiction Treatment
Pearson M, Roos C, Brown D, Witkiewitz K. Neuroscience and Mindfulness-Based Interventions: Translating Neural Mechanisms to Addiction Treatment. 2015, 85-96. DOI: 10.1057/9781137362650_6.ChaptersSubstance use disordersBehavioral therapyMindfulness Based Cognitive TherapyMindfulness Based Stress ReductionMindfulness-Based Relapse PreventionMindfulness-based interventionsConcept of mindfulnessDialectical behavioral therapyAdditional behavioural therapyCognitive therapyNeural mechanismsCommitment TherapyMental statesRelapse preventionMindfulnessOngoing momentSubstance useStress reductionUse disordersAddiction treatmentMood disordersPurposeful waySpiritual practicesChronic painClinical practitioners