2021
Reward drinking and naltrexone treatment response among young adult heavy drinkers
Roos CR, Bold KW, Witkiewitz K, Leeman RF, DeMartini KS, Fucito LM, Corbin WR, Mann K, Kranzler HR, O'Malley SS. Reward drinking and naltrexone treatment response among young adult heavy drinkers. Addiction 2021, 116: 2360-2371. PMID: 33620746, PMCID: PMC8328878, DOI: 10.1111/add.15453.Peer-Reviewed Original Research
2019
Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response
Witkiewitz K, Roos CR, Mann K, Kranzler HR. Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response. Alcohol Clinical And Experimental Research 2019, 43: 2395-2405. PMID: 31436886, PMCID: PMC6824945, DOI: 10.1111/acer.14183.Peer-Reviewed Original ResearchConceptsEffects of naltrexoneHeavy drinking daysAlcohol use disorderDaily naltrexoneUse disordersDrinking daysDaily drinkingPercent heavy drinking daysPrecision medicinePrecision medicine approachDaily medicationNaltrexone responseInteractive voice response technologyClinical trialsNaltrexone effectsRewarding effectsSpecific treatmentNaltrexoneSecondary analysisMedicine approachDrinkersProblem drinkersReward drinkersPlaceboDrinking
2018
Profiles of recovery from alcohol use disorder at three years following treatment: can the definition of recovery be extended to include high functioning heavy drinkers?
Witkiewitz K, Wilson AD, Pearson MR, Montes KS, Kirouac M, Roos CR, Hallgren KA, Maisto SA. Profiles of recovery from alcohol use disorder at three years following treatment: can the definition of recovery be extended to include high functioning heavy drinkers? Addiction 2018, 114: 69-80. PMID: 30063267, PMCID: PMC6289769, DOI: 10.1111/add.14403.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAlcohol AbstinenceAlcoholics AnonymousAlcoholismCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansLatent Class AnalysisMaleMental HealthMental Health RecoveryMiddle AgedMotivational InterviewingPersonal SatisfactionSocial BehaviorTreatment OutcomeUnemploymentConceptsOccasional heavy drinkersAlcohol use disorderHeavy drinkersNon-heavy drinkersUse disordersPsychosocial functioningSecondary analysisMental healthInfrequent heavy drinkersTreatment-related variablesRandomized clinical trialsAlcoholics Anonymous (AA) involvementFrequent heavy drinkersPost-treatment abstinenceProfiles of recoveryClinical trialsDefinition of recoveryAlcohol-related problemsAlcohol dependence severityDrug useAlcohol useRecovery outcomesHeavy drinkingDrinkersDependence severityBroad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation.
Witkiewitz K, Roos CR, Tofighi D, Van Horn ML. Broad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation. Journal Of Studies On Alcohol And Drugs 2018, 79: 199-207. PMID: 29553346, PMCID: PMC6019776, DOI: 10.15288/jsad.2018.79.199.Peer-Reviewed Original ResearchConceptsAlcohol use disorderMedication managementBehavioral interventionsDrinking outcomesOutcomes 12 monthsCombined Behavioral InterventionCombined PharmacotherapiesUse disordersAUD treatmentCoping repertoireCOMBINE StudySecondary analysisSignificant mediatorAlcohol Dependence (COMBINE) StudyBehavioral treatmentIntervention efficacyBroad coping repertoireMultisite studyInterventionGreater likelihoodOutcomesTreatmentMediatorsAlcohol outcomesBehavior change
2016
Do Alcohol Relapse Episodes During Treatment Predict Long‐Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse
Maisto SA, Roos CR, Hallgren KA, Moskal D, Wilson AD, Witkiewitz K. Do Alcohol Relapse Episodes During Treatment Predict Long‐Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse. Alcohol Clinical And Experimental Research 2016, 40: 2180-2189. PMID: 27591560, PMCID: PMC5048537, DOI: 10.1111/acer.13173.Peer-Reviewed Original ResearchConceptsWomen/menRelapse definitionAlcohol consumptionLong-term alcohol-related outcomesAlcohol use disorder treatmentEnd of treatmentLong-term outcomesUse disorder treatmentDisorder relapseSingle drinking episodeYear posttreatmentRelapseDisorder treatmentAlcohol-related consequencesAlcohol-related outcomesBest predictorRelapse episodesSecondary analysisClinical researchPsychosocial functioningAUD researchDrinking episodesOutcomesMenProject MATCHAdding Tools to the Toolbox: The Role of Coping Repertoire in Alcohol Treatment
Roos CR, Witkiewitz K. Adding Tools to the Toolbox: The Role of Coping Repertoire in Alcohol Treatment. Journal Of Consulting And Clinical Psychology 2016, 84: 599-611. PMID: 27054825, PMCID: PMC4919128, DOI: 10.1037/ccp0000102.Peer-Reviewed Original ResearchConceptsTreatment outcomesAlcohol treatment outcomesAUD treatmentAlcohol use disorder populationBetter treatment outcomesAUD populationsDistinct patternsCOMBINE StudySecondary analysisBehavioral interventionsDisorder populationBroad coping repertoireChange QuestionnaireGreater likelihoodProject MATCHOne's repertoireCoping skillsOutcomesImportant targetTreatmentCoping repertoireExpected classificationFurther researchDifferent coping skillsPopulation