Natural cubic splines for the analysis of Alzheimer’s trials
Donohue M, Langford O, Insel P, van Dyck C, Petersen R, Craft S, Raman R, Sims J, Sperling R, Aisen P. Natural cubic splines for the analysis of Alzheimer’s trials. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.070862.Peer-Reviewed Original ResearchVersion effectsType I error controlNatural cubic splinesDegrees of freedomPreclinical AlzheimerTreatment effect estimatesType I errorMild dementiaProportional treatment effectLongitudinal data analysisSimulation studyModel selection techniquesMild Alzheimer's dementiaEffect assumptionSpline modelMMRMCubic splinesSplinesA4 studyTrial of donepezilOff-scheduleADAS-CogAlzheimer's dementiaEffect estimatesTreat principle