2021
Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace S, Rossetti MG, Allen N, Batalla A, Bellani M, Brambilla P, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Labuschagne I, Momenan R, Martin-Santos R, Rendell P, Solowij N, Sinha R, Li CR, Schmaal L, Sjoerds Z, Suo C, Terrett G, van Holst RJ, Veltman DJ, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Lorenzetti V. Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry 2021, 11: 156. PMID: 33664226, PMCID: PMC7933136, DOI: 10.1038/s41398-021-01204-1.Peer-Reviewed Original ResearchConceptsENIGMA Addiction Working GroupAlcohol dependenceAmygdala subregionsAlcohol-dependent malesUnderlying neurobiological mechanismsSex differencesSubfield volumesTotal amygdalaAlcohol doseBasolateral nucleusAnimal modelsMale controlsWorking GroupAmygdalar subregionsMental healthNeurobiological mechanismsComparison groupCognitive problemsHippocampusMalesFemalesDistinct mechanismsLittle evidenceGroupAmygdala
2019
Threat bias and resting state functional connectivity of the amygdala and bed nucleus stria terminalis
Jenks SK, Zhang S, Li CR, Hu S. Threat bias and resting state functional connectivity of the amygdala and bed nucleus stria terminalis. Journal Of Psychiatric Research 2019, 122: 54-63. PMID: 31927266, PMCID: PMC7010552, DOI: 10.1016/j.jpsychires.2019.12.017.Peer-Reviewed Original ResearchConceptsHealthy controlsState functional connectivityStria terminalisFunctional connectivityAnxiety disordersBed nucleus stria terminalisNucleus stria terminalisAnxiety-related disordersBed nucleusClinical heterogeneityComorbid anxietyWhole brainAmygdalaIntrinsic connectivityRSFCNathan Kline Institute-Rockland SampleAnticipatory anxietyBNSTGroup differencesNeural markersDisordersPatientsTerminalisImaging resultsCurrent findingsConcurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation
Yang M, Tsai SJ, Li CR. Concurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation. Brain Structure And Function 2019, 225: 345-363. PMID: 31863185, PMCID: PMC6960357, DOI: 10.1007/s00429-019-02007-3.Peer-Reviewed Original ResearchConceptsActivation likelihood estimationPassive exposureAmygdala activityNegative emotionsRight amygdala activityEmotion processingPosterior cingulate cortexWhole-brain analysisPrefrontal cortical responsesCortical responsesLeft amygdalaCingulate cortexVentromedial prefrontal cortexBilateral amygdalaVentral striatumPrefrontal cortexConvergent activityAmygdalaVentral precuneusEffects of valenceCortexExposureVmPFCPositive emotionsVmPFC responses
2018
Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers
Hu S, Ide JS, Chao HH, Zhornitsky S, Fischer KA, Wang W, Zhang S, Li CR. Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers. Drug And Alcohol Dependence 2018, 185: 173-180. PMID: 29454928, PMCID: PMC5889735, DOI: 10.1016/j.drugalcdep.2017.11.026.Peer-Reviewed Original ResearchConceptsState functional connectivityDorsal anterior cingulate cortexAlcohol misuseAlcohol drinkersFunctional connectivityInvolvement scoreProblem drinkingSubstance useWhole-brain rsFCComorbid substance useAmygdala-prefrontal cortical circuitAnterior cingulate cortexStatistical parametric mappingPotential sex differencesPrefrontal cortical structuresAmygdala connectivityCortical functionCortical circuitsCingulate cortexAmygdalaCortical structuresParametric mappingSex differencesDrinkingDrinkers
2009
Altered Impulse Control in Alcohol Dependence: Neural Measures of Stop Signal Performance
Li C, Luo X, Yan P, Bergquist K, Sinha R. Altered Impulse Control in Alcohol Dependence: Neural Measures of Stop Signal Performance. Alcohol Clinical And Experimental Research 2009, 33: 740-750. PMID: 19170662, PMCID: PMC2697053, DOI: 10.1111/j.1530-0277.2008.00891.x.Peer-Reviewed Original ResearchConceptsHealthy control subjectsFunctional magnetic resonance imagingAlcohol dependencePost-error behavioral adjustmentDorsolateral prefrontal cortexAlcohol urgesTrial reaction timePost-error slowingPrefrontal cortexLeft dorsolateral prefrontal cortexRight dorsolateral prefrontal cortexMagnetic resonance imagingImpulse controlStatistical parametric mappingStop errorAbstinent patientsControl subjectsNovel pharmacotherapiesSignal reaction timeTreatment outcomesFrontal cortexHC subjectsResonance imagingBehavioral adjustmentSubcortical structuresDecreased Amygdala Activation during Risk Taking in Non-Dependent Habitual Alcohol Users: A Preliminary fMRI Study of the Stop Signal Task
Yan P, Li CS. Decreased Amygdala Activation during Risk Taking in Non-Dependent Habitual Alcohol Users: A Preliminary fMRI Study of the Stop Signal Task. The American Journal Of Drug And Alcohol Abuse 2009, 35: 284-289. PMID: 19579091, PMCID: PMC4511157, DOI: 10.1080/00952990902968569.Peer-Reviewed Original ResearchConceptsStop-signal taskAlcohol drinkersAmygdala activationAlcohol dependenceNon-dependent social drinkersInhibitory controlAlcohol useHabitual alcohol useHeavy alcohol drinkersSignal taskAlcohol-dependent patientsPreliminary fMRI studyAltered brain activationFunctional magnetic resonance imagingMagnetic resonance imagingDependent patientsNeural processesHabitual drinkingHealthy controlsCurrent preliminary studyAlcohol usersResonance imagingStop trialsLight drinkersKey neural processes