2023
Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals
Dong X, Zhornitsky S, Wang W, Le T, Chen Y, Chaudhary S, Li C, Zhang S. Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. The International Journal Of Neuropsychopharmacology 2023, 26: 627-638. PMID: 37579016, PMCID: PMC10519818, DOI: 10.1093/ijnp/pyac019.Peer-Reviewed Original ResearchMeSH KeywordsCocaineCocaine-Related DisordersHumansImpulsive BehaviorMagnetic Resonance ImagingPrefrontal CortexVentral StriatumConceptsResting-state functional connectivityInferior frontal cortexCocaine-dependent individualsHealthy controlsVentral striatumCocaine useDorsal striatumAbstinent cocaine-dependent individualsCocaine misuseFunctional connectivityYears of drinkingLeft orbitofrontal cortexBIS-11 scoresRecent cocaine useLeft inferior frontal cortexDopaminergic deficitCortex connectivityFrontal cortexSeparate cohortHuman studiesSeverity of useAnimal studiesSecond cohortOrbitofrontal cortexBarratt Impulsivity ScaleSex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss
Li G, Li Y, Zhang Z, Chen Y, Li B, Hao D, Yang L, Yang Y, Li X, Li C. Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss. Journal Of Psychiatric Research 2023, 162: 11-20. PMID: 37062201, PMCID: PMC10225357, DOI: 10.1016/j.jpsychires.2023.04.013.Peer-Reviewed Original Research
2021
Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task
Zhornitsky S, Dhingra I, Le TM, Wang W, Li CR, Zhang S. Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task. The International Journal Of Neuropsychopharmacology 2021, 24: 634-644. PMID: 33822080, PMCID: PMC8378081, DOI: 10.1093/ijnp/pyab016.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsCocaine Craving QuestionnaireCCQ scoresRecent cocaine useHealthy controlsMonetary incentive delay taskReward-related responsesCocaine useVentral striatumIncentive delay taskMotor cortexReward responsesPrecentral gyrusCocaine addictionPrimary motor cortexSupplementary motor areaDelay taskIntense drug cravingFunctional magnetic resonance imagingMagnetic resonance imagingDrug-seeking behaviorHigher activationReward-related activityMotor areaWhole brain
2020
The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use
Le TM, Wang W, Zhornitsky S, Dhingra I, Chen Y, Zhang S, Li CR. The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use. The International Journal Of Neuropsychopharmacology 2020, 24: 333-343. PMID: 33211853, PMCID: PMC8059487, DOI: 10.1093/ijnp/pyaa086.Peer-Reviewed Original ResearchConceptsSocial supportVentral striatumVS connectivityAlcohol misuseSocial isolationWhole-brain multiple regressionProblem drinkingProblem drinkersAlcohol useResting-state functional magnetic resonanceFunctional magnetic resonanceMiddle frontal gyrusPotential protective factorsProblem alcohol usePrefrontal cortical modulationCognitive controlIndividual differencesNeural processesNeural substratesFrontal gyrusPrefrontal connectivityElevated stress responseFunctional connectivityPath analysisNeural connectivity
2019
Striatal functional connectivity in chronic ketamine users: a pilot study
Hung CC, Zhang S, Chen CM, Duann JR, Lin CP, Lee TS, Li CR. Striatal functional connectivity in chronic ketamine users: a pilot study. The American Journal Of Drug And Alcohol Abuse 2019, 46: 31-43. PMID: 31264888, PMCID: PMC8627683, DOI: 10.1080/00952990.2019.1624764.Peer-Reviewed Original ResearchConceptsDuration of useChronic ketamine usersKetamine usersKetamine useKetamine misuseOrbitofrontal cortexFunctional connectivityStriatal functional connectivityState functional connectivityLeft orbitofrontal cortexBIS-11 scoresDorsal anterior cingulate cortexVoxel-wise connectivityAnterior cingulate cortexMagnetic resonance imagingOFC connectivityHealthy controlsBilateral cerebellumStriatal connectivityCingulate cortexResonance imagingControl dysfunctionVentral striatumZ-scorePilot study
2018
Ventral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity
Zhang S, Li CR. Ventral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity. Translational Psychiatry 2018, 8: 119. PMID: 29915214, PMCID: PMC6006289, DOI: 10.1038/s41398-018-0164-0.Peer-Reviewed Original ResearchConceptsState functional connectivityCocaine dependenceVentral striatumFunctional connectivityVentral striatal dysfunctionExtent of depressionCircuit deficitsDopaminergic deficitFunctional dysconnectivityStriatal dysfunctionRSFC differencesVmPFC connectivitySubregional changesRsFC changesParahippocampal gyrusCocaine cravingCortical connectivityHealthy populationVentromedial prefrontal cortexVisual cortexMental illnessCocaine useRSFCPrefrontal cortexFunctional subregions
2017
Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study
Zhang S, Hu S, Chao HH, Li CR. Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study. Brain Structure And Function 2017, 222: 2573-2583. PMID: 28110447, PMCID: PMC5540792, DOI: 10.1007/s00429-016-1358-y.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPosterior cingulate cortexIntraparietal sulcusVentral striatumSupramarginal gyrusVS connectivityFunctional connectivityDorsomedial prefrontal cortexAutomated Anatomic Labeling (AAL) atlasFunctional hemispheric asymmetriesCerebral functional organizationGender differencesHuman Connectome ProjectRight lateralizationSelf-ControlHemispheric lateralizationPrefrontal cortexSaliency responsesBehavioral contingenciesFunctional lateralizationMotivated behaviorHemispheric asymmetryCingulate cortexConnectome ProjectLaterality index
2016
Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum
Zhang J, Ma S, Li C, Liu L, Xia C, Lan J, Wang L, Liu B, Yao Y, Fang X. Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum. Addiction Biology 2016, 23: 337-346. PMID: 27894158, PMCID: PMC5446940, DOI: 10.1111/adb.12474.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPsychobehavioral interventionsIGD subjectsFunctional connectivityHealthy controlsInternet gaming disorderGreater resting-state functional connectivityFrontal gyrusEffects of CBICross-sectional studyBehavioral intervention studyDirect current stimulationInferior parietal lobuleMiddle frontal gyrusGaming disorderSeverity of IGDInferior frontal gyrusSimilar time intervalsEffective treatmentIntervention studiesNon-invasive techniquePotential biomarkersVentral striatumParietal lobuleCurrent stimulation