2022
Cortical profiles of numerous psychiatric disorders and normal development share a common pattern
Cao Z, Cupertino R, Ottino-Gonzalez J, Murphy A, Pancholi D, Juliano A, Chaarani B, Albaugh M, Yuan D, Schwab N, Stafford J, Goudriaan A, Hutchison K, Li C, Luijten M, Groefsema M, Momenan R, Schmaal L, Sinha R, van Holst R, Veltman D, Wiers R, Porjesz B, Lett T, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Robinson L, Smolka M, Walter H, Winterer J, Schumann G, Whelan R, Bhatt R, Zhu A, Conrod P, Jahanshad N, Thompson P, Mackey S, Garavan H. Cortical profiles of numerous psychiatric disorders and normal development share a common pattern. Molecular Psychiatry 2022, 28: 698-709. PMID: 36380235, DOI: 10.1038/s41380-022-01855-6.Peer-Reviewed Original ResearchConceptsCortical thicknessPsychiatric disordersNumerous psychiatric disordersNeurological disordersDesikan-Killiany atlasLower cortical thicknessNormative maturationAllen Human Brain AtlasHealthy adult participantsCortical maturationExpression of PC1Cortical changesEmergence of psychopathologyBrain maturationPsychiatric diseasesMultiple gene ontology categoriesHuman Brain AtlasCortical profilesPubertal transitionCT differencesDisordersLate childhoodABCD studyAdult participantsNeurobiological basisSex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariatesGray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability
Chen Y, Ide JS, Li CS, Chaudhary S, Le TM, Wang W, Zhornitsky S, Zhang S, Li C. Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability. Human Brain Mapping 2022, 43: 2634-2652. PMID: 35212098, PMCID: PMC9057091, DOI: 10.1002/hbm.25810.Peer-Reviewed Original ResearchConceptsGray matter volumeImpulsivity traitsPositive urgencyVolumetric correlatesSensation seekingHigher positive urgencyMid-cingulate cortexSex differencesVoxel-based morphometry analysisSmaller gray matter volumeImpulsivity dimensionsSubsample of twinsDistinct correlatesCingulate cortexPrecentral gyrusSubcortical gray matter volumesMatter volumeTotal intracranial volumeSeekingImpulsivityMorphometry analysisPrevious researchInsulaCorrelatesGirlsThe thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson P, Stein D, van den Heuvel O, Vriend C. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder. Translational Psychiatry 2022, 12: 70. PMID: 35190533, PMCID: PMC8861046, DOI: 10.1038/s41398-022-01823-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMagnetic resonance imagingThalamic volumeOCD patientsThalamic subregionsT1-weighted brain magnetic resonance imagingBrain magnetic resonance imagingClinical-level symptomsLarger thalamic volumesPediatric OCD patientsAdult OCD patientsSeparate multiple linear regression modelsVolumetric group differencesThalamus sizeMedicated patientsAdolescent patientsAnterior thalamusHealthy controlsSubregional volumesGeneral populationMedication statusMultiple comparison correctionPatientsResonance imagingIntracranial volume
2020
Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder
Wang L, Yin Y, Bian Q, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong LE, Tan Y. Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder. Journal Of Affective Disorders 2020, 278: 672-677. PMID: 33125910, DOI: 10.1016/j.jad.2020.10.029.Peer-Reviewed Original ResearchConceptsChildhood Trauma QuestionnaireDiagnosis of BDBipolar disorderBD-IIChildhood traumaTotal scoreImmature defense mechanismsImmature defense stylesImportant risk factorDefense Style QuestionnairePhysical neglectPsychosocial intervention strategiesDefense mechanismsEmotional abuseSevere childhood traumaBD patientsDefense stylesRisk factorsHealthy controlsHealthy volunteersChildhood traumatic experiencesPatientsDSM-IVTraumaTrauma QuestionnaireGray matter volumetric correlates of behavioral activation and inhibition system traits in children: An exploratory voxel-based morphometry study of the ABCD project data
Ide JS, Li HT, Chen Y, Le TM, Li CSP, Zhornitsky S, Li CR. Gray matter volumetric correlates of behavioral activation and inhibition system traits in children: An exploratory voxel-based morphometry study of the ABCD project data. NeuroImage 2020, 220: 117085. PMID: 32592852, PMCID: PMC7572877, DOI: 10.1016/j.neuroimage.2020.117085.Peer-Reviewed Original ResearchConceptsBehavioral activation systemBehavioral inhibition systemGray matter volumeHigher BAS scoresVentral striatumBAS scoresInhibition systemBIS scoresInferior frontal cortexFundamental behavioral traitsTwins/siblingsRight anterior insulaHigher BIS scoresNeural correlatesDevelopmental neuroscienceAnterior insulaVolumetric correlatesVoxel-based morphometry studyInternalizing psychopathologyCerebral basisVoxel-based morphometryBehavioral activationVentral caudateAvoidance traitsMatter volumeKTN1 variants and risk for attention deficit hyperactivity disorder
Luo X, Guo X, Tan Y, Zhang Y, Garcia‐Milian R, Wang Z, Shi J, Yu T, Ji J, Wang X, Xu J, Zhang H, Zuo L, Lu L, Wang K, Li C. KTN1 variants and risk for attention deficit hyperactivity disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2020, 183: 234-244. PMID: 32190980, PMCID: PMC7210069, DOI: 10.1002/ajmg.b.32782.Peer-Reviewed Original ResearchInterpersonal Risk Factors for Suicide in Cocaine Dependence: Association with Self‐Esteem, Personality Traits, and Childhood Abuse
Zhornitsky S, Le TM, Dhingra I, Adkinson BD, Potvin S, Li C. Interpersonal Risk Factors for Suicide in Cocaine Dependence: Association with Self‐Esteem, Personality Traits, and Childhood Abuse. Suicide And Life-Threatening Behavior 2020, 50: 867-883. PMID: 32030810, PMCID: PMC7518050, DOI: 10.1111/sltb.12621.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsHarm avoidanceChildhood abusePersonality traitsSexual abuseCocaine dependenceGreater emotional abuseLow harm avoidanceInterpersonal risk factorsElevated harm avoidancePredictors of PbLack of belongingnessInterpersonal theoryNovelty seekingEmotional abuseSelf-EsteemHealthy controlsGroup differencesPhysical abuseSubstance useAbuseSuicidal behaviorAvoidanceDepressionSex analysis
2012
Rare ADH Variant Constellations are Specific for Alcohol Dependence
Zuo L, Zhang H, Malison RT, Li CS, Zhang XY, Wang F, Lu L, Lu L, Wang X, Krystal JH, Zhang F, Deng HW, Luo X. Rare ADH Variant Constellations are Specific for Alcohol Dependence. Alcohol And Alcoholism 2012, 48: 9-14. PMID: 23019235, PMCID: PMC3523382, DOI: 10.1093/alcalc/ags104.Peer-Reviewed Original Research
2004
A Psychophysical Measure of Attention Deficit in Children With Attention-Deficit/Hyperactivity Disorder
Li CS, Lin WH, Chang HL, Hung YW. A Psychophysical Measure of Attention Deficit in Children With Attention-Deficit/Hyperactivity Disorder. Journal Of Psychopathology And Clinical Science 2004, 113: 228-236. PMID: 15122943, DOI: 10.1037/0021-843x.113.2.228.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderADHD childrenAttention deficitsHyperactivity disorderRapid serial visual presentation taskVisual presentation taskSignal detection theoryClose temporal proximitySecond control experimentAttentional blinkPresentation taskAttention impairmentDetection theoryPsychophysical measuresTemporal proximityAttention gateTemporal mechanismsBlinkChildrenDeficitsImpairmentDistractorsDisordersTaskParticipants
2003
Inhibition of return in children with attention deficit hyperactivity disorder
Li CS, Chang HL, Lin SC. Inhibition of return in children with attention deficit hyperactivity disorder. Experimental Brain Research 2003, 149: 125-130. PMID: 12592510, DOI: 10.1007/s00221-002-1362-8.Peer-Reviewed Original ResearchConceptsInhibition of returnADHD childrenMagnitude of IORCue-target onset asynchroniesAttention deficit hyperactivity disorderDeficit hyperactivity disorderEye movement controlAttentional shiftsNeutral cuesOnset asynchronyOculomotor planningHyperactivity disorderBehavioral tasksADHD subjectsLatency profilesPositive componentADHDEye movementsSpatial locationControl subjectsPeripheral targetsMovement controlLatency differenceGender-matched control subjectsCurrent study