Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis
Chao HH, Uchio E, Zhang S, Hu S, Bednarski SR, Luo X, Rose M, Concato J, Li CS. Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis. BMC Cancer 2012, 12: 371. PMID: 22925152, PMCID: PMC3502584, DOI: 10.1186/1471-2407-12-371.Peer-Reviewed Original ResearchMeSH KeywordsAgedAndrogen AntagonistsAnilidesAntineoplastic Agents, HormonalBrainCognitionCohort StudiesGoserelinHumansMagnetic Resonance ImagingMaleMemoryMiddle AgedNeuropsychological TestsNitrilesProspective StudiesProstatic NeoplasmsPsychomotor PerformanceQuality of LifeSurveys and QuestionnairesTosyl CompoundsTreatment OutcomeConceptsAndrogen deprivation therapyFunctional magnetic resonance imagingProspective observational cohort analysisObservational cohort analysisN-back taskStop-signal taskCognitive controlProstate cancerBrain activationCohort analysisLow-risk prostate cancerNon-metastatic prostate cancerVeterans Affairs Medical CenterLong-term clinical implicationsBrain connectivityProstate cancer patientsPrefrontal cortical activationQuality of lifeFunctional brain connectivityMagnetic resonance imagingMedial prefrontal cortexParticular clinical concernDeprivation therapyADT useAndrogen deprivation