2022
Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia
Li N, Li Y, Huang J, Zhang P, Tong J, Chen S, Cui Y, Tan S, Wang Z, Yang F, Hong E, Li CR, Tian L, Tan Y. Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia. Neuroscience Letters 2022, 777: 136581. PMID: 35337952, DOI: 10.1016/j.neulet.2022.136581.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Abnormal Involuntary Movement ScaleTardive dyskinesiaChronic schizophrenia patientsSchizophrenia patientsMATRICS Consensus Cognitive BatteryReceptor 4TD patientsHigher toll-like receptor 4Cognitive deficitsSeverity of TDNegative Syndrome ScaleInnate immune systemNTD patientsTLR4 levelsHealthy controlsAIMS scoresMovement ScalePatientsConsensus Cognitive BatteryLPS stimulationTLR4 signalsPathway disturbancesLipopolysaccharide (LPS) stimulationSyndrome Scale
2018
Resting-state Brain Activity Changes Associated with Tardive Dyskinesia in Patients with Schizophrenia: Fractional Amplitude of Low-frequency Fluctuation Decreased in the Occipital Lobe
Zhang P, Li Y, Fan F, Li CR, Luo X, Yang F, Yao Y, Tan Y. Resting-state Brain Activity Changes Associated with Tardive Dyskinesia in Patients with Schizophrenia: Fractional Amplitude of Low-frequency Fluctuation Decreased in the Occipital Lobe. Neuroscience 2018, 385: 237-245. PMID: 29909076, DOI: 10.1016/j.neuroscience.2018.06.014.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleMiddle occipital gyrusRight calcarine sulcusTardive dyskinesiaBrain activity changesClinical parametersLeft middle occipital gyrusSchizophrenic patientsCalcarine sulcusOccipital lobeSeverity of TDAIMS total scoreDecreased brain activityFractional amplitudeResting-state functional magnetic resonance imaging (fMRI) dataResting-state brain activityLow-frequency fluctuationsNegative Syndrome ScaleBrain activityActivity changesConstructional scoresTD groupTD patientsHealthy controlsMagnetic resonance imaging data