2016
Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait
Kann S, Zhang S, Manza P, Leung HC, Li C. Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait. Brain Connectivity 2016, 6: 724-734. PMID: 27604154, PMCID: PMC5105339, DOI: 10.1089/brain.2016.0443.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior insulaFunctional connectivityLaterality indexDorsomedial prefrontal cortexInferior frontal cortexAutomated Anatomic Labeling (AAL) atlasSuperior parietal lobuleCerebral functional organizationSuperior frontal gyrusPosterior orbital gyrusAttentional orientationAffective processingInsula activationRight lateralizationAffective controlLeft lateralizationSalient stimuliPhysiological arousalTridimensional Personality QuestionnaireFrontal gyrusHemispheric lateralizationSupramarginal gyrusLateralized connectivityParietal lobuleDissociable Fronto-Operculum-Insula Control Signals for Anticipation and Detection of Inhibitory Sensory Cue.
Cai W, Chen T, Ide JS, Li CR, Menon V. Dissociable Fronto-Operculum-Insula Control Signals for Anticipation and Detection of Inhibitory Sensory Cue. Cerebral Cortex 2016, 27: 4073-4082. PMID: 27473319, PMCID: PMC6059112, DOI: 10.1093/cercor/bhw219.Peer-Reviewed Original ResearchConceptsInhibitory cuesInhibitory controlIndependent functional magnetic resonanceSensory cortexCausal influenceInferior frontal cortexMultiple sensory modalitiesFunctional magnetic resonanceAnterior insular cortexDynamic causal interactionsStrong causal influencesCue anticipationPrimary sensory cortexPrepotent responsesSalient stimuliSalient cuesSensory modalitiesTrial changesSensory cuesAdaptive behaviorCuesRight frontoRIFCExternal cuesHigher anticipation
2015
Barratt Impulsivity and Neural Regulation of Physiological Arousal
Zhang S, Hu S, Hu J, Wu PL, Chao HH, Li CS. Barratt Impulsivity and Neural Regulation of Physiological Arousal. PLOS ONE 2015, 10: e0129139. PMID: 26079873, PMCID: PMC4469608, DOI: 10.1371/journal.pone.0129139.Peer-Reviewed Original ResearchConceptsSkin conductance responsesImpulsive individualsNeural basisPhysiological arousalArousal regulationHigh impulsivityBarratt impulsivitySkin conductanceGreater skin conductance responsesFunctional magnetic resonance imagingVentromedial prefrontal cortexStop-signal taskTheory of personalityBarratt Impulsivity ScalePoor impulse controlVmPFC activitySalient stimuliExternal stimulationImpulsive womenNeural processesNeural substratesSignal taskConductance responsesImpulsivity ScaleImpulsivity
2014
The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults
Farr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults. Experimental And Clinical Psychopharmacology 2014, 22: 154-165. PMID: 24188171, PMCID: PMC4105943, DOI: 10.1037/a0034465.Peer-Reviewed Original ResearchConceptsStop-signal taskSalient stimuliSaliency processingFunctional MRIAttention deficit hyperactivity disorderRight inferior parietal cortexHigh motivational valueDeficit hyperactivity disorderEffects of methylphenidateInferior parietal cortexHealthy adultsNeural basisCognitive functioningMotivational valueAttention disordersHyperactivity disorderBilateral caudate headCatecholaminergic signalingMethylphenidate groupParietal cortexCerebral activationHigher activationCatecholaminergic treatmentPrimary motor cortexCerebral activity
2007
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li CS, Sinha R. Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction. Neuroscience & Biobehavioral Reviews 2007, 32: 581-597. PMID: 18164058, PMCID: PMC2263143, DOI: 10.1016/j.neubiorev.2007.10.003.Peer-Reviewed Original ResearchConceptsInhibitory controlPrefrontal activityDrug seekingHabitual drug seekingCognitive inhibitory controlCompulsive drug seekingVentromedial prefrontal regionsFrontal-limbic dysfunctionStress-related cravingAnterior cingulate cortexStress regulationPsychological processesNeural underpinningsSalient stimuliStress processingPrefrontal regionsComponent processesStriatal responsesDrug use behaviorsCingulate cortexNeural systemsPsychostimulant dependenceUse behaviorsNeural pathwaysAddiction