2023
The effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition
Li G, Zhang Z, Zhang Y, Tang X, Li C. The effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition. Psychiatry Research Neuroimaging 2023, 336: 111734. PMID: 37871409, DOI: 10.1016/j.pscychresns.2023.111734.Peer-Reviewed Original ResearchConceptsDays of abstinenceStop-signal reaction timeHealthy controlsCocaine dependenceSuperior temporal gyrusCocaine use severityStop-signal taskCocaine useResponse inhibitionUse severityBilateral superior temporal gyrusFunctional magnetic resonanceWhole-brain regressionNeural processesPoor response inhibitionInhibition dysfunctionCerebral markersTemporal gyrusSTG activityAbstinenceSuccess trialsSeverityNeural mechanismsInhibitionBehavioral performanceThe effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problems
2021
Alcohol use severity and the neural correlates of the effects of sleep disturbance on sustained visual attention
Li G, Chen Y, Tang X, Li CR. Alcohol use severity and the neural correlates of the effects of sleep disturbance on sustained visual attention. Journal Of Psychiatric Research 2021, 142: 302-311. PMID: 34416549, PMCID: PMC8429210, DOI: 10.1016/j.jpsychires.2021.08.018.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexNeural correlatesAlcohol useSleep disturbancesReaction timeSustained visual attentionAlcohol misuseWhole-brain regressionGreater sleep disturbanceHuman Connectome ProjectSevere alcohol useVisual attentionSustained attentionNeural processesCognitive performanceLow accuracy rateLonger reaction timesPerformance accuracyConnectome ProjectNeural correlates of individual variation in two-back working memory and the relationship with fluid intelligence
Li G, Chen Y, Le TM, Wang W, Tang X, Li CR. Neural correlates of individual variation in two-back working memory and the relationship with fluid intelligence. Scientific Reports 2021, 11: 9980. PMID: 33976306, PMCID: PMC8113462, DOI: 10.1038/s41598-021-89433-8.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexN-back performanceRight anterior insulaStandard Progressive Matrices testFluid intelligenceNeural correlatesReaction timePre-supplementary motor areaRaven's Standard Progressive Matrices testN-back taskIndividual variationHuman Connectome Project datasetProgressive Matrices TestProlonged response timeBilateral frontoparietal cortexAnterior cingulate cortexTwo-backNeural basisDorsal precuneusRSPM performanceNeural processesNeural substratesAnterior insulaCerebral correlatesCorrect itemsPerceived friendship and binge drinking in young adults: A study of the Human Connectome Project data
Li G, Chen Y, Le TM, Zhornitsky S, Wang W, Dhingra I, Zhang S, Tang X, Li CR. Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data. Drug And Alcohol Dependence 2021, 224: 108731. PMID: 33915512, PMCID: PMC8641247, DOI: 10.1016/j.drugalcdep.2021.108731.Peer-Reviewed Original ResearchConceptsNon-binge drinkersRight posterior insulaPeer influenceYoung adult binge drinkingSocial cognition tasksSocial cognitive processingAlcohol useBinge drinkingWhole-brain regressionAdult binge drinkingYoung adultsMedial orbitofrontal cortexHuman Connectome ProjectRPI activityAlcohol use severityHuman Connectome Project dataSocial cognitionCognition tasksCognitive processingNeural correlatesNeural processesPotential sex differencesOrbitofrontal cortexPosterior insulaConnectome Project
2020
The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use
Le TM, Wang W, Zhornitsky S, Dhingra I, Chen Y, Zhang S, Li CR. The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use. The International Journal Of Neuropsychopharmacology 2020, 24: 333-343. PMID: 33211853, PMCID: PMC8059487, DOI: 10.1093/ijnp/pyaa086.Peer-Reviewed Original ResearchConceptsSocial supportVentral striatumVS connectivityAlcohol misuseSocial isolationWhole-brain multiple regressionProblem drinkingProblem drinkersAlcohol useResting-state functional magnetic resonanceFunctional magnetic resonanceMiddle frontal gyrusPotential protective factorsProblem alcohol usePrefrontal cortical modulationCognitive controlIndividual differencesNeural processesNeural substratesFrontal gyrusPrefrontal connectivityElevated stress responseFunctional connectivityPath analysisNeural connectivitySex Differences in Neural Responses to the Perception of Social Interactions
Li G, Chen Y, Wang W, Dhingra I, Zhornitsky S, Tang X, Li CR. Sex Differences in Neural Responses to the Perception of Social Interactions. Frontiers In Human Neuroscience 2020, 14: 565132. PMID: 33061901, PMCID: PMC7518190, DOI: 10.3389/fnhum.2020.565132.Peer-Reviewed Original ResearchMiddle frontal gyrusBilateral anterior insulaAnterior insulaSocial interactionHigher activationNeural responsesRight inferior frontal cortexSex differencesPre-supplementary motor areaSocial cognition tasksParacentral lobuleRight superior temporal gyrusWhole-brain regressionInferior frontal cortexSuperior temporal gyrusLower activationMedial orbitofrontal cortexPosterior cingulate cortexHuman Connectome Project dataCognition tasksFacial emotionsNeural processesFrontal gyrusTemporal gyrusSelf-ReportNeural responses to negative facial emotions: Sex differences in the correlates of individual anger and fear traits
Li G, Zhang S, Le TM, Tang X, Li CR. Neural responses to negative facial emotions: Sex differences in the correlates of individual anger and fear traits. NeuroImage 2020, 221: 117171. PMID: 32682098, PMCID: PMC7789231, DOI: 10.1016/j.neuroimage.2020.117171.Peer-Reviewed Original ResearchConceptsNegative facial emotionsFacial emotionsMiddle frontal cortexShape targetRetrosplenial cortexEmotion processingIndividual differencesProlonged RTHigher activationRight middle frontal cortexLeft retrosplenial cortexBilateral middle frontal cortexFrontal cortexSex-specific behavioralShape identificationHuman Connectome ProjectRegional brain responsesEmotion measuresAffective traitsNeural processesBrain responsesFear traitsNeural responsesEmotional disordersIndividuals' angerNeural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity
Li G, Zhang S, Le TM, Tang X, Li CR. Neural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity. Cerebral Cortex Communications 2020, 1: tgaa025. PMID: 32864617, PMCID: PMC7446303, DOI: 10.1093/texcom/tgaa025.Peer-Reviewed Original ResearchGambling TaskNeural processesImpulse controlRegional activationSex differencesDorsal anterior cingulate cortexPrefrontal cortical activationAnterior cingulate cortexReaction timeHuman Connectome ProjectCautious respondingReward sensitivityIndividual variationNeural responsesBehavioral measuresAngular gyrusLonger reaction timesPrefrontal cortexImpulsivityCingulate cortexCortical activationConnectome ProjectHigher activationTaskReward
2019
Neural correlates of reward-directed action and inhibition of action
Le TM, Zhang S, Zhornitsky S, Wang W, Li CR. Neural correlates of reward-directed action and inhibition of action. Cortex 2019, 123: 42-56. PMID: 31747630, DOI: 10.1016/j.cortex.2019.10.007.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexInhibition of actionGo trialsReward-directed actionGoal-directed actionsInferior parietal cortexMiddle frontal cortexAnterior cingulate cortexMain effectSignificant main effectVisual attentionNeural correlatesGo taskResponse executionReward valuationNeural processesBrain activationHealthy human adultsNeural responsesReward magnitudeConjunction analysisLarge rewardDorsal ACCCingulate cortexParietal cortexInterdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Interdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action. Cerebral Cortex 2019, 30: 1662-1676. PMID: 31667492, PMCID: PMC7132903, DOI: 10.1093/cercor/bhz194.Peer-Reviewed Original ResearchConceptsInhibition of actionNeural correlatesReinforcement Sensitivity TheoryRostral anterior cingulate cortexMiddle frontal gyrusAnterior cingulate cortexPunishment sensitivityReinforcement sensitivityMFG activityIndividual differencesNeural processesReward QuestionnaireTrait sensitivityBrain correlatesNeural substratesFrontal gyrusGo responseRewarded actionsSensitivity theoryIncorrect responsesMediation analysisCingulate cortexRegional activationBehavioral approachAvoidance behaviorThe effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study
Wang W, Zhornitsky S, Chao HH, Levy I, Joormann J, Li CR. The effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study. Behavioural Brain Research 2019, 378: 112301. PMID: 31644928, PMCID: PMC6893150, DOI: 10.1016/j.bbr.2019.112301.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsSocial interactionSocial anxietyCyberball taskNeural processesOccipital cortexBall tossPregenual anterior cingulate cortexAnterior cingulate cortexSex differencesSocial exclusionAnxiety Scale scoresBehavioral performanceOrbitofrontal cortexCingulate cortexSubjective reportsBehavioral burdenEffect of ageObserved sex differencesYoung adultsCerebral responsesAge-related diminutionGame sessionsAnxietyCortexPosterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking
Le TM, Zhornitsky S, Wang W, Ide J, Zhang S, Li CR. Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. Journal Of Neuroscience 2019, 39: 6354-6364. PMID: 31189577, PMCID: PMC6687909, DOI: 10.1523/jneurosci.0508-19.2019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMaladaptive coping mechanismPunishment sensitivityNeural substratesBehavioral avoidanceResponse inhibitionNegative affectAlcohol usePosterior cingulate cortex activationCoping mechanismsProblem drinkingAlcohol misusePCC responseSensation-seeking traitsAvoidance strategiesAlcohol Use Disorders Identification TestHazardous alcohol useAvoidance tendenciesAlcohol Use Disorders Identification Test (AUDIT) scoresGo taskNeural processesReward QuestionnaireAction inhibitionBrain activationCerebral correlatesCue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activitySocial anxiety, posterior insula activation, and autonomic response during self-initiated action in a Cyberball game
Wang W, Zhornitsky S, Li CS, Le TM, Joormann J, Li CR. Social anxiety, posterior insula activation, and autonomic response during self-initiated action in a Cyberball game. Journal Of Affective Disorders 2019, 255: 158-167. PMID: 31153052, PMCID: PMC6591038, DOI: 10.1016/j.jad.2019.05.046.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsPosterior insula activationSocial anxietyCyberball gameInsula activationPhysiological arousalHigher skin conductance responsesHigh social anxietySevere social anxietyHigher physiological arousalSkin conductance responsesSkin conductance dataPotential sex effectsEffect of depressionSocial exclusionInsula responseNeural correlatesNeural processesLA individualsConductance responsesLimbic activationRegional activationSkin conductanceAnxietyLA group
2017
Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing
Chang A, Ide JS, Li HH, Chen CC, Li CR. Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing. ENeuro 2017, 4: eneuro.0061-17.2017. PMID: 28560315, PMCID: PMC5446487, DOI: 10.1523/eneuro.0061-17.2017.Peer-Reviewed Original ResearchConceptsStop-signal taskProactive controlConflict anticipationReaction timeTrial behavioral adjustmentsPrevious functional MRI studiesNeural oscillatory correlatesFunctional MRI studyDelta-theta bandLower theta bandDifferent behavioral paradigmsOscillatory correlatesNeural processesLow beta bandResponse slowingBehavioral adjustmentBehavioral paradigmsFunctional MRITime-frequency activityBehavioral strategiesElectrophysiological studiesElectrophysiological substrateMRI studiesBrain regionsRT clusters
2016
The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task
Manza P, Hu S, Ide JS, Farr OM, Zhang S, Leung HC, Li CR. The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task. Journal Of Psychopharmacology 2016, 30: 283-293. PMID: 26755547, PMCID: PMC4837899, DOI: 10.1177/0269881115625102.Peer-Reviewed Original ResearchConceptsUnsigned prediction errorsStop-signal taskConflict anticipationVentromedial prefrontal cortexEffects of methylphenidateDorsal anterior cingulateInferior parietal lobulePresupplementary motor areaCognitive controlHealthy young adultsNeural processesUpcoming conflictTask performanceNeural mechanismsBilateral caudate headParietal lobulePrediction errorPrefrontal cortexAnterior cingulateAdaptive behaviorParahippocampal gyrusMethylphenidateMotor areaAnticipation activityYoung adults
2015
Barratt Impulsivity and Neural Regulation of Physiological Arousal
Zhang S, Hu S, Hu J, Wu PL, Chao HH, Li CS. Barratt Impulsivity and Neural Regulation of Physiological Arousal. PLOS ONE 2015, 10: e0129139. PMID: 26079873, PMCID: PMC4469608, DOI: 10.1371/journal.pone.0129139.Peer-Reviewed Original ResearchConceptsSkin conductance responsesImpulsive individualsNeural basisPhysiological arousalArousal regulationHigh impulsivityBarratt impulsivitySkin conductanceGreater skin conductance responsesFunctional magnetic resonance imagingVentromedial prefrontal cortexStop-signal taskTheory of personalityBarratt Impulsivity ScalePoor impulse controlVmPFC activitySalient stimuliExternal stimulationImpulsive womenNeural processesNeural substratesSignal taskConductance responsesImpulsivity ScaleImpulsivityIndividual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits
Hu J, Lee D, Hu S, Zhang S, Chao H, Li CS. Individual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits. Brain Structure And Function 2015, 221: 2607-2618. PMID: 25989852, PMCID: PMC4654717, DOI: 10.1007/s00429-015-1061-4.Peer-Reviewed Original ResearchConceptsStop-signal taskHarm avoidanceNeural processesSignal taskPersonality traitsStudy of cognitionWhole-brain regressionRegional brain activationRisk-taking processesCognitive controlExecutive controlStop errorBrain activationFMRI studyBehavioral tasksMotor decisionsFrontopolar cortexMonetary rewardsNovelty seekingRisk-taking responsesBilateral orbitofrontalExplicit manipulationDorsomedial prefrontalRegional activationParahippocampal gyrus
2012
Neural Processes of an Indirect Analog of Risk Taking in Young Nondependent Adult Alcohol Drinkers—An fMRI Study of the Stop Signal Task
Bednarski SR, Erdman E, Luo X, Zhang S, Hu S, Li C. Neural Processes of an Indirect Analog of Risk Taking in Young Nondependent Adult Alcohol Drinkers—An fMRI Study of the Stop Signal Task. Alcohol Clinical And Experimental Research 2012, 36: 768-779. PMID: 22339607, PMCID: PMC3647608, DOI: 10.1111/j.1530-0277.2011.01672.x.Peer-Reviewed Original ResearchConceptsStop-signal taskAlcohol useNeural processesSignal taskSocial drinkingRisk takingYoung adult social drinkersFrequency of drinkingAdult social drinkersRight superior frontal gyrusFunctional magnetic resonanceSelf-reported alcohol useSuperior frontal gyrusBrain imaging dataSuperior frontal cortexDangerous alcohol consumptionCognitive factorsNeural correlatesFMRI studyFrontal gyrusSocial drinkersHigh-level drinkingCorresponding effect sizesNumber of drinksNondependent drinkers