The microRNA-195 - BDNF pathway and cognitive deficits in schizophrenia patients with minimal antipsychotic medication exposure
Pan S, Feng W, Li Y, Huang J, Chen S, Cui Y, Tian B, Tan S, Wang Z, Yao S, Chiappelli J, Kochunov P, Chen S, Yang F, Li CR, Tian L, Tan Y, Elliot Hong L. The microRNA-195 - BDNF pathway and cognitive deficits in schizophrenia patients with minimal antipsychotic medication exposure. Translational Psychiatry 2021, 11: 117. PMID: 33558459, PMCID: PMC7870897, DOI: 10.1038/s41398-021-01240-x.Peer-Reviewed Original ResearchConceptsBDNF protein levelsBrain-derived neurotrophic factorAntipsychotic medication exposureBDNF protein expressionMATRICS Consensus Cognitive BatteryMiR-195Medication exposureBDNF mRNABDNF proteinCognitive functionProtein levelsCognitive impairmentLower BDNF protein levelsCognitive deficitsSex-matched healthy controlsProtein expressionSubgroup of patientsFirst-episode patientsMiR-195 expressionBDNF reductionMedication-naïveNeurotrophic factorPeripheral bloodHealthy controlsOverall cognitive performance