2024
Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behavior
2019
Social anxiety, posterior insula activation, and autonomic response during self-initiated action in a Cyberball game
Wang W, Zhornitsky S, Li CS, Le TM, Joormann J, Li CR. Social anxiety, posterior insula activation, and autonomic response during self-initiated action in a Cyberball game. Journal Of Affective Disorders 2019, 255: 158-167. PMID: 31153052, PMCID: PMC6591038, DOI: 10.1016/j.jad.2019.05.046.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsPosterior insula activationSocial anxietyCyberball gameInsula activationPhysiological arousalHigher skin conductance responsesHigh social anxietySevere social anxietyHigher physiological arousalSkin conductance responsesSkin conductance dataPotential sex effectsEffect of depressionSocial exclusionInsula responseNeural correlatesNeural processesLA individualsConductance responsesLimbic activationRegional activationSkin conductanceAnxietyLA group
2016
Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait
Kann S, Zhang S, Manza P, Leung HC, Li C. Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait. Brain Connectivity 2016, 6: 724-734. PMID: 27604154, PMCID: PMC5105339, DOI: 10.1089/brain.2016.0443.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior insulaFunctional connectivityLaterality indexDorsomedial prefrontal cortexInferior frontal cortexAutomated Anatomic Labeling (AAL) atlasSuperior parietal lobuleCerebral functional organizationSuperior frontal gyrusPosterior orbital gyrusAttentional orientationAffective processingInsula activationRight lateralizationAffective controlLeft lateralizationSalient stimuliPhysiological arousalTridimensional Personality QuestionnaireFrontal gyrusHemispheric lateralizationSupramarginal gyrusLateralized connectivityParietal lobule