2019
Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activity
2006
Antisocial personality and stress-induced brain activation in cocaine-dependent patients
Li CS, Kosten TR, Sinha R. Antisocial personality and stress-induced brain activation in cocaine-dependent patients. Neuroreport 2006, 17: 243-247. PMID: 16462591, DOI: 10.1097/01.wnr.0000199471.06487.a2.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsDistress processingBrain activationStress imageryAntisocial personalitySocialization scoresFunctional magnetic resonance imaging studyAbstinent cocaine-dependent individualsRegional brain activationStress-induced brain activationFemale participantsMedial prefrontal cortexMagnetic resonance imaging studyResonance imaging studyNeural correlatesLower socialization scoresCocaine-dependent patientsCorticolimbic brain regionsPrefrontal cortexImportant sex differencesBrain regionsPersonalityInterest analysisSignificant activationEffect size
2005
Neuroimaging study of sex differences in the neuropathology of cocaine abuse
Li CS, Kemp K, Milivojevic V, Sinha R. Neuroimaging study of sex differences in the neuropathology of cocaine abuse. Gender Medicine 2005, 2: 174-182. PMID: 16290890, DOI: 10.1016/s1550-8579(05)80046-4.Peer-Reviewed Original ResearchConceptsRegional brain activationBrain activationGreater activationBrain regionsSex differencesScript-guided imagerySubstance abusersCerebral perfusion deficitsBlood oxygenation level-dependent (BOLD) signalSame statistical thresholdCocaine-dependent menCue-induced cravingSuperior frontal gyrusLevel-dependent signalChronic cocaine useMale substance abusersSex-related factorsCocaine use disorderImportant sex differencesLeft uncusStress trialsClinical outcomesPerfusion deficitsRight claustrumPharmacologic challenge