2024
Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampus
2021
Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace S, Rossetti MG, Allen N, Batalla A, Bellani M, Brambilla P, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Labuschagne I, Momenan R, Martin-Santos R, Rendell P, Solowij N, Sinha R, Li CR, Schmaal L, Sjoerds Z, Suo C, Terrett G, van Holst RJ, Veltman DJ, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Lorenzetti V. Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry 2021, 11: 156. PMID: 33664226, PMCID: PMC7933136, DOI: 10.1038/s41398-021-01204-1.Peer-Reviewed Original ResearchConceptsENIGMA Addiction Working GroupAlcohol dependenceAmygdala subregionsAlcohol-dependent malesUnderlying neurobiological mechanismsSex differencesSubfield volumesTotal amygdalaAlcohol doseBasolateral nucleusAnimal modelsMale controlsWorking GroupAmygdalar subregionsMental healthNeurobiological mechanismsComparison groupCognitive problemsHippocampusMalesFemalesDistinct mechanismsLittle evidenceGroupAmygdala