2021
The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia
Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong L, Tan Y. The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 828-835. PMID: 34263656, DOI: 10.1177/00048674211031478.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor levelsSerum brain-derived neurotrophic factor (BDNF) levelsNeurotrophic factor levelsFirst-episode schizophreniaQuestionnaire total scoreNegative Syndrome Scale total scoreChildhood Trauma Questionnaire total scoreScale total scoreNegative Syndrome ScaleFactor levelsTotal scoreChildhood traumaHealthy controlsLower serum brain-derived neurotrophic factor levelsAbnormal brain-derived neurotrophic factorChildhood traumatic experiencesSyndrome ScaleBrain-derived neurotrophic factorPathogenesis of schizophreniaEmotional neglectEnzyme-linked immunosorbentSevere childhood traumaChildhood Trauma QuestionnaireClinical symptomsNeurotrophic factor
2020
Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder
Wang L, Yin Y, Bian Q, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong LE, Tan Y. Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder. Journal Of Affective Disorders 2020, 278: 672-677. PMID: 33125910, DOI: 10.1016/j.jad.2020.10.029.Peer-Reviewed Original ResearchConceptsChildhood Trauma QuestionnaireDiagnosis of BDBipolar disorderBD-IIChildhood traumaTotal scoreImmature defense mechanismsImmature defense stylesImportant risk factorDefense Style QuestionnairePhysical neglectPsychosocial intervention strategiesDefense mechanismsEmotional abuseSevere childhood traumaBD patientsDefense stylesRisk factorsHealthy controlsHealthy volunteersChildhood traumatic experiencesPatientsDSM-IVTraumaTrauma Questionnaire