2022
Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia
Wang L, Zeng W, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Luo X, Tan S, Wang Z, Li C, Tian B, Tian L, Ma C, Li Y, Tan Y. Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia. Asian Journal Of Psychiatry 2022, 80: 103385. PMID: 36542893, DOI: 10.1016/j.ajp.2022.103385.Peer-Reviewed Original ResearchConceptsSensory gating deficitsFirst-episode schizophreniaGating deficitsS1-S2 differenceHealth controlsChildhood Trauma QuestionnaireChildhood trauma experiencesChildhood traumaS2/S1 ratioOnset of schizophreniaTrauma experiencesP50 sensory gatingSevere childhood traumaEmotional neglectSchizophrenia onsetS1 ratioSensory gatingAuditory conditioningEarly interventionCTQ totalSchizophreniaTraumaTrauma QuestionnaireStimulus paradigmPartial correlation analysisSubcortical structures associated with childhood trauma and perceived stress in schizophrenia
Fan F, Tan S, Liu S, Chen S, Huang J, Wang Z, Yang F, Li CR, Tan Y. Subcortical structures associated with childhood trauma and perceived stress in schizophrenia. Psychological Medicine 2022, 53: 5654-5662. PMID: 36154670, DOI: 10.1017/s0033291722002860.Peer-Reviewed Original ResearchConceptsGray matter volumeAmygdala gray matter volumeSubcortical gray matter volumesClinical symptomsEarly life traumaChildhood traumaSubcortical structuresCortical gray matter volumePerceived stressTotal cortical gray matter volumeAge-matched controlsSmaller amygdala volumesStructural brain imagingClinical featuresClinical manifestationsTrauma ScoreHealthy controlsChildhood trauma scoresLong-term effectsAmygdala volumePatientsMatter volumeEarly childhood traumaSmaller amygdalaVolumetric correlatesChildhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume
Wang L, Yin Y, Feng W, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Tian B, Tian L, Li CR, Tan Y. Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume. Journal Of Psychiatry And Neuroscience 2022, 47: e209-e217. PMID: 35654451, PMCID: PMC9177195, DOI: 10.1503/jpn.210178.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaCTQ total scoresHealthy controlsCognitive functionChildhood Trauma QuestionnaireTotal scoreCognitive deficitsChildhood trauma experiencesMATRICS Consensus Cognitive BatteryChildhood traumaOrbitofrontal cortexWorse cognitive functionTrauma experiencesHigh-resolution MRIRetrospective designPatientsConsensus Cognitive BatterySchizophreniaTraumaSubscoresSmall sample sizeTrauma QuestionnaireComposite scoreLines of evidenceScores
2021
Depression Mediates the Relationship between Childhood Trauma and Internet Addiction in Female but Not Male Chinese Adolescents and Young Adults
Dong X, Zhang R, Zhornitsky S, Le TM, Wang W, Li CR, Zhang S. Depression Mediates the Relationship between Childhood Trauma and Internet Addiction in Female but Not Male Chinese Adolescents and Young Adults. Journal Of Clinical Medicine 2021, 10: 5015. PMID: 34768534, PMCID: PMC8584624, DOI: 10.3390/jcm10215015.Peer-Reviewed Original ResearchChildhood traumaYoung adultsSex differencesPsychological risk factorsRisk factorsSevere depressionSignificant associationSociodemographic characteristicsTraumaFuture preventionControl participantsDepressionIntervention strategiesStandardized assessmentSeverityAddictionFemalesMalesEmotional neglectAdultsAdolescentsSexual abuseBehavioral addictionsThe mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia
Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong L, Tan Y. The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 828-835. PMID: 34263656, DOI: 10.1177/00048674211031478.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor levelsSerum brain-derived neurotrophic factor (BDNF) levelsNeurotrophic factor levelsFirst-episode schizophreniaQuestionnaire total scoreNegative Syndrome Scale total scoreChildhood Trauma Questionnaire total scoreScale total scoreNegative Syndrome ScaleFactor levelsTotal scoreChildhood traumaHealthy controlsLower serum brain-derived neurotrophic factor levelsAbnormal brain-derived neurotrophic factorChildhood traumatic experiencesSyndrome ScaleBrain-derived neurotrophic factorPathogenesis of schizophreniaEmotional neglectEnzyme-linked immunosorbentSevere childhood traumaChildhood Trauma QuestionnaireClinical symptomsNeurotrophic factor
2020
Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder
Wang L, Yin Y, Bian Q, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong LE, Tan Y. Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder. Journal Of Affective Disorders 2020, 278: 672-677. PMID: 33125910, DOI: 10.1016/j.jad.2020.10.029.Peer-Reviewed Original ResearchConceptsChildhood Trauma QuestionnaireDiagnosis of BDBipolar disorderBD-IIChildhood traumaTotal scoreImmature defense mechanismsImmature defense stylesImportant risk factorDefense Style QuestionnairePhysical neglectPsychosocial intervention strategiesDefense mechanismsEmotional abuseSevere childhood traumaBD patientsDefense stylesRisk factorsHealthy controlsHealthy volunteersChildhood traumatic experiencesPatientsDSM-IVTraumaTrauma Questionnaire