2022
Subcortical structures associated with childhood trauma and perceived stress in schizophrenia
Fan F, Tan S, Liu S, Chen S, Huang J, Wang Z, Yang F, Li CR, Tan Y. Subcortical structures associated with childhood trauma and perceived stress in schizophrenia. Psychological Medicine 2022, 53: 5654-5662. PMID: 36154670, DOI: 10.1017/s0033291722002860.Peer-Reviewed Original ResearchConceptsGray matter volumeAmygdala gray matter volumeSubcortical gray matter volumesClinical symptomsEarly life traumaChildhood traumaSubcortical structuresCortical gray matter volumePerceived stressTotal cortical gray matter volumeAge-matched controlsSmaller amygdala volumesStructural brain imagingClinical featuresClinical manifestationsTrauma ScoreHealthy controlsChildhood trauma scoresLong-term effectsAmygdala volumePatientsMatter volumeEarly childhood traumaSmaller amygdalaVolumetric correlates
2018
Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease
Manza P, Schwartz G, Masson M, Kann S, Volkow ND, Li CR, Leung HC. Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease. Neurobiology Of Aging 2018, 66: 12-22. PMID: 29501966, PMCID: PMC6436810, DOI: 10.1016/j.neurobiolaging.2018.02.003.Peer-Reviewed Original ResearchConceptsEarly-stage Parkinson's diseaseParkinson's diseaseDopaminergic medicationAdvanced Parkinson's diseaseStriatal activationResponse inhibitionRole of dopaminergicAge-matched controlsFunctional magnetic resonance imagingMagnetic resonance imagingExecutive functionLevodopa monotherapyMultiple medicationsMotor symptomsSignificant group differencesPD groupStop-signal taskAdvanced stageLevodopaResonance imagingMedicationsFunctional connectivityCritical executive functionMotor inhibitionPatients