2023
Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential age
2020
Age-Related Changes in the Neural Processes of Reward-Directed Action and Inhibition of Action
Le TM, Chao H, Levy I, Li CR. Age-Related Changes in the Neural Processes of Reward-Directed Action and Inhibition of Action. Frontiers In Psychology 2020, 11: 1121. PMID: 32587547, PMCID: PMC7298110, DOI: 10.3389/fpsyg.2020.01121.Peer-Reviewed Original ResearchInhibition of actionFunctional brain changesRostral anterior cingulate cortexWhole-brain multiple regressionAnterior cingulate cortexMiddle frontal gyrusAge-related changesFunctional magnetic resonanceBrain changesPostcentral gyrusCingulate cortexAnterior insulaFrontal gyrusTrialsProlonged response timeSuccess trialsGo trialsNeural activationReward-directed actionNegative modulationAgeAction inhibitionBrain substratesAge-related slowingReduced activity