2007
Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression
Petrakis I, Ralevski E, Nich C, Levinson C, Carroll K, Poling J, Rounsaville B. Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression. Journal Of Clinical Psychopharmacology 2007, 27: 160-165. PMID: 17414239, DOI: 10.1097/jcp.0b13e3180337fcb.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DeterrentsAlcoholismBipolar DisorderCocaine-Related DisordersComorbidityConnecticutDepressive Disorder, MajorDisulfiramDouble-Blind MethodDrug Therapy, CombinationFemaleGamma-GlutamyltransferaseGastrointestinal DiseasesHumansMaleMassachusettsMiddle AgedNaltrexoneNarcotic AntagonistsPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaStress Disorders, Post-TraumaticTreatment OutcomeVeteransConceptsPsychiatric symptomsAlcohol dependenceAlcohol use outcomesMajor depressionPsychiatric disordersVeterans Administration Outpatient ClinicHamilton Depression Rating ScaleAxis I psychiatric disordersCommon co-occurring disordersDouble-blind randomizationUse outcomesGamma-glutamyltransferase levelsDepression Rating ScaleFourth Edition criteriaDiagnosis of depressionCo-occurring disordersSpecific psychiatric symptomsTreatment of alcoholismAlcohol use disorderOpen randomizationAdverse eventsMedication groupSecondary outcomesPrimary outcomeMedication treatment
2006
Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Post-Traumatic Stress Disorder
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Ralevski E, Rounsaville B. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Post-Traumatic Stress Disorder. Biological Psychiatry 2006, 60: 777-783. PMID: 17008146, DOI: 10.1016/j.biopsych.2006.03.074.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderAlcohol dependencePsychiatric symptomsComorbid post-traumatic stress disorderVeterans Administration Outpatient ClinicStress disorderAxis I psychiatric disordersBetter alcohol outcomesDouble-blind randomizationOverall psychiatric symptomsDSM-IV criteriaTreatment of alcoholismOpen randomizationActive medicationAdverse eventsAlcohol use outcomesOutpatient clinicGGT levelsMedication studiesPsychiatric disordersSide effectsNaltrexoneAlcohol cravingDrug AdministrationPlacebo
2005
Psychotic Spectrum Disorders and Alcohol Abuse: A Review of Pharmacotherapeutic Strategies and a Report on the Effectiveness of Naltrexone and Disulfiram
Petrakis IL, Nich C, Ralevski E. Psychotic Spectrum Disorders and Alcohol Abuse: A Review of Pharmacotherapeutic Strategies and a Report on the Effectiveness of Naltrexone and Disulfiram. Schizophrenia Bulletin 2005, 32: 644-654. PMID: 16887890, PMCID: PMC2632271, DOI: 10.1093/schbul/sbl010.Peer-Reviewed Original ResearchConceptsPsychotic spectrum disordersPharmacotherapeutic strategiesSchizoaffective disorderBipolar disorderMental illnessAlcohol dependenceBetter alcohol use outcomesEffectiveness of naltrexoneIntensive psychosocial treatmentComorbid mental illnessUse of disulfiramAxis I DisordersSubstance use disordersSpectrum disorderActive medicationAlcohol use outcomesPharmacotherapeutic optionsSignificant morbidityMedication complianceClinical trialsI disordersPsychosocial treatmentsGeneral populationSpecific treatmentAlcohol abuseNaltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, Group V. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders. Biological Psychiatry 2005, 57: 1128-1137. PMID: 15866552, DOI: 10.1016/j.biopsych.2005.02.016.Peer-Reviewed Original ResearchConceptsPsychiatric disordersAlcohol dependenceVeterans Administration Outpatient ClinicAxis I psychiatric disordersComorbid psychiatric disordersUse of disulfiramTreatment of alcoholismEvent Monitoring SystemAlcohol-dependent individualsActive medicationAdverse eventsSecondary outcomesPrimary outcomeMedication complianceOutpatient clinicSignificant group differencesGGT levelsMedication studiesPsychiatric symptomsAlcohol consumptionNaltrexoneAlcohol cravingDrug AdministrationConsecutive weeksPlacebo
2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential responseCost effectiveness of disulfiram Treating cocaine use in methadone-maintained patients
Jofre-Bonet M, Sindelar JL, Petrakis IL, Nich C, Frankforter T, Rounsaville BJ, Carroll KM. Cost effectiveness of disulfiram Treating cocaine use in methadone-maintained patients. Journal Of Substance Use And Addiction Treatment 2004, 26: 225-232. PMID: 15063917, PMCID: PMC3662046, DOI: 10.1016/s0740-5472(04)00004-2.Peer-Reviewed Original ResearchConceptsMethadone treatmentClinical trialsCocaine useDouble-blind clinical trialCocaine dependenceStandard methadone treatmentBlind clinical trialMethadone-maintained patientsRandomized clinical trialsOpioid-dependent subjectsMethadone-maintained opiate addictsStandard treatmentOutcome measuresOpioid addictsPromising treatmentOpiate addictsIncremental costDisulfiramAdditional treatmentNumber of daysTrialsTreatmentCost effectivenessEconomic evaluationAddicts