2018
Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
Carroll KM, Nich C, DeVito EE, Shi JM, Sofuoglu M. Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. The Journal Of Clinical Psychiatry 2018, 79: 17m11669. PMID: 29286595, PMCID: PMC5866530, DOI: 10.4088/jcp.17m11669.Peer-Reviewed Original ResearchConceptsComputerized cognitive behavioral therapyStandard methadone treatmentCocaine use outcomesBenefits of galantamineMethadone treatmentCognitive behavioral therapyCognitive functionUse outcomesCommunity-based methadone maintenance programCocaine useStandard methadone maintenance treatmentBehavioral therapyUrine toxicology screenMethadone maintenance treatmentMethadone maintenance programCocaine treatment outcomesNicotinic acetylcholine receptorsCognitive functioningCocaine use disorderMethadone dosingSecondary outcomesToxicology screenMaintenance treatmentClinical trialsMedication administration
2016
A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence
Carroll KM, Nich C, Petry NM, Eagan DA, Shi JM, Ball SA. A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence. Drug And Alcohol Dependence 2016, 160: 135-142. PMID: 26817621, PMCID: PMC4767616, DOI: 10.1016/j.drugalcdep.2015.12.036.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCocaine outcomesCocaine dependenceCombination of CMDouble-blind clinical trialBehavioral therapyCommunity-based outpatient clinicsUrine sample testingBlind clinical trialSustained treatment effectContingency managementDSM-IV criteriaRandomized factorial trialCurrent cocaine dependenceWeekly individual sessionsCocaine use disorderSecondary outcomesPrimary outcomeYear followOutpatient clinicAddition of disulfiramClinical trialsUse disordersCBT treatmentFactorial trial
2015
Alexithymia level and response to computer-based training in cognitive behavioral therapy among cocaine-dependent methadone maintained individuals
Morie KP, Nich C, Hunkele K, Potenza MN, Carroll KM. Alexithymia level and response to computer-based training in cognitive behavioral therapy among cocaine-dependent methadone maintained individuals. Drug And Alcohol Dependence 2015, 152: 157-163. PMID: 25982006, PMCID: PMC4458169, DOI: 10.1016/j.drugalcdep.2015.04.004.Peer-Reviewed Original ResearchPrompted to treatment by the criminal justice system: Relationships with treatment retention and outcome among cocaine users
Kiluk BD, Serafini K, Malin-Mayor B, Babuscio TA, Nich C, Carroll KM. Prompted to treatment by the criminal justice system: Relationships with treatment retention and outcome among cocaine users. American Journal On Addictions 2015, 24: 225-232. PMID: 25809378, PMCID: PMC4494106, DOI: 10.1111/ajad.12208.Peer-Reviewed Original Research
2014
Computer-Assisted Delivery of Cognitive-Behavioral Therapy: Efficacy and Durability of CBT4CBT Among Cocaine-Dependent Individuals Maintained on Methadone
Carroll KM, Kiluk BD, Nich C, Gordon MA, Portnoy GA, Marino DR, Ball SA. Computer-Assisted Delivery of Cognitive-Behavioral Therapy: Efficacy and Durability of CBT4CBT Among Cocaine-Dependent Individuals Maintained on Methadone. American Journal Of Psychiatry 2014, 171: 436-444. PMID: 24577287, PMCID: PMC4042674, DOI: 10.1176/appi.ajp.2013.13070987.Peer-Reviewed Original ResearchMeSH KeywordsAdultCocaine-Related DisordersCognitive Behavioral TherapyCombined Modality TherapyFemaleHumansMaleMethadoneMiddle AgedNarcoticsTherapy, Computer-AssistedTreatment OutcomeConceptsCocaine-dependent individualsCognitive behavioral therapyMethadone maintenanceCommunity-based outpatient clinicsPrevious pilot trialMethadone maintenance programStandard methadone maintenanceDisseminable strategyDefinitive trialOutpatient clinicClinical trialsEffective adjunctPilot trialTreatment terminationTreatment retentionBetter outcomesConsecutive weeksCBT4CBTWeekly accessAddiction treatmentDurable effectsTrialsSubstance usersStatistical significanceMethadone
2013
An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence–contingent incentives and cognitive behavioral therapy
Krishnan-Sarin S, Cavallo DA, Cooney JL, Schepis TS, Kong G, Liss TB, Liss AK, McMahon TJ, Nich C, Babuscio T, Rounsaville BJ, Carroll KM. An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence–contingent incentives and cognitive behavioral therapy. Drug And Alcohol Dependence 2013, 132: 346-351. PMID: 23523130, PMCID: PMC3748248, DOI: 10.1016/j.drugalcdep.2013.03.002.Peer-Reviewed Original ResearchConceptsSmoking cessation interventionCognitive behavioral therapyAbstinence-contingent incentivesAdolescent smokersCessation interventionsBehavioral therapyCigarette useEffective smoking cessation interventionsUrine cotinine levelsPoint prevalence abstinenceShort-term abstinenceSecondary outcomesCotinine levelsPrimary outcomeCessation treatmentCessation barriersCessation skillsFirst cigaretteFollow-upSmokersHigher abstinenceSurvival analysisNovel interventionsFour weeksHigh school
2012
Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less
Carroll KM, Nich C, LaPaglia DM, Peters EN, Easton CJ, Petry NM. Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less. Addiction 2012, 107: 1650-1659. PMID: 22404223, PMCID: PMC3509418, DOI: 10.1111/j.1360-0443.2012.03877.x.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyContingency managementHomework completionTime-line follow-back methodTreatment-seeking young adultsCannabis dependenceAddition of CBTSession attendanceOut-patient treatment programDays of cannabisCannabis treatment outcomesCBT outcomeBehavioral therapyAbstinence conditionSkills trainingRandom effects regression analysisAlone conditionCriminal justice systemUrine specimensTreatment programYoung adultsWeekly urineEffects regression analysisJustice systemAbstinence
2009
d-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: A pilot investigation
Santa Ana EJ, Rounsaville BJ, Frankforter TL, Nich C, Babuscio T, Poling J, Gonsai K, Hill KP, Carroll KM. d-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: A pilot investigation. Drug And Alcohol Dependence 2009, 104: 220-227. PMID: 19592176, PMCID: PMC2791457, DOI: 10.1016/j.drugalcdep.2009.04.023.Peer-Reviewed Original ResearchConceptsSmoking cuesCue exposure therapyExposure therapyD-cycloserineVivo smoking cuesBehavioral exposure therapyCue exposure treatmentNicotine dependenceNicotine-dependent smokersPilot laboratory studyCue reactivitySubjective urgePhysiological reactivityExposure treatmentCuesDependent smokersAbstinence of smokingPlace preferenceSmoking behaviorExpired carbon monoxide levelsPilot investigationExploratory analysisGeneral communityOne weekPrior studies
2005
Psychotic Spectrum Disorders and Alcohol Abuse: A Review of Pharmacotherapeutic Strategies and a Report on the Effectiveness of Naltrexone and Disulfiram
Petrakis IL, Nich C, Ralevski E. Psychotic Spectrum Disorders and Alcohol Abuse: A Review of Pharmacotherapeutic Strategies and a Report on the Effectiveness of Naltrexone and Disulfiram. Schizophrenia Bulletin 2005, 32: 644-654. PMID: 16887890, PMCID: PMC2632271, DOI: 10.1093/schbul/sbl010.Peer-Reviewed Original ResearchConceptsPsychotic spectrum disordersPharmacotherapeutic strategiesSchizoaffective disorderBipolar disorderMental illnessAlcohol dependenceBetter alcohol use outcomesEffectiveness of naltrexoneIntensive psychosocial treatmentComorbid mental illnessUse of disulfiramAxis I DisordersSubstance use disordersSpectrum disorderActive medicationAlcohol use outcomesPharmacotherapeutic optionsSignificant morbidityMedication complianceClinical trialsI disordersPsychosocial treatmentsGeneral populationSpecific treatmentAlcohol abuse
2004
Ethnic Differences in Substance Abuse Treatment Retention, Compliance, and Outcome From Two Clinical Trials
Milligan CO, Nich C, Carroll KM. Ethnic Differences in Substance Abuse Treatment Retention, Compliance, and Outcome From Two Clinical Trials. Psychiatric Services 2004, 55: 167-173. PMID: 14762242, PMCID: PMC3666311, DOI: 10.1176/appi.ps.55.2.167.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAntidepressive Agents, TricyclicBlack PeopleCocaine-Related DisordersCognitive Behavioral TherapyCombined Modality TherapyConnecticutDesipramineDisulfiramEnzyme InhibitorsFemaleHumansMalePatient CompliancePatient DropoutsRetrospective StudiesTreatment OutcomeWhite PeopleConceptsCocaine use outcomesTreatment expectationsTreatment retentionAfrican AmericansUse outcomesExpectations of treatmentSubstance abuse treatment retentionDays of treatmentDifferent behavioral treatmentsClinical trialsPretreatment characteristicsAfrican American participantsMedication componentsCocaine dependence
2001
Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement
Carroll KM, Ball SA, Nich C, O'Connor PG, Eagan DA, Frankforter TL, Triffleman EG, Shi J, Rounsaville BJ. Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement. JAMA Psychiatry 2001, 58: 755-761. PMID: 11483141, PMCID: PMC3651594, DOI: 10.1001/archpsyc.58.8.755.Peer-Reviewed Original ResearchConceptsDrug-free urine specimensNaltrexone treatmentFamily counseling sessionsContingency managementOpioid dependenceTreatment retentionUrine specimensBehavioral therapyOpioid-dependent individualsCounseling sessionsDrug use outcomesSubstance abuse outcomesNaltrexone complianceNaltrexone therapyOpioid useAvailable pharmacotherapiesMedication complianceSpecific pharmacotherapySignificant improvementTherapyUse outcomesAbuse outcomesPrincipal outcomePharmacotherapyTreatment
2000
One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment
Carroll K, Nich C, Ball S, McCance E, Frankforter T, Rounsaville B. One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment. Addiction 2000, 95: 1335-1349. PMID: 11048353, DOI: 10.1046/j.1360-0443.2000.95913355.x.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentTwelve-step facilitationInitiation of abstinenceAlcohol useSubstance abuse treatment centersFrequency of cocaineAlcohol-dependent individualsClinical managementMain effectBrief treatmentEfficacy of disulfiramUrine toxicology screenCessation of treatmentBreathalyzer testEnd of treatmentOutcomes 1 yearAbstinencePercentage of daysEffect of treatmentCocaineLong-term benefitsToxicology screenTreatment centersBetter outcomesBrief periodA general system for evaluating therapist adherence and competence in psychotherapy research in the addictions
Carroll K, Nich C, Sifry R, Nuro K, Frankforter T, Ball S, Fenton L, Rounsaville B. A general system for evaluating therapist adherence and competence in psychotherapy research in the addictions. Drug And Alcohol Dependence 2000, 57: 225-238. PMID: 10661673, DOI: 10.1016/s0376-8716(99)00049-6.Peer-Reviewed Original ResearchConceptsTherapist adherenceRandomized clinical trialsSubstance use disordersDrug abuse treatmentYale AdherenceClinical trialsPharmacotherapy researchUse disordersBehavioral treatmentAbuse treatmentClinical researchAdherenceTreatmentComparison treatmentCompetence scoresExcellent reliabilityAddictionDiscriminant validityCompetence ScaleFactor structurePsychotherapy research
1998
Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram
Carroll KM, Nich C, Ball SA, McCance E, Rounsavile BJ. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 1998, 93: 713-727. PMID: 9692270, DOI: 10.1046/j.1360-0443.1998.9357137.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcoholismCocaineCognitive Behavioral TherapyCombined Modality TherapyDisulfiramFemaleHumansMaleSubstance-Related DisordersConceptsCognitive-behavioral treatmentAlcohol useClinical managementCocaine useConcurrent alcohol abuseDrug use disordersTreatment of cocaineCo-morbid disordersPromising treatment strategySubstance abuse treatment centersTreatment-seeking cocaine abusersUrine toxicologyDrug-dependent individualsContinuous abstinenceDisulfiram treatmentStep FacilitationTreatment strategiesCocaine-dependent individualsAlcohol abuseAlcohol abusersUse disordersTreatment centersSupportive psychotherapyAlcohol dependenceActive psychotherapy
1995
Differential Symptom Reduction in Depressed Cocaine Abusers Treated with Psychotherapy and Pharmacotherapy
CARROLL K, NICH C, ROUNSAVILLE B. Differential Symptom Reduction in Depressed Cocaine Abusers Treated with Psychotherapy and Pharmacotherapy. The Journal Of Nervous And Mental Disease 1995, 183: 251-259. PMID: 7714514, DOI: 10.1097/00005053-199504000-00012.Peer-Reviewed Original ResearchConceptsDepressive symptomsSymptom reductionCocaine abusersTrial of desipramineRelapse prevention treatmentSupportive clinical managementGreater reductionEuthymic subgroupPsychotherapy conditionsDesipramine treatmentEffective antidepressantDepressed subgroupClinical managementCognitive-behavioral treatmentTreatment responsePrevention treatmentCocaine outcomesAmbulatory cocaine abusersDepressive symptomatologyCocaine useCocaine addictsConsecutive abstinenceIntegrating psychotherapy and pharmacotherapy for cocaine dependence: results from a randomized clinical trial.
Carroll KM, Rounsaville BJ, Nich C, Gordon L, Gawin F. Integrating psychotherapy and pharmacotherapy for cocaine dependence: results from a randomized clinical trial. NIDA Research Monograph 1995, 150: 19-35. PMID: 8742770.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive Agents, TricyclicCocaineCognitive Behavioral TherapyCombined Modality TherapyDesipramineFemaleHumansMaleOpioid-Related DisordersPsychotherapyConceptsRandomized clinical trials
1994
Blind Man’s Bluff: Effectiveness and Significance of Psychotherapy and Pharmacotherapy Blinding Procedures in a Clinical Trial
Carroll K, Rounsaville B, Nich C. Blind Man’s Bluff: Effectiveness and Significance of Psychotherapy and Pharmacotherapy Blinding Procedures in a Clinical Trial. Journal Of Consulting And Clinical Psychology 1994, 62: 276-280. PMID: 8201064, DOI: 10.1037/0022-006x.62.2.276.Peer-Reviewed Original ResearchMeSH KeywordsCocaineCombined Modality TherapyDesipramineDouble-Blind MethodHumansPsychotherapySubstance-Related DisordersTreatment OutcomePsychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers
Carroll KM, Rounsaville BJ, Gordon LT, Nich C, Jatlow P, Bisighini RM, Gawin FH. Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers. JAMA Psychiatry 1994, 51: 177-187. PMID: 8122955, DOI: 10.1001/archpsyc.1994.03950030013002.Peer-Reviewed Original ResearchConceptsClinical managementCocaine useCocaine abusersRelapse preventionAmbulatory cocaine abusersWeeks of treatmentForm of treatmentHigh-severity patientsInitiation trialsAbstinence initiationBaseline severityClinical trialsEffective treatmentTreatment retentionBetter outcomesCocaine abusePharmacotherapyDepressed subjectsPlaceboDesipramine hydrochlorideSpecialized treatmentDesipraminePreventionGreater reductionDistinct subgroups