2013
Smokers Versus Snorters: Do Treatment Outcomes Differ According to Route of Cocaine Administration?
Kiluk BD, Babuscio TA, Nich C, Carroll KM. Smokers Versus Snorters: Do Treatment Outcomes Differ According to Route of Cocaine Administration? Experimental And Clinical Psychopharmacology 2013, 21: 490-498. PMID: 24364538, PMCID: PMC3943602, DOI: 10.1037/a0034173.Peer-Reviewed Original ResearchConceptsTreatment outcomesCocaine administrationAddiction Severity Index composite scoresIntranasal usersComposite scoreRoute of administrationCocaine use outcomesPrimary routeIntranasal routeClinical trialsSustained abstinenceCocaine-dependent individualsTreatment phaseSmokersCocaine useStudy periodAdministrationUse outcomesSeverity of problemsMaximal concentrationStatistical significanceASI domainsOutcomesDifferential changesCocaine
2007
The Impact of Personality Disorders on Alcohol‐Use Outcomes in a Pharmacotherapy Trial for Alcohol Dependence and Comorbid Axis I Disorders
Ralevski E, Ball S, Nich C, Limoncelli D, Petrakis I. The Impact of Personality Disorders on Alcohol‐Use Outcomes in a Pharmacotherapy Trial for Alcohol Dependence and Comorbid Axis I Disorders. American Journal On Addictions 2007, 16: 443-449. PMID: 18058408, DOI: 10.1080/10550490701643336.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcoholismAntisocial Personality DisorderBehavior, AddictiveBorderline Personality DisorderComorbidityDiagnostic and Statistical Manual of Mental DisordersDisulfiramFemaleHumansMaleMental DisordersMiddle AgedNaltrexoneNarcotic AntagonistsPatient CompliancePersonality DisordersPlacebosPsychiatric Status Rating ScalesTreatment OutcomeConceptsBorderline personality disorderAxis I DisordersAlcohol dependenceAlcohol use outcomesPersonality disorderI disordersAxis IComorbid Axis I disordersContext of pharmacotherapyAxis II disordersMajor Axis IMedication trialsPharmacotherapy trialsPoor responseOutcome measuresPatientsNaltrexoneAlcohol useDiagnosisUse outcomesDiagnosis of antisocialDisordersDisulfiramOutcomesASPDNaltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression
Petrakis I, Ralevski E, Nich C, Levinson C, Carroll K, Poling J, Rounsaville B. Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression. Journal Of Clinical Psychopharmacology 2007, 27: 160-165. PMID: 17414239, DOI: 10.1097/jcp.0b13e3180337fcb.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DeterrentsAlcoholismBipolar DisorderCocaine-Related DisordersComorbidityConnecticutDepressive Disorder, MajorDisulfiramDouble-Blind MethodDrug Therapy, CombinationFemaleGamma-GlutamyltransferaseGastrointestinal DiseasesHumansMaleMassachusettsMiddle AgedNaltrexoneNarcotic AntagonistsPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaStress Disorders, Post-TraumaticTreatment OutcomeVeteransConceptsPsychiatric symptomsAlcohol dependenceAlcohol use outcomesMajor depressionPsychiatric disordersVeterans Administration Outpatient ClinicHamilton Depression Rating ScaleAxis I psychiatric disordersCommon co-occurring disordersDouble-blind randomizationUse outcomesGamma-glutamyltransferase levelsDepression Rating ScaleFourth Edition criteriaDiagnosis of depressionCo-occurring disordersSpecific psychiatric symptomsTreatment of alcoholismAlcohol use disorderOpen randomizationAdverse eventsMedication groupSecondary outcomesPrimary outcomeMedication treatmentA Cognitive Behavioral Therapy for Alcohol‐Dependent Domestic Violence Offenders: An Integrated Substance Abuse–Domestic Violence Treatment Approach (SADV)
Easton CJ, Mandel DL, Hunkele KA, Nich C, Rounsaville BJ, Carroll KM. A Cognitive Behavioral Therapy for Alcohol‐Dependent Domestic Violence Offenders: An Integrated Substance Abuse–Domestic Violence Treatment Approach (SADV). American Journal On Addictions 2007, 16: 24-31. PMID: 17364418, DOI: 10.1080/10550490601077809.Peer-Reviewed Original ResearchConceptsAlcohol-dependent malesHistory of IPVCognitive-behavioral group therapyInterpersonal violenceBehavioral group therapyCognitive behavioral therapyGroup therapy approachSubstance abuse treatmentDomestic violence offendersBehavioral therapyDomestic violence groupGroup therapyAbuse treatmentNumber of sessionsSubstance use
2005
Psychotic Spectrum Disorders and Alcohol Abuse: A Review of Pharmacotherapeutic Strategies and a Report on the Effectiveness of Naltrexone and Disulfiram
Petrakis IL, Nich C, Ralevski E. Psychotic Spectrum Disorders and Alcohol Abuse: A Review of Pharmacotherapeutic Strategies and a Report on the Effectiveness of Naltrexone and Disulfiram. Schizophrenia Bulletin 2005, 32: 644-654. PMID: 16887890, PMCID: PMC2632271, DOI: 10.1093/schbul/sbl010.Peer-Reviewed Original ResearchConceptsPsychotic spectrum disordersPharmacotherapeutic strategiesSchizoaffective disorderBipolar disorderMental illnessAlcohol dependenceBetter alcohol use outcomesEffectiveness of naltrexoneIntensive psychosocial treatmentComorbid mental illnessUse of disulfiramAxis I DisordersSubstance use disordersSpectrum disorderActive medicationAlcohol use outcomesPharmacotherapeutic optionsSignificant morbidityMedication complianceClinical trialsI disordersPsychosocial treatmentsGeneral populationSpecific treatmentAlcohol abuse
2000
A general system for evaluating therapist adherence and competence in psychotherapy research in the addictions
Carroll K, Nich C, Sifry R, Nuro K, Frankforter T, Ball S, Fenton L, Rounsaville B. A general system for evaluating therapist adherence and competence in psychotherapy research in the addictions. Drug And Alcohol Dependence 2000, 57: 225-238. PMID: 10661673, DOI: 10.1016/s0376-8716(99)00049-6.Peer-Reviewed Original ResearchConceptsTherapist adherenceRandomized clinical trialsSubstance use disordersDrug abuse treatmentYale AdherenceClinical trialsPharmacotherapy researchUse disordersBehavioral treatmentAbuse treatmentClinical researchAdherenceTreatmentComparison treatmentCompetence scoresExcellent reliabilityAddictionDiscriminant validityCompetence ScaleFactor structurePsychotherapy research
1995
Differential Symptom Reduction in Depressed Cocaine Abusers Treated with Psychotherapy and Pharmacotherapy
CARROLL K, NICH C, ROUNSAVILLE B. Differential Symptom Reduction in Depressed Cocaine Abusers Treated with Psychotherapy and Pharmacotherapy. The Journal Of Nervous And Mental Disease 1995, 183: 251-259. PMID: 7714514, DOI: 10.1097/00005053-199504000-00012.Peer-Reviewed Original ResearchConceptsDepressive symptomsSymptom reductionCocaine abusersTrial of desipramineRelapse prevention treatmentSupportive clinical managementGreater reductionEuthymic subgroupPsychotherapy conditionsDesipramine treatmentEffective antidepressantDepressed subgroupClinical managementCognitive-behavioral treatmentTreatment responsePrevention treatmentCocaine outcomesAmbulatory cocaine abusersDepressive symptomatologyCocaine useCocaine addictsConsecutive abstinence