2002
‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data
Nich C, Carroll KM. ‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data. Drug And Alcohol Dependence 2002, 68: 121-130. PMID: 12234641, PMCID: PMC3651592, DOI: 10.1016/s0376-8716(02)00111-4.Peer-Reviewed Original ResearchConceptsEffectiveness of treatmentTreat analysisClinical trialsRandomized clinical trialsClinical trial dataStudy treatmentProtocol violationsTreat strategyTreatment retentionPoint of dropoutTime-varying covariatesTrial dataCocaine dependenceIntended durationParticipant dropoutRelative efficacyTrialsTreatmentMultiple analytic strategiesRetention outcomesDurationFull durationStrategy 1Analytic strategiesSubstantial levels
1997
Variability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials.
Carroll KM, Nich C, Rounsaville BJ. Variability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials. NIDA Research Monograph 1997, 175: 137-57. PMID: 9467796.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicCocaineHumansNarcoticsPatient Acceptance of Health CareResearch DesignSubstance-Related DisordersConceptsPatient-treatment interactionsTreatment responseCocaine abusersClinical pharmacotherapy trialsChallenging patient populationEffective pharmacological interventionsStudy sampleSpecific treatment strategiesTreatment-seeking cocaine abusersPatient populationPharmacotherapy trialsMedication effectsNew medicationsPharmacologic agentsTreatment responsivenessPharmacological interventionsPharmacotherapy researchTreatment strategiesLarger sample sizeCocaine dependenceComparison of findingsTreatment seekingStandardized assessmentSimple main effectsInconsistent findings