2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMen
2011
A Methodological Analysis of Randomized Clinical Trials of Computer-Assisted Therapies for Psychiatric Disorders: Toward Improved Standards for an Emerging Field
Kiluk BD, Sugarman DE, Nich C, Gibbons CJ, Martino S, Rounsaville BJ, Carroll KM. A Methodological Analysis of Randomized Clinical Trials of Computer-Assisted Therapies for Psychiatric Disorders: Toward Improved Standards for an Emerging Field. American Journal Of Psychiatry 2011, 168: 790-799. PMID: 21536689, PMCID: PMC3607199, DOI: 10.1176/appi.ajp.2011.10101443.Peer-Reviewed Original ResearchConceptsComputer-assisted therapyRandomized clinical trialsPsychiatric disordersClinical trialsMethodological qualityEvidence-based behavioral therapiesMethodological Quality IndexPotential adverse eventsEvidence-based therapiesAxis I DisordersAdult psychiatric disordersMethodological quality scoreEvidence-based interventionsAdverse eventsTreat principleRandomized trialsI disordersStudy qualityTreatment exposureTherapyBehavioral therapyCost-effective strategyDisordersTrialsCurrent standard
2010
Informal discussions in substance abuse treatment sessions with Spanish-speaking clients
Bamatter W, Carroll KM, Añez LM, Paris M, Ball SA, Nich C, Frankforter TL, Suarez-Morales L, Szapocznik J, Martino S. Informal discussions in substance abuse treatment sessions with Spanish-speaking clients. Journal Of Substance Use And Addiction Treatment 2010, 39: 353-363. PMID: 20817381, PMCID: PMC2967664, DOI: 10.1016/j.jsat.2010.07.005.Peer-Reviewed Original ResearchConceptsMotivational enhancement therapyStandard treatmentDrug Abuse Clinical Trials Network protocolTreatment sessionsSubstance abuse treatment outcomesSignificant inverse correlationHispanic clientsEarly treatment sessionsSession audiotapesTreatment outcomesSubstance abuse treatment sessionsEnhancement therapyClient motivationSubstance useInverse correlationTreatment fidelityNational InstituteTreatmentAdverse consequencesTrialsSessionsClient retentionMonolingual Spanish
2009
A Multisite Randomized Effectiveness Trial of Motivational Enhancement Therapy for Spanish-Speaking Substance Users
Carroll KM, Martino S, Ball SA, Nich C, Frankforter T, Anez LM, Paris M, Suarez-Morales L, Szapocznik J, Miller WR, Rosa C, Matthews J, Farentinos C. A Multisite Randomized Effectiveness Trial of Motivational Enhancement Therapy for Spanish-Speaking Substance Users. Journal Of Consulting And Clinical Psychology 2009, 77: 993-999. PMID: 19803579, PMCID: PMC2792592, DOI: 10.1037/a0016489.Peer-Reviewed Original ResearchConceptsMotivational enhancement therapyEnhancement therapySubstance useSubstance usersRandomized Effectiveness TrialIndividual sessionsCurrent substance useX time interactionTreatment condition interactionCondition x time interactionSubstance use problemsClinical trialsEffectiveness trialTreatment exposureTherapy phaseTreatment retentionTreatment sessionsHispanic adultsTherapyHeterogeneous groupHispanic individualsTime interactionIndividual treatmentTrialsUse problemsd-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: A pilot investigation
Santa Ana EJ, Rounsaville BJ, Frankforter TL, Nich C, Babuscio T, Poling J, Gonsai K, Hill KP, Carroll KM. d-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: A pilot investigation. Drug And Alcohol Dependence 2009, 104: 220-227. PMID: 19592176, PMCID: PMC2791457, DOI: 10.1016/j.drugalcdep.2009.04.023.Peer-Reviewed Original ResearchConceptsSmoking cuesCue exposure therapyExposure therapyD-cycloserineVivo smoking cuesBehavioral exposure therapyCue exposure treatmentNicotine dependenceNicotine-dependent smokersPilot laboratory studyCue reactivitySubjective urgePhysiological reactivityExposure treatmentCuesDependent smokersAbstinence of smokingPlace preferenceSmoking behaviorExpired carbon monoxide levelsPilot investigationExploratory analysisGeneral communityOne weekPrior studiesCorrespondence of motivational enhancement treatment integrity ratings among therapists, supervisors, and observers
Martino S, Ball S, Nich C, Frankforter TL, Carroll KM. Correspondence of motivational enhancement treatment integrity ratings among therapists, supervisors, and observers. Psychotherapy Research 2009, 19: 181-193. PMID: 19396649, PMCID: PMC2782382, DOI: 10.1080/10503300802688460.Peer-Reviewed Original ResearchConceptsMotivational enhancement therapyDrug Abuse Clinical Trials Network protocolTraining therapistsEnhancement therapyTherapist performanceGroups of ratersTherapeutic processSupervisorsTherapistsTreatment implementationRatingsCommunity programsDifferent perspectivesObserverCompetenceNational InstituteObjective monitoringRatersPerformanceFindingsCorrespondencePerspective
2001
Perspective is everything: the predictive validity of six working alliance instruments.
Fenton LR, Cecero JJ, Nich C, Frankforter TL, Carroll KM. Perspective is everything: the predictive validity of six working alliance instruments. American Journal Of Psychotherapy 2001, 10: 262-8. PMID: 11696653, PMCID: PMC3330662.Peer-Reviewed Original ResearchConceptsObserver-rated instrumentsAlliance ScaleVanderbilt Therapeutic Alliance ScaleManual-guided therapiesTwelve-step facilitationObjective outcome measuresCalifornia Psychotherapy Alliance ScalesPredictive validityTherapeutic Alliance ScaleCognitive behavioral therapyWorking Alliance InventoryClinical trialsOutcome measuresAlliance instrumentsRating ScaleSubstance useTherapist-rated measureTherapeutic allianceAlliance InventoryTherapyOutcomes
2000
One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment
Carroll K, Nich C, Ball S, McCance E, Frankforter T, Rounsaville B. One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment. Addiction 2000, 95: 1335-1349. PMID: 11048353, DOI: 10.1046/j.1360-0443.2000.95913355.x.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentTwelve-step facilitationInitiation of abstinenceAlcohol useSubstance abuse treatment centersFrequency of cocaineAlcohol-dependent individualsClinical managementMain effectBrief treatmentEfficacy of disulfiramUrine toxicology screenCessation of treatmentBreathalyzer testEnd of treatmentOutcomes 1 yearAbstinencePercentage of daysEffect of treatmentCocaineLong-term benefitsToxicology screenTreatment centersBetter outcomesBrief periodA general system for evaluating therapist adherence and competence in psychotherapy research in the addictions
Carroll K, Nich C, Sifry R, Nuro K, Frankforter T, Ball S, Fenton L, Rounsaville B. A general system for evaluating therapist adherence and competence in psychotherapy research in the addictions. Drug And Alcohol Dependence 2000, 57: 225-238. PMID: 10661673, DOI: 10.1016/s0376-8716(99)00049-6.Peer-Reviewed Original ResearchConceptsTherapist adherenceRandomized clinical trialsSubstance use disordersDrug abuse treatmentYale AdherenceClinical trialsPharmacotherapy researchUse disordersBehavioral treatmentAbuse treatmentClinical researchAdherenceTreatmentComparison treatmentCompetence scoresExcellent reliabilityAddictionDiscriminant validityCompetence ScaleFactor structurePsychotherapy research
1995
Integrating psychotherapy and pharmacotherapy for cocaine dependence: results from a randomized clinical trial.
Carroll KM, Rounsaville BJ, Nich C, Gordon L, Gawin F. Integrating psychotherapy and pharmacotherapy for cocaine dependence: results from a randomized clinical trial. NIDA Research Monograph 1995, 150: 19-35. PMID: 8742770.Peer-Reviewed Original Research
1994
Blind Man’s Bluff: Effectiveness and Significance of Psychotherapy and Pharmacotherapy Blinding Procedures in a Clinical Trial
Carroll K, Rounsaville B, Nich C. Blind Man’s Bluff: Effectiveness and Significance of Psychotherapy and Pharmacotherapy Blinding Procedures in a Clinical Trial. Journal Of Consulting And Clinical Psychology 1994, 62: 276-280. PMID: 8201064, DOI: 10.1037/0022-006x.62.2.276.Peer-Reviewed Original ResearchPsychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers
Carroll KM, Rounsaville BJ, Gordon LT, Nich C, Jatlow P, Bisighini RM, Gawin FH. Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers. JAMA Psychiatry 1994, 51: 177-187. PMID: 8122955, DOI: 10.1001/archpsyc.1994.03950030013002.Peer-Reviewed Original ResearchConceptsClinical managementCocaine useCocaine abusersRelapse preventionAmbulatory cocaine abusersWeeks of treatmentForm of treatmentHigh-severity patientsInitiation trialsAbstinence initiationBaseline severityClinical trialsEffective treatmentTreatment retentionBetter outcomesCocaine abusePharmacotherapyDepressed subjectsPlaceboDesipramine hydrochlorideSpecialized treatmentDesipraminePreventionGreater reductionDistinct subgroups