2012
Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial
Carroll KM, Nich C, Shi JM, Eagan D, Ball SA. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial. Drug And Alcohol Dependence 2012, 126: 224-231. PMID: 22695473, PMCID: PMC3461119, DOI: 10.1016/j.drugalcdep.2012.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcohol DrinkingCocaine-Related DisordersCounselingDemographyDiagnostic and Statistical Manual of Mental DisordersDisulfiramDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMethadoneNarcoticsOpiate Substitution TreatmentPatient ComplianceRegression AnalysisSelf-Help GroupsSocioeconomic FactorsSubstance Abuse DetectionTreatment OutcomeConceptsMethadone maintenance programEfficacy of disulfiramAlcohol use disorderCocaine useStandard counselingUse disordersCommunity-based methadone maintenance programRandomized placebo-controlled trialPlacebo-controlled trialCurrent alcohol use disorderTwelve-step facilitationCocaine-negative urinesLess cocaine useMethadone maintenanceStep FacilitationCocaine-dependent individualsPlaceboBetter outcomesDisulfiram efficacyTreatment approachesFactorial trialDisulfiramMaintenance programRelative efficacyCocaine users
2002
‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data
Nich C, Carroll KM. ‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data. Drug And Alcohol Dependence 2002, 68: 121-130. PMID: 12234641, PMCID: PMC3651592, DOI: 10.1016/s0376-8716(02)00111-4.Peer-Reviewed Original ResearchConceptsEffectiveness of treatmentTreat analysisClinical trialsRandomized clinical trialsClinical trial dataStudy treatmentProtocol violationsTreat strategyTreatment retentionPoint of dropoutTime-varying covariatesTrial dataCocaine dependenceIntended durationParticipant dropoutRelative efficacyTrialsTreatmentMultiple analytic strategiesRetention outcomesDurationFull durationStrategy 1Analytic strategiesSubstantial levels