2018
Accounting for the uncounted: Physical and affective distress in individuals dropping out of oral naltrexone treatment for opioid use disorder
Carroll KM, Nich C, Frankforter TL, Yip SW, Kiluk BD, DeVito EE, Sofuoglu M. Accounting for the uncounted: Physical and affective distress in individuals dropping out of oral naltrexone treatment for opioid use disorder. Drug And Alcohol Dependence 2018, 192: 264-270. PMID: 30300800, PMCID: PMC6203294, DOI: 10.1016/j.drugalcdep.2018.08.019.Peer-Reviewed Original ResearchConceptsOpioid use disorderOral naltrexoneUse disordersAffective symptomsVoucher-based contingency managementDysphoric symptomsAffective distressOral naltrexone treatmentMultiple baseline characteristicsBaseline characteristicsNaltrexone treatmentHigh riskNaltrexoneSomatic symptomsSymptomsContingency managementTreatmentHigh rateDistressSubstantial evidenceTrialsTheoretical benefitsDisordersAffective discomfortParticipants
2007
The Impact of Personality Disorders on Alcohol‐Use Outcomes in a Pharmacotherapy Trial for Alcohol Dependence and Comorbid Axis I Disorders
Ralevski E, Ball S, Nich C, Limoncelli D, Petrakis I. The Impact of Personality Disorders on Alcohol‐Use Outcomes in a Pharmacotherapy Trial for Alcohol Dependence and Comorbid Axis I Disorders. American Journal On Addictions 2007, 16: 443-449. PMID: 18058408, DOI: 10.1080/10550490701643336.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcoholismAntisocial Personality DisorderBehavior, AddictiveBorderline Personality DisorderComorbidityDiagnostic and Statistical Manual of Mental DisordersDisulfiramFemaleHumansMaleMental DisordersMiddle AgedNaltrexoneNarcotic AntagonistsPatient CompliancePersonality DisordersPlacebosPsychiatric Status Rating ScalesTreatment OutcomeConceptsBorderline personality disorderAxis I DisordersAlcohol dependenceAlcohol use outcomesPersonality disorderI disordersAxis IComorbid Axis I disordersContext of pharmacotherapyAxis II disordersMajor Axis IMedication trialsPharmacotherapy trialsPoor responseOutcome measuresPatientsNaltrexoneAlcohol useDiagnosisUse outcomesDiagnosis of antisocialDisordersDisulfiramOutcomesASPD
2006
Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Post-Traumatic Stress Disorder
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Ralevski E, Rounsaville B. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Post-Traumatic Stress Disorder. Biological Psychiatry 2006, 60: 777-783. PMID: 17008146, DOI: 10.1016/j.biopsych.2006.03.074.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderAlcohol dependencePsychiatric symptomsComorbid post-traumatic stress disorderVeterans Administration Outpatient ClinicStress disorderAxis I psychiatric disordersBetter alcohol outcomesDouble-blind randomizationOverall psychiatric symptomsDSM-IV criteriaTreatment of alcoholismOpen randomizationActive medicationAdverse eventsAlcohol use outcomesOutpatient clinicGGT levelsMedication studiesPsychiatric disordersSide effectsNaltrexoneAlcohol cravingDrug AdministrationPlacebo
2005
Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, Group V. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders. Biological Psychiatry 2005, 57: 1128-1137. PMID: 15866552, DOI: 10.1016/j.biopsych.2005.02.016.Peer-Reviewed Original ResearchConceptsPsychiatric disordersAlcohol dependenceVeterans Administration Outpatient ClinicAxis I psychiatric disordersComorbid psychiatric disordersUse of disulfiramTreatment of alcoholismEvent Monitoring SystemAlcohol-dependent individualsActive medicationAdverse eventsSecondary outcomesPrimary outcomeMedication complianceOutpatient clinicSignificant group differencesGGT levelsMedication studiesPsychiatric symptomsAlcohol consumptionNaltrexoneAlcohol cravingDrug AdministrationConsecutive weeksPlacebo
2004
Millon Clinical Multiaxial Inventory-III Subtypes of Opioid Dependence: Validity and Matching to Behavioral Therapies
Ball SA, Nich C, Rounsaville BJ, Eagan D, Carroll KM. Millon Clinical Multiaxial Inventory-III Subtypes of Opioid Dependence: Validity and Matching to Behavioral Therapies. Journal Of Consulting And Clinical Psychology 2004, 72: 698-711. PMID: 15301655, PMCID: PMC3709250, DOI: 10.1037/0022-006x.72.4.698.Peer-Reviewed Original ResearchConceptsLess symptom improvementOpioid-dependent outpatientsOpioid dependenceSymptom improvementClinical trialsBetter outcomesPredictive validity analysesBehavioral therapyVoucher conditionSubtypesAffective disturbancesIntervention conditionMatching AnalysisPredictive validityCounselingValidity analysisNaltrexoneGroup counselingOutpatientsTherapyTrials
2002
Contingency Management to Enhance Naltrexone Treatment of Opioid Dependence: A Randomized Clinical Trial of Reinforcement Magnitude
Carroll KM, Sinha R, Nich C, Babuscio T, Rounsaville BJ. Contingency Management to Enhance Naltrexone Treatment of Opioid Dependence: A Randomized Clinical Trial of Reinforcement Magnitude. Experimental And Clinical Psychopharmacology 2002, 10: 54-63. PMID: 11866252, DOI: 10.1037/1064-1297.10.1.54.Peer-Reviewed Original ResearchConceptsNaltrexone treatmentContingency managementOpioid-dependent individualsSignificant reductionReinforcement magnitudeOpioid useAvailable pharmacotherapiesNaltrexone maintenanceOpioid dependenceClinical trialsCM groupBehavioral therapyNaltrexoneTreatmentCM conditionRelative benefitsParticipantsPharmacotherapyTherapyTrialsWeeks