2022
Precision medicine requires understanding how both sex and gender influence health
Stachenfeld NS, Mazure CM. Precision medicine requires understanding how both sex and gender influence health. Cell 2022, 185: 1619-1622. PMID: 35561661, DOI: 10.1016/j.cell.2022.04.012.Peer-Reviewed Original Research
2019
Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers
Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAmphetamineDopamineFemaleHumansMalePositron-Emission TomographyPrefrontal CortexReceptors, Dopamine D2Sex CharacteristicsSmokersConceptsDA releasePositron emission tomographyD2R availabilityDorsolateral prefrontal cortexMale smokersFemale smokersTobacco smokingPrefrontal cortexAmphetamine-induced DA releaseAmphetamine-induced dopamine releaseCortical DA releaseMesocortical DA systemEffects of nicotineSmoking-related behaviorsMesolimbic dopamine systemLong-term abstinenceSex differencesGender-specific treatmentFemale nonsmokersTobacco smokersAmphetamine administrationDopamine releaseNeurochemical mechanismsNonsmokersSmokersThe Influence of Sex and Gender on Health: How Much Is Being Taught in Medical School Curricula?
Thande NK, Wang M, Curlin K, Dalvie N, Mazure CM. The Influence of Sex and Gender on Health: How Much Is Being Taught in Medical School Curricula? Journal Of Women's Health 2019, 28: 1748-1754. PMID: 30864888, DOI: 10.1089/jwh.2018.7229.Peer-Reviewed Original ResearchThe federal plan for health science and technology’s response to the opioid crisis: understanding sex and gender differences as part of the solution is overlooked
Becker JB, Mazure CM. The federal plan for health science and technology’s response to the opioid crisis: understanding sex and gender differences as part of the solution is overlooked. Biology Of Sex Differences 2019, 10: 3. PMID: 30616693, PMCID: PMC6322277, DOI: 10.1186/s13293-018-0215-5.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidFederal GovernmentFemaleHealth PolicyHumansMaleOpioid-Related DisordersSex CharacteristicsUnited StatesConceptsOpioid crisisClinical care providersCurrent opioid epidemicNeurobiology of painGender-specific treatmentGender differencesNeonatal exposureOpioid useOpioid epidemicOpioid addictionCare providersEpidemiological dataPrevention strategiesHealth SciencesGender-based treatmentSuccessful responseSexPrevention implicationsReportTreatmentAddictionFurther researchResponseOpioidsPain
2018
Gender differences in psychiatric and medical comorbidity with post-traumatic stress disorder
Husky MM, Mazure CM, Kovess-Masfety V. Gender differences in psychiatric and medical comorbidity with post-traumatic stress disorder. Comprehensive Psychiatry 2018, 84: 75-81. PMID: 29723769, DOI: 10.1016/j.comppsych.2018.04.007.Peer-Reviewed Original ResearchConceptsSevere post-traumatic stress disorderPost-traumatic stress disorderMedical conditionsPsychiatric disordersComposite International Diagnostic Interview Short FormStress disorderComorbid psychiatric disordersCross-sectional general population surveySubstance use disordersGender-specific differencesGeneral population surveyMedical comorbiditiesMedical morbiditySevere headacheComorbid depressionSocietal burdenGeneral populationSevere casesUse disordersGreater oddsGender differencesNeck problemsPTSD diagnosisPTSD sufferersAnxiety disorders
2016
Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents
Lippard ET, Mazure CM, Johnston JA, Spencer L, Weathers J, Pittman B, Wang F, Blumberg HP. Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents. Journal Of Neuroscience Research 2016, 95: 777-791. PMID: 27870392, PMCID: PMC5123602, DOI: 10.1002/jnr.23901.Peer-Reviewed Original ResearchConceptsGray matter volumePrefrontal gray matter volumeBipolar disorderSubstance use problemsFuture substance useSubstance useLower gray matter volumeUse problemsFuture substance use problemsRegional gray matter volumeStructural magnetic resonanceAdverse outcomesTemporopolar cortexInsula gray matter volumeSubstance exposureMood disordersHigh riskLower riskSubsequent alcoholMatter volumeNeurodevelopmental basisSubstance problemsDisordersAdolescentsMalesBalance of the Sexes: Addressing Sex Differences in Preclinical Research.
Zakiniaeiz Y, Cosgrove KP, Potenza MN, Mazure CM. Balance of the Sexes: Addressing Sex Differences in Preclinical Research. The Yale Journal Of Biology And Medicine 2016, 89: 255-9. PMID: 27354851, PMCID: PMC4918870.Peer-Reviewed Original Research
2013
Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: Duration of use and gender difference
Ide JS, Zhang S, Hu S, Sinha R, Mazure CM, Li CS. Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: Duration of use and gender difference. Drug And Alcohol Dependence 2013, 134: 51-62. PMID: 24090712, PMCID: PMC3865077, DOI: 10.1016/j.drugalcdep.2013.09.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCerebral CortexCocaine-Related DisordersEcho-Planar ImagingFemaleHumansMaleMiddle AgedSex CharacteristicsTime FactorsYoung AdultConceptsGray matter volumeSuperior frontal gyrusDuration of useGM volumeMatter volumeLow-frequency fluctuationsBOLD signalCingulate cortexCD individualsCocaine useCerebral gray matter volumeAlcohol useMiddle/posterior cingulate cortexRight superior frontal gyrusGM volume lossBilateral superior frontal gyrusHealthy control subjectsRight ventral putamenMagnetic resonance imagingChronic cocaine usePosterior cingulate cortexInfluence of ageEffect of ageControl subjectsVentral putamenError processing and gender-shared and -specific neural predictors of relapse in cocaine dependence
Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM, Hong KI, Sinha R, Mazure CM, Li CS. Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 2013, 136: 1231-1244. PMID: 23485852, PMCID: PMC3613717, DOI: 10.1093/brain/awt040.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexFunctional magnetic resonance imagingCognitive controlError-related activationError processingCocaine-dependent individualsAnterior cingulate cortexSignal taskCingulate cortexCocaine dependenceFunctional magnetic resonance imaging (fMRI) dataStop-signal taskTreatment-seeking individualsCross-sectional findingsModerate-sized cohortsBrain activationBehavioral treatmentNeural predictorsDrug useMagnetic resonance imaging dataStatistical Parametric Mapping 8Regional activationPsychosocial factorsSuccess trialsMagnetic resonance imaging
2012
Sex Differences in Availability of β2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco Smokers
Cosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR, O’Malley S. Sex Differences in Availability of β2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco Smokers. JAMA Psychiatry 2012, 69: 418-427. PMID: 22474108, PMCID: PMC3508698, DOI: 10.1001/archgenpsychiatry.2011.1465.Peer-Reviewed Original ResearchMeSH KeywordsAdultAzetidinesBehavior, AddictiveBrainDepressionEstradiolFemaleFunctional NeuroimagingHumansIodine RadioisotopesMaleNicotinic AntagonistsProgesteronePyridinesRadioligand AssayReceptors, NicotinicSex CharacteristicsSmokingSubstance Withdrawal SyndromeTomography, Emission-Computed, Single-PhotonConceptsNAChR availabilityFemale smokersTobacco smokersNicotinic acetylcholine receptorsFemale nonsmokersProgesterone levelsAcetylcholine receptorsFemale sex steroid hormonesSex differencesSex steroid hormone levelsAbstinent tobacco smokersSex-matched nonsmokersTobacco smoking effectsMagnetic resonance imaging studyAge-matched malesEquilibrium distribution volumeEffects of nicotineSex steroid hormonesSteroid hormone levelsUnderlying neurochemical mechanismsResonance imaging studySingle photon emissionDays of abstinenceIA SPECTNicotine therapy
2010
Exploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch
Epperson CN, Toll B, Wu R, Amin Z, Czarkowski KA, Jatlow P, Mazure CM, O’Malley S. Exploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch. Drug And Alcohol Dependence 2010, 112: 1-8. PMID: 20561758, PMCID: PMC2946976, DOI: 10.1016/j.drugalcdep.2010.04.021.Peer-Reviewed Original ResearchConceptsPlacebo groupStudy completersNaltrexone doseClinical trialsContinuous abstinenceOral naltrexone treatmentNicotine patch therapyNicotine replacement therapyInteractive voice responseRandomized clinical trialsMenstrual cycle statusEffect of doseNaltrexone augmentationNaltrexone groupAdverse eventsNaltrexone treatmentNicotine patchPatch therapyReplacement therapyQuit dayWeek 1AbstinenceDoseWomenLess adherent
2009
Gender Differences in Associations between Lifetime Alcohol, Depression, Panic Disorder, and Posttraumatic Stress Disorder and Tobacco Withdrawal
Weinberger AH, Maciejewski PK, McKee SA, Reutenauer EL, Mazure CM. Gender Differences in Associations between Lifetime Alcohol, Depression, Panic Disorder, and Posttraumatic Stress Disorder and Tobacco Withdrawal. American Journal On Addictions 2009, 18: 140-147. PMID: 19283566, PMCID: PMC2874459, DOI: 10.1080/10550490802544888.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceAbuse/dependenceMajor depressionWithdrawal symptomsPsychiatric statusSmoking relapsePanic disorderIndices of withdrawalStrong associationSmoking cessation interventionNational Comorbidity SurveyPosttraumatic stress disorderGender-specific effectsCessation interventionsNicotine withdrawalTobacco withdrawalRetrospective dataStress disorderLifetime alcoholLonger durationDepressionWithdrawalDisordersRelapseMultiple regression analysis
2007
Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men
Hyman SM, Paliwal P, Chaplin TM, Mazure CM, Rounsaville BJ, Sinha R. Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men. Drug And Alcohol Dependence 2007, 92: 208-216. PMID: 17900822, PMCID: PMC2233653, DOI: 10.1016/j.drugalcdep.2007.08.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAdult Survivors of Child AbuseChildChild Abuse, SexualCocaine-Related DisordersData Interpretation, StatisticalFemaleFollow-Up StudiesHumansInpatientsMaleMiddle AgedPredictive Value of TestsProspective StudiesPsychiatric Status Rating ScalesRecurrenceSex CharacteristicsSocioeconomic FactorsSubstance Abuse Treatment CentersSurveys and QuestionnairesConceptsOverall childhood traumaCocaine relapse outcomesChildhood traumaEmotional abuseRelapse outcomesChildhood emotional abuseCocaine treatment outcomesCocaine-dependent menCocaine-dependent adultsCocaine relapseAssociation of severityRisk of relapseSexual abusePhysical abuseGender-specific effectsInitial relapseDay cocaineCocaine dependenceDependent adultsInpatient SampleInpatient treatmentTreatment outcomesGreater severityAbuseDependent menEvolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry
Cosgrove KP, Mazure CM, Staley JK. Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry. Biological Psychiatry 2007, 62: 847-855. PMID: 17544382, PMCID: PMC2711771, DOI: 10.1016/j.biopsych.2007.03.001.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain ChemistryFemaleGonadal Steroid HormonesHumansMaleMenstrual CycleReceptors, SerotoninSerotoninSex CharacteristicsConceptsMagnetic resonance imagingFunctional magnetic resonance imagingPositron emission tomographyBrain structuresPsychiatric disordersHealthy individualsFemale brainResonance imagingSex differencesGlobal cerebral blood flowRegional volume differencesCerebral blood flowDevastating brain disorderStructural magnetic resonance imagingSex-specific treatmentsGamma-aminobutyric acidEnglish-language literatureSingle photon emissionEpidemiologic evidencePathophysiological mechanismsHealthy menHigh percentageMEDLINE searchSex-specific differencesBlood flow
2001
Gender Differences in Referral to Cardiac Rehabilitation Programs after Revascularization
Caulin-Glaser T, Blum M, Schmeizl R, Prigerson H, Zaret B, Mazure C. Gender Differences in Referral to Cardiac Rehabilitation Programs after Revascularization. Journal Of Cardiopulmonary Rehabilitation And Prevention 2001, 21: 24-30. PMID: 11271654, DOI: 10.1097/00008483-200101000-00006.Peer-Reviewed Original ResearchConceptsCoronary revascularization proceduresCoronary bypass surgeryRevascularization proceduresSecondary preventionCR programPrevention instructionCardiac rehabilitation referralCases-observational studyInstruction of patientsCardiac rehabilitation programSecondary prevention strategiesBypass surgeryCardiac rehabilitationCoronary stentingRehabilitation referralPatient populationPhysician referralCardiovascular diseaseObservational studyRehabilitation programPrevention strategiesGender differencesHealthcare providersReferralDecreased likelihood