2003
Discontinuation of Antidepressants in Newly Admitted Psychotic Patients
Bowers MB, McKay BG, Mazure CM. Discontinuation of Antidepressants in Newly Admitted Psychotic Patients. Journal Of Neuropsychiatry 2003, 15: 227-230. PMID: 12724466, DOI: 10.1176/jnp.15.2.227.Peer-Reviewed Original Research
1999
Olanzapine for Treatment-Refractory Psychosis in Patients Responsive to, but Intolerant of, Clozapine
Weiss E, Longhurst J, Bowers M, Mazure C. Olanzapine for Treatment-Refractory Psychosis in Patients Responsive to, but Intolerant of, Clozapine. Journal Of Clinical Psychopharmacology 1999, 19: 378-380.. PMID: 10440469, DOI: 10.1097/00004714-199908000-00017.Peer-Reviewed Original Research
1998
Acute Neuroleptic Treatment in Elderly Patients Without Dementia
Mazure C, Nelson J, Jatlow P, Bowers M. Acute Neuroleptic Treatment in Elderly Patients Without Dementia. American Journal Of Geriatric Psychiatry 1998, 6: 221-229. PMID: 9659955, DOI: 10.1097/00019442-199800630-00005.Peer-Reviewed Original ResearchConceptsNon-elderly adultsElderly patientsNeuroleptic treatmentAcute responseLow dosesLow-dose neuroleptic treatmentAcute neuroleptic treatmentAdverse effectsHigh-dose treatmentLow-dose treatmentDrug blood levelsPrimary psychotic illnessInitial doseBlood levelsPsychotic illnessEffective treatmentPatientsDose ratioLonger durationTreatmentLower ratesDosesAdultsResponseNeuroleptics
1997
Recent life stressors and biological markers in newly admitted psychotic patients
Mazure C, Quinlan D, Bowers M. Recent life stressors and biological markers in newly admitted psychotic patients. Biological Psychiatry 1997, 41: 865-870. PMID: 9099413, DOI: 10.1016/s0006-3223(96)00222-3.Peer-Reviewed Original Research
1995
Developmental and Biologic Correlates of Early Neuroleptic Response
Bowers M, Mazure C, Glick M, Zigler E. Developmental and Biologic Correlates of Early Neuroleptic Response. Journal Of Clinical Psychopharmacology 1995, 15: 224-225.. PMID: 7636003, DOI: 10.1097/00004714-199506000-00014.Peer-Reviewed Original ResearchAssessment of extrapyramidal symptoms during acute neuroleptic treatment.
Mazure CM, Cellar JS, Bowers MB, Nelson JC, Takeshita J, Zigun B. Assessment of extrapyramidal symptoms during acute neuroleptic treatment. The Journal Of Clinical Psychiatry 1995, 56: 94-100. PMID: 7883736.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAkathisia, Drug-InducedAntipsychotic AgentsBasal Ganglia DiseasesDystoniaFemaleHumansMaleMiddle AgedParkinson Disease, SecondaryPhysical ExaminationPsychiatric Status Rating ScalesPsychotic DisordersReproducibility of ResultsSeverity of Illness IndexStatistics, NonparametricConceptsExtrapyramidal symptomsDrug regimenAcute treatmentNeuroleptic drugsSide effectsInterrater reliabilityAcute neuroleptic treatmentPatient's drug regimenExtrapyramidal Symptoms ScaleExtrapyramidal side effectsTraditional neuroleptic drugsLow nonsignificant correlationsRatings of symptomsAcute administrationNeuroleptic treatmentAdverse reactionsParkinson's diseasePsychotic symptomsSymptom ScalePsychotic patientsEPS scaleSymptomsClinician ratersCliniciansInterrater agreementDSM-III-R Axis IV: Clinician Reliability and Comparability to Patients’ Reports of Stressor Severity
Mazure CM, Kincare P, Schaffer CE. DSM-III-R Axis IV: Clinician Reliability and Comparability to Patients’ Reports of Stressor Severity. Psychiatry 1995, 58: 56-64. PMID: 7792323, DOI: 10.1080/00332747.1995.11024711.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAgedBipolar DisorderDementiaDepressive DisorderFemaleHumansMaleMiddle AgedPatient AdmissionPersonality AssessmentPsychiatric Status Rating ScalesPsychometricsPsychotic DisordersReproducibility of ResultsRisk FactorsSchizophreniaSchizophrenic PsychologySomatoform DisordersStress, PsychologicalConceptsPsychosocial stressorsAxis IVClinical setting todayMultiaxial diagnostic systemImportant precipitantsExacerbation of psychopathologyPatient reportsPatients' appraisalPsychiatric disordersClinical ratingsClinician reliabilityObjective ratingsSeverityExacerbationStressor severityNosological systemsReportStressorsSubjective appraisalClinicians
1992
Lithium in combination with perphenazine: effect on plasma monoamine metabolites
Bowers M, Mazure C, Nelson J, Jatlow P. Lithium in combination with perphenazine: effect on plasma monoamine metabolites. Biological Psychiatry 1992, 32: 1102-1107. PMID: 1477190, DOI: 10.1016/0006-3223(92)90190-b.Peer-Reviewed Original ResearchValproate Treatment of Older Psychotic Patients with Organic Mental Syndromes and Behavioral Dyscontrol
Mazure CM, Druss BG, Cellar JS. Valproate Treatment of Older Psychotic Patients with Organic Mental Syndromes and Behavioral Dyscontrol. Journal Of The American Geriatrics Society 1992, 40: 914-916. PMID: 1512389, DOI: 10.1111/j.1532-5415.1992.tb01990.x.Peer-Reviewed Original ResearchDrug-responsive symptoms during early neuroleptic treatment
Mazure C, Nelson J, Jatlow P, Bowers M. Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Research 1992, 41: 147-154. PMID: 1574541, DOI: 10.1016/0165-1781(92)90106-d.Peer-Reviewed Original ResearchConceptsDrug responseEarly drug responseDays of treatmentIdentification of symptomsNeuroleptic treatmentSerum concentrationsNeuroleptic drugsNeurochemical mechanismsPositive symptomsSymptomsProgressive phaseDrug actionConceptual disorganizationMultiple regression analysisRegression analysisTreatmentPsychosisSeverityHallucinationsResponse
1991
Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis
Mazure C, Nelson J, Jatlow P, Bowers M. Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis. Biological Psychiatry 1991, 30: 475-482. PMID: 1932395, DOI: 10.1016/0006-3223(91)90309-a.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultBipolar DisorderChromatography, High Pressure LiquidDepressive DisorderDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolMiddle AgedPerphenazinePrognosisProspective StudiesPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsPlasma homovanillic acidHomovanillic acidFree homovanillic acidClinical responseEarly clinical responsePlasma-free homovanillic acidUseful clinical predictorClinical predictorsNeuroleptic treatmentAcute psychosisDopamine metabolismNoradrenergic functioningMethoxyhydroxyphenylglycolFavorable responsePsychotic inpatientsGood responseSignificant decline
1990
The relationship between blood perphenazine levels, early resolution of psychotic symptoms, and side effects.
Mazure CM, Nelson JC, Jatlow PI, Kincare P, Bowers MB. The relationship between blood perphenazine levels, early resolution of psychotic symptoms, and side effects. The Journal Of Clinical Psychiatry 1990, 51: 330-4. PMID: 2199431.Peer-Reviewed Original ResearchMeSH KeywordsAdultAkathisia, Drug-InducedBasal Ganglia DiseasesBenztropineClinical Trials as TopicDose-Response Relationship, DrugDrug Administration ScheduleFemaleHospitalizationHumansMaleParkinson Disease, SecondaryPerphenazinePsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsExtrapyramidal side effectsSide effectsBrief Psychiatric Rating Scale (BPRS) totalSerious extrapyramidal side effectsIndividual BPRS itemsResolution of psychosisEarly resolutionBlood level monitoringBlood levelsIndividual symptomsTherapeutic thresholdPsychotic symptomsPsychotic inpatientsScale totalDrug efficacyBPRS itemsPerphenazine concentrationSymptomsPsychosisPerphenazineLevel monitoringPsychotogenic Drug Use and Neuroleptic Response
Bowers MB, Mazure CM, Nelson JC, Jatlow PI. Psychotogenic Drug Use and Neuroleptic Response. Schizophrenia Bulletin 1990, 16: 81-85. PMID: 1970670, DOI: 10.1093/schbul/16.1.81.Peer-Reviewed Original ResearchConceptsDrug useNeuroleptic responseDual diagnosis patientsDoses of haloperidolPsychotic malesDevelopment of psychosisPsychotogenic drugsDiagnosis patientsDopaminergic mechanismsPrior historyPsychotic disordersMeans of effectsRefractorinessSeparate studiesMalesEarly stagesHaloperidolPatientsIllnessPsychosisDoses