2023
Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlaceboCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchMeSH KeywordsAdultBinge-Eating DisorderBulimiaCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedObesityProspective StudiesTreatment OutcomeConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapyPsychiatric comorbidity as a prospective predictor of long-term weight and psychosocial outcomes after bariatric surgery
Ivezaj V, Dilip A, Grilo C. Psychiatric comorbidity as a prospective predictor of long-term weight and psychosocial outcomes after bariatric surgery. General Hospital Psychiatry 2023, 83: 51-58. PMID: 37099869, DOI: 10.1016/j.genhosppsych.2023.03.005.Peer-Reviewed Original ResearchMeSH KeywordsAdultBariatric SurgeryComorbidityFeeding and Eating DisordersHumansObesity, MorbidProspective StudiesWeight LossConceptsEating Disorder Examination-Bariatric Surgery VersionLong-term weight outcomesPost-bariatric surgeryPsychiatric comorbidityEating-disorder psychopathologyBariatric surgeryWeight outcomesMonths post-bariatric surgeryMini International Neuropsychiatric InterviewWeight loss outcomesCurrent psychiatric disorderCurrent psychiatric comorbidityInternational Neuropsychiatric InterviewPsychosocial functioning outcomesLong-term weightBeck Depression InventoryPoor psychosocial functioningPrognostic significanceProspective studyBariatric populationNeuropsychiatric InterviewClinical significanceComorbiditiesLoss outcomesPsychiatric disorders
2017
Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight
Chao AM, Jastreboff AM, White MA, Grilo CM, Sinha R. Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight. Obesity 2017, 25: 713-720. PMID: 28349668, PMCID: PMC5373497, DOI: 10.1002/oby.21790.Peer-Reviewed Original ResearchConceptsFuture weight gainAppetite-related hormonesFood cravingsChronic stressWeight gainProspective community cohortFood Craving InventoryTotal ghrelinCommunity cohortBlood drawMorning cortisolClinical covariatesHormone levelsBody weightCortisol responseHigher food cravingsHigher cortisolCortisolCumulative Adversity InterviewCravingLinear mixed modelsBaselineGhrelinHormoneMonths
2016
Children of parents with BED have more eating behavior disturbance than children of parents with obesity or healthy weight
Lydecker JA, Grilo CM. Children of parents with BED have more eating behavior disturbance than children of parents with obesity or healthy weight. International Journal Of Eating Disorders 2016, 50: 648-656. PMID: 27859458, PMCID: PMC5429220, DOI: 10.1002/eat.22648.Peer-Reviewed Original ResearchConceptsBinge-eating disorderChild weightChildren's bingeEating-disorder psychopathologyHigher child weightCross-sectional findingsChild overweightProspective confirmationChildren's eatingChild feedingChild overeatingDietary restrictionObesityClinical interventionsPrevention effortsEating Disorder BehaviorsDisordersBingePreliminary evidencePotential factorsEatingCurrent studyLimited literatureCore featuresOB
2015
Prognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study
White MA, Kalarchian MA, Levine MD, Masheb RM, Marcus MD, Grilo CM. Prognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study. Obesity Surgery 2015, 25: 1909-1916. PMID: 25720515, PMCID: PMC4551611, DOI: 10.1007/s11695-015-1631-9.Peer-Reviewed Original ResearchConceptsGastric bypass surgeryPostoperative depressive symptomsElevated depressive symptomsDepressive symptomsBypass surgeryWeight outcomesPrognostic significanceDisorder psychopathologyLong-term weight outcomesWeight lossPoorer weight outcomesPreoperative depressive symptomsBariatric surgery patientsWeight loss outcomesSignificant depressive symptomsMethodsThree hundred fiftyQuality of lifeBeck Depression InventorySurgery patientsBattery of assessmentsHundred fiftyLoss outcomesBackgroundThis studySurgeryClinical attention
2014
Prospective Association Between Overvaluation of Weight and Binge Eating Among Overweight Adolescent Girls
Sonneville KR, Grilo CM, Richmond TK, Thurston IB, Jernigan M, Gianini L, Field AE. Prospective Association Between Overvaluation of Weight and Binge Eating Among Overweight Adolescent Girls. Journal Of Adolescent Health 2014, 56: 25-29. PMID: 25438968, PMCID: PMC4275318, DOI: 10.1016/j.jadohealth.2014.08.017.Peer-Reviewed Original ResearchConceptsOverweight adolescent girlsSevere depressive symptomsWeekly bingeOverweight girlsOvervaluation of weightGreater impairmentDepressive symptomsProspective associationsAdolescent girlsCross-sectional analysisSubjective social statusObese girlsSignificant associationBinge eatingGreater riskTime 2BingeLow subjective social statusImpairmentToday StudyTime 1SymptomsGirlsAssociationWeight overvaluationInteractions of borderline personality disorder and mood disorders over 10 years.
Gunderson JG, Stout RL, Shea MT, Grilo CM, Markowitz JC, Morey LC, Sanislow C, Yen S, Zanarini MC, Keuroghlian AS, McGlashan TH, Skodol AE. Interactions of borderline personality disorder and mood disorders over 10 years. The Journal Of Clinical Psychiatry 2014, 75: 829-34. PMID: 25007118, DOI: 10.4088/jcp.13m08972.Peer-Reviewed Original ResearchConceptsMajor depressive disorderBorderline personality disorderMood disordersBipolar disorderPersonality disorderIndependent disorderProportional hazards regression analysisTreatment of BPDCo-occurring major depressive disorderHazards regression analysisCollaborative Longitudinal Personality DisordersDepressive disorderAppropriate treatmentBPD patientsRemissionDisordersRegression analysisTreatmentReciprocal interactionsMDD interactionsYearsPatientsWorseningEffect of improvement
2013
Convergent and Incremental Predictive Validity of Clinician, Self-Report, and Structured Interview Diagnoses for Personality Disorders Over 5 Years
Samuel DB, Sanislow CA, Hopwood CJ, Shea MT, Skodol AE, Morey LC, Ansell EB, Markowitz JC, Zanarini MC, Grilo CM. Convergent and Incremental Predictive Validity of Clinician, Self-Report, and Structured Interview Diagnoses for Personality Disorders Over 5 Years. Journal Of Consulting And Clinical Psychology 2013, 81: 650-659. PMID: 23647282, PMCID: PMC4030440, DOI: 10.1037/a0032813.Peer-Reviewed Original ResearchConceptsPD diagnosisSelf-report questionnairesPsychosocial functioningStructured diagnostic instrumentsPredictive validityCollaborative Longitudinal Personality Disorders StudyDiagnostic methodsStructured interview diagnosesPersonality disorder diagnosisSemistructured interview methodPersonality Disorders StudyClinical contactInterview diagnosesLinear regression analysisDiagnostic InterviewClinician ratingsDiagnosisDisorder diagnosisPersonality disorderTherapist ratingsDisorders StudyIncremental predictive validityHierarchical linear regression analysesRegression analysisSemistructured interviews
2012
Interpersonal Pathoplasticity in the Course of Major Depression
Cain NM, Ansell EB, Wright AG, Hopwood CJ, Thomas KM, Pinto A, Markowitz JC, Sanislow CA, Zanarini MC, Shea MT, Morey LC, McGlashan TH, Skodol AE, Grilo CM. Interpersonal Pathoplasticity in the Course of Major Depression. Journal Of Consulting And Clinical Psychology 2012, 80: 78-86. PMID: 22103955, PMCID: PMC3265649, DOI: 10.1037/a0026433.Peer-Reviewed Original Research
2011
Stressful life events predict eating disorder relapse following remission: Six‐year prospective outcomes
Grilo CM, Pagano ME, Stout RL, Markowitz JC, Ansell EB, Pinto A, Zanarini MC, Yen S, Skodol AE. Stressful life events predict eating disorder relapse following remission: Six‐year prospective outcomes. International Journal Of Eating Disorders 2011, 45: 185-192. PMID: 21448971, PMCID: PMC3275672, DOI: 10.1002/eat.20909.Peer-Reviewed Original ResearchConceptsStressful life eventsPersonality disorder statusBulimia nervosaLife eventsNegative stressful life eventsSignificant warning signsED relapseSignificant predictorsComorbid psychiatric disordersStructured Clinical InterviewSocial stressorsAssessment interviewsSocial stressDiagnostic InterviewClinical InterviewDisorder relapsePersonality disorderED durationLongitudinal intervalDSM-IVStructured interviewsEDNOSPsychiatric comorbidityPsychiatric disordersElevated work
2010
Personality disorders predict relapse after remission from an episode of major depressive disorder: a 6-year prospective study.
Grilo CM, Stout RL, Markowitz JC, Sanislow CA, Ansell EB, Skodol AE, Bender DS, Pinto A, Shea MT, Yen S, Gunderson JG, Morey LC, Hopwood CJ, McGlashan TH. Personality disorders predict relapse after remission from an episode of major depressive disorder: a 6-year prospective study. The Journal Of Clinical Psychiatry 2010, 71: 1629-35. PMID: 20584514, PMCID: PMC4615714, DOI: 10.4088/jcp.08m04200gre.Peer-Reviewed Original ResearchMeSH KeywordsAdultBorderline Personality DisorderComorbidityDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedObsessive-Compulsive DisorderPersonality DisordersPrognosisProspective StudiesRegression AnalysisSecondary PreventionSeverity of Illness IndexConceptsEpisode of MDDMajor depressive disorderDepressive disorderPersonality disorderSurvival analysisDSM-IV-diagnosed major depressive disorderProportional hazards regression analysisCourse of MDDAxis I psychiatric disordersHazards regression analysisLongitudinal Interval FollowNegative prognostic predictorPersonality disorder comorbidityLife table survival analysisStructured Clinical InterviewDSM-IV personality disordersCollaborative Longitudinal Personality Disorders StudyInterval FollowPrognostic predictorProspective studyDysthymic disorderBaseline enrollmentDisorder comorbidityPersonality Disorders StudyRemissionEthnicity in trauma and psychiatric disorders: findings from the collaborative longitudinal study of personality disorders
Benítez C, Yen S, Shea MT, Edelen MO, Markowitz JC, McGlashan TH, Ansell EB, Grilo CM, Skodol AE, Gunderson JG, Morey LC. Ethnicity in trauma and psychiatric disorders: findings from the collaborative longitudinal study of personality disorders. Journal Of Clinical Psychology 2010, 66: 583-598. PMID: 20455250, PMCID: PMC3719974, DOI: 10.1002/jclp.20686.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesPsychiatric disordersAfrican AmericansHigh ratePersonality disorderMajor depressive disorderCollaborative Longitudinal Personality Disorders StudyCollaborative longitudinal studyBorderline personality disorderLifetime traumatic eventsAdverse childhood experiencesAdverse eventsDepressive disorderPersonality Disorders StudyInjury/Mental disordersStudy aimSubstance useDisordersDisorders StudySerious injuriesEthnic differencesLongitudinal studySimilar traumaPosttraumatic stress
2009
Loss of control over eating predicts outcomes in bariatric surgery patients: a prospective, 24-month follow-up study.
White MA, Kalarchian MA, Masheb RM, Marcus MD, Grilo CM. Loss of control over eating predicts outcomes in bariatric surgery patients: a prospective, 24-month follow-up study. The Journal Of Clinical Psychiatry 2009, 71: 175-84. PMID: 19852902, PMCID: PMC2831110, DOI: 10.4088/jcp.08m04328blu.Peer-Reviewed Original ResearchConceptsBariatric surgery patientsSurgery patientsQuality of lifeGastric bypass surgery patientsDisorder psychopathologyWeight lossPostsurgical weight lossBypass surgery patientsWeight loss outcomesNegative prognostic indicatorBariatric surgeryPostoperative outcomesPostsurgical outcomesPrognostic indicatorBattery of assessmentsClinical significancePostsurgical improvementLoss outcomesMixed model analysisClinical attentionPatientsSurgeryPostsurgeryDepression levelsPsychosocial outcomesTen-Year Stability and Latent Structure of the DSM–IV Schizotypal, Borderline, Avoidant, and Obsessive-Compulsive Personality Disorders
Sanislow CA, Little TD, Ansell EB, Grilo CM, Daversa M, Markowitz JC, Pinto A, Shea MT, Yen S, Skodol AE, Morey LC, Gunderson JG, Zanarini MC, McGlashan TH. Ten-Year Stability and Latent Structure of the DSM–IV Schizotypal, Borderline, Avoidant, and Obsessive-Compulsive Personality Disorders. Journal Of Psychopathology And Clinical Science 2009, 118: 507-519. PMID: 19685948, PMCID: PMC6445274, DOI: 10.1037/a0016478.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBorderline Personality DisorderCohort StudiesCompulsive Personality DisorderDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleHumansLongitudinal StudiesMaleMiddle AgedModels, PsychologicalPersonality DisordersProspective StudiesPsychometricsReproducibility of ResultsSchizotypal Personality DisorderSex FactorsYoung AdultConceptsPersonality disorderTime pointsCross-sectional studyTen-year stabilityObsessive-compulsive personality disorderCollaborative Longitudinal Personality DisordersMental disordersObsessive-compulsive PDPD diagnosisStatistical ManualMean levelsDisordersAvoidant PDImpending revisionInitial time pointPrior factor analytic studiesSemistructured interviewsDiagnostic constructsSchizotypalAnalytic studyLongitudinal modelFactor analytic studiesDiagnosisPathology
2007
Rapid Response Predicts Treatment Outcomes in Binge Eating Disorder: Implications for Stepped Care
Masheb RM, Grilo CM. Rapid Response Predicts Treatment Outcomes in Binge Eating Disorder: Implications for Stepped Care. Journal Of Consulting And Clinical Psychology 2007, 75: 639-644. PMID: 17663617, DOI: 10.1037/0022-006x.75.4.639.Peer-Reviewed Original ResearchConceptsWeight lossCare treatment modelMost patient characteristicsRandomized clinical trialsDifferent prognostic significanceSelf-help treatmentBinge Eating DisorderBinge remissionOverweight patientsPatient characteristicsPrognostic significanceStepped careTreatment weekClinical trialsTreatment outcomesDepressive symptomsDepressive symptomatologyCBTgshEating DisordersBingeTreatment modelGreater reductionTreatment effectsGreater improvementDisorders
2006
The prognostic significance of regular binge eating in extremely obese gastric bypass patients: 12-month postoperative outcomes.
White MA, Masheb RM, Rothschild BS, Burke-Martindale CH, Grilo CM. The prognostic significance of regular binge eating in extremely obese gastric bypass patients: 12-month postoperative outcomes. The Journal Of Clinical Psychiatry 2006, 67: 1928-35. PMID: 17194271, DOI: 10.4088/jcp.v67n1213.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody ImageBulimiaDepressionFemaleGastric BypassHumansMaleMiddle AgedObesityPrognosisProspective StudiesSelf ConceptTreatment OutcomeConceptsNon-binge eatersRegular bingeBinge eatersObese gastric bypass patientsAssessment of bingeBinge-eating groupBinge-eating statusObese bariatric surgery candidatesRobust improvementBariatric surgery candidatesBody dissatisfactionInfrequent bingePsychosocial functioningPreoperative bingePsychological problemsPsychosocial problemsBingeEatersMonths postsurgerySurgery candidatesEatingGastric bypass surgery patientsPostoperative outcomesPrognostic significanceSharp improvement
2001
Different Methods for Assessing the Features of Eating Disorders in Patients with Binge Eating Disorder: A Replication
Grilo C, Masheb R, Wilson G. Different Methods for Assessing the Features of Eating Disorders in Patients with Binge Eating Disorder: A Replication. Obesity 2001, 9: 418-422. PMID: 11445665, DOI: 10.1038/oby.2001.55.Peer-Reviewed Original Research