2024
Treatment of Eating Disorders: Current Status, Challenges, and Future Directions
Grilo C. Treatment of Eating Disorders: Current Status, Challenges, and Future Directions. Annual Review Of Clinical Psychology 2024, 20: 97-123. PMID: 38211625, DOI: 10.1146/annurev-clinpsy-080822-043256.Peer-Reviewed Original ResearchAnorexia nervosaBinge-eating disorderBulimia nervosaEating disordersAdaptive treatment designsPsychological treatmentTreatment researchNervosaTreatment designDisordersBulimiaPharmacological optionsAnorexiaEnhanced outcomesExpected final online publication dateFirst-line approachOnline publication dateMedicationFirst-lineClinical guidanceAnnual ReviewAlternative treatmentRevised estimatesPatientsTreatment
2023
Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Yurkow S, Ivezaj V, Grilo C. Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity. International Journal Of Eating Disorders 2023, 56: 2074-2083. PMID: 37530200, PMCID: PMC10834830, DOI: 10.1002/eat.24035.Peer-Reviewed Original ResearchConceptsCardiovascular disease risk factorsModest weight lossDisease risk factorsBinge-eating disorderPlasma glucoseRisk factorsWeight lossLifestyle changesBehavioral lifestyle changesCardiovascular disease riskWeight loss treatmentSignificant improvementRelated lifestyle changesTotal cholesterolPotential health benefitsHeart ratePatientsObesityDisease riskHbA1cHealth benefitsDisordersTriglyceridesTreatmentPosttreatmentCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapyPredictors and significance of rapid response to behaviorally based treatment of binge eating disorder
Yurkow S, Ivezaj V, Grilo C. Predictors and significance of rapid response to behaviorally based treatment of binge eating disorder. Obesity 2023, 31: 390-398. PMID: 36623872, PMCID: PMC9877118, DOI: 10.1002/oby.23648.Peer-Reviewed Original ResearchConceptsDemographic featuresTreatment attitudesWeight lossFourth treatment weekWeight loss outcomesPsychiatric variablesSuperior clinical outcomesWeight loss treatmentTreatment of bingeClinical severity variablesClinical outcomesPrognostic significanceTreatment weekClinical trialsBaseline predictorsLoss outcomesLoss treatmentPosttreatment outcomesBinge eatingIndependent assessorsBingeSeverity variablesDisordersPatientsTreatment
2022
Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy
Forrest L, Franko D, Thompson‐Brenner H, Grilo C. Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy. International Journal Of Eating Disorders 2022, 56: 944-955. PMID: 36565241, PMCID: PMC10159900, DOI: 10.1002/eat.23883.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive behavioral therapyEvidence-based treatmentsInterpersonal psychotherapyIntervention targetsBinge-eating disorder symptomsBehavioral therapyIndicator of remissionShape concernsRefinement of treatmentClinical utilityFrequent associationClinical implicationsSymptomsSymptom interactionsTherapyInterpersonal therapyWeight concernsDisorder symptomsSymptom relationshipsDisordersPatientsTreatmentSizeable minorityNetwork of symptoms
2018
Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change
Barnes RD, Ivezaj V, Pittman BP, Grilo CM. Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change. International Journal Of Eating Disorders 2018, 51: 558-564. PMID: 29637592, PMCID: PMC6002900, DOI: 10.1002/eat.22860.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentBinge-eating disorderLoss treatmentWeight lossBed statusWeight loss treatment outcomesOverweight/obesityWeight loss trialAverage weight lossWeight-related variablesPrognostic significancePrimary careTreatment outcomesTreatment responseLoss trialWeight trajectoriesTreatment studiesDisorder statusWeight changeOutcomesTreatmentIndividual responsesStatusPositive outcomes
2017
Back to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up
Barnes RD, Ivezaj V, Martino S, Pittman BP, Grilo CM. Back to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up. Obesity 2017, 25: 2074-2078. PMID: 29086484, PMCID: PMC5705439, DOI: 10.1002/oby.21972.Peer-Reviewed Original ResearchConceptsWeight loss interventionPrimary careBinge-eating disorderWeight lossNutrition psychoeducationLoss interventionSecondary end point analysisWeight loss 12 monthsAttention-controlled comparisonMotivational interviewingMIC patientsEnd-point analysisTreatment conclusionOne-yearBed statusSmall effect sizesCareMonthsPatientsInterventionEffect sizeTreatmentPsychoeducationLong-term impactMixed modelsEvaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers
White MA, Ivezaj V, Grilo CM. Evaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers. Journal Of Health Psychology 2017, 24: 1796-1806. PMID: 28810442, DOI: 10.1177/1359105317701560.Peer-Reviewed Original ResearchConceptsSmoking cessation treatmentCessation treatmentObese smokersCognitive-behavioral treatmentBehavioral treatmentCognitive-behavioral smoking cessation treatmentBehavioral smoking cessation treatmentNicotine replacement therapyOverweight/obesityCessation ratesReplacement therapyRegular smokersStandard treatmentHealth educationLarger studySmokersPerson assessmentPilot studyCommunity volunteersTreatmentLess weightKey outcomesParticipantsObesityTherapy
2016
Food Thought Suppression Inventory: Test–retest reliability and relationship to weight loss treatment outcomes
Barnes RD, Ivezaj V, Grilo CM. Food Thought Suppression Inventory: Test–retest reliability and relationship to weight loss treatment outcomes. Eating Behaviors 2016, 22: 93-95. PMID: 27112114, PMCID: PMC5161461, DOI: 10.1016/j.eatbeh.2016.04.001.Peer-Reviewed Original ResearchConceptsFood Thought Suppression InventoryWeight loss treatmentBinge-eating episodesTest-retest reliabilityLoss treatmentWeight loss treatment outcomesWeight lossWeight loss goalsOriginal body weightWeek test-retest reliabilityPercent weight lossPrimary careTreatment outcomesIntra-class correlationBody weightBaselineTreatmentScoresEpisodesParticipantsPost assessmentHigh levelsBingeRandomized controlled trial testing behavioral weight loss versus multi-modal stepped-care treatment for binge eating disorder
Grilo C. Randomized controlled trial testing behavioral weight loss versus multi-modal stepped-care treatment for binge eating disorder. European Psychiatry 2016, 33: s163. DOI: 10.1016/j.eurpsy.2016.01.321.Peer-Reviewed Original ResearchStepped-care treatmentAnti-obesity medicationsRemission rateWeight lossBehavioral weight lossCo-morbid obesityStepped-care modelObese BED patientsSignificant time effectInitial respondersTreatment challengesBED patientsMedicationsMixed model analysisPatientsBingePlaceboMonthsObesityBWLTreatmentStructured interviewsCBTDisordersMixed models
2014
Interactions of borderline personality disorder and mood disorders over 10 years.
Gunderson JG, Stout RL, Shea MT, Grilo CM, Markowitz JC, Morey LC, Sanislow C, Yen S, Zanarini MC, Keuroghlian AS, McGlashan TH, Skodol AE. Interactions of borderline personality disorder and mood disorders over 10 years. The Journal Of Clinical Psychiatry 2014, 75: 829-34. PMID: 25007118, DOI: 10.4088/jcp.13m08972.Peer-Reviewed Original ResearchConceptsMajor depressive disorderBorderline personality disorderMood disordersBipolar disorderPersonality disorderIndependent disorderProportional hazards regression analysisTreatment of BPDCo-occurring major depressive disorderHazards regression analysisCollaborative Longitudinal Personality DisordersDepressive disorderAppropriate treatmentBPD patientsRemissionDisordersRegression analysisTreatmentReciprocal interactionsMDD interactionsYearsPatientsWorseningEffect of improvement
2011
Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial
Grilo CM, Masheb RM, Wilson GT, Gueorguieva R, White MA. Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial. Journal Of Consulting And Clinical Psychology 2011, 79: 675-685. PMID: 21859185, PMCID: PMC3258572, DOI: 10.1037/a0025049.Peer-Reviewed Original ResearchConceptsPercent BMI lossBehavioral weight lossBinge-eating disorderCognitive behavioral therapyBMI lossObese patientsWeight lossBinge-eating remissionAlternative treatment optionBinge Eating DisorderRemission rateControlled TrialsTreatment optionsMixed model analysisBehavioral therapyPatientsManualized treatmentAssessment pointsBingeRemissionGreater reductionTreatmentTherapySequential treatmentDisordersA randomized controlled trial for obesity and binge eating disorder: Low-energy-density dietary counseling and cognitive-behavioral therapy
Masheb RM, Grilo CM, Rolls BJ. A randomized controlled trial for obesity and binge eating disorder: Low-energy-density dietary counseling and cognitive-behavioral therapy. Behaviour Research And Therapy 2011, 49: 821-829. PMID: 22005587, PMCID: PMC3223390, DOI: 10.1016/j.brat.2011.09.006.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyWeight lossDietary counselingVegetable consumptionPercent of participantsBinge remissionObese patientsRemission outcomesNutrition counselingMetabolic outcomesObese individualsConsecutive participantsFavorable outcomeDietary outcomesTwelve-monthBetter dietary outcomesDensity dietIndividual treatmentTreatment effectsOutcomesTherapyCounselingTreatmentBingeDisorders
2005
Eating patterns and breakfast consumption in obese patients with binge eating disorder
Masheb RM, Grilo CM. Eating patterns and breakfast consumption in obese patients with binge eating disorder. Behaviour Research And Therapy 2005, 44: 1545-1553. PMID: 16376851, DOI: 10.1016/j.brat.2005.10.013.Peer-Reviewed Original ResearchConceptsBreakfast consumptionWeight loss outcomesTreatment of BEDFrequency of mealsHalf of participantsObese patientsObese individualsImportant clinical applicationsLoss outcomesFrequent mealsSpecific interventionsBingeBreakfastClinical applicationDisorder featuresMealSelf-report measuresDaysDisordersTreatmentParticipantsSnacksSemi-structured interviewsPatientsA randomized controlled comparison of guided self-help cognitive behavioral therapy and behavioral weight loss for binge eating disorder
Grilo CM, Masheb RM. A randomized controlled comparison of guided self-help cognitive behavioral therapy and behavioral weight loss for binge eating disorder. Behaviour Research And Therapy 2005, 43: 1509-1525. PMID: 16159592, DOI: 10.1016/j.brat.2004.11.010.Peer-Reviewed Original ResearchConceptsSelf-help cognitive behavioral therapyCognitive behavioral therapyWeight lossConsecutive overweight patientsHigher remission ratesBehavioral weight lossTreatment of BEDOverweight patientsRemission rateTreat analysisMinimal therapist guidanceHigher completion ratesTherapist guidanceBehavioral therapyCBTgshControl treatment conditionsSelf-help approachTreatment treatmentNon-specific influencesRelative efficacyTreatmentCompletion ratesTherapyBingeDisordersTesting an APA Practice Guideline: SymptomTargeted Medication Utilization for Patients With Borderline Personality Disorder
Oldham J, Bender D, Skodol A, Dyck I, Sanislow C, Yen S, Grilo C, Shea M, Zanarini M, Gunderson J, McGlashan T. Testing an APA Practice Guideline: SymptomTargeted Medication Utilization for Patients With Borderline Personality Disorder. FOCUS The Journal Of Lifelong Learning In Psychiatry 2005, 3: 484-488. DOI: 10.1176/foc.3.3.484.Peer-Reviewed Original ResearchBorderline personality disorderMedication utilizationPractice guidelinesPersonality disorderAmerican Psychiatric Association's Practice GuidelineImpulsive-behavioral dyscontrolPsychotropic medication treatmentClasses of medicationsTreatment of patientsComorbid Axis I conditionsAPA practice guidelinesAxis I conditionsAnticonvulsant useMedication treatmentCognitive-perceptual symptomsFunctional impairmentMedication practicesBPD patientsPatientsBPD symptomsSymptomsAffective dysregulationDisordersFunctioning variablesTreatment
2000
Self-Help and Guided Self-Help Treatments for Bulimia Nervosa and Binge Eating Disorder
GRILO C. Self-Help and Guided Self-Help Treatments for Bulimia Nervosa and Binge Eating Disorder. Journal Of Psychiatric Practice 2000, 6: 18-26. PMID: 15990473, DOI: 10.1097/00131746-200001000-00003.Peer-Reviewed Original Research
1998
Pretreatment patient factors predicting attrition from a multicenter randomized controlled treatment study for panic disorder
Grilo C, Money R, Barlow D, Goddard A, Gorman J, Hofmann S, Papp L, Shear M, Woods S. Pretreatment patient factors predicting attrition from a multicenter randomized controlled treatment study for panic disorder. Comprehensive Psychiatry 1998, 39: 323-332. PMID: 9829138, DOI: 10.1016/s0010-440x(98)90043-8.Peer-Reviewed Original ResearchConceptsPanic disorderFinal multivariate regression analysisMultivariate regression analysisLower household incomeNegative treatment attitudesPatient factorsPsychiatric comorbidityClinical trialsStudy groupPretreatment factorsClinical practicePrior treatmentTreatment studiesTreatment attitudesPredictor analysisLower educationAgoraphobic avoidanceLife stressorsTrend levelDisordersPatientsRegression analysisTreatmentGreater ageSocial supportThe Assessment and Treatment of Binge Eating Disorder.
GRILO C. The Assessment and Treatment of Binge Eating Disorder. Journal Of Psychiatric Practice 1998, 4: 191. DOI: 10.1097/00131746-199807000-00002.Peer-Reviewed Original ResearchBehavioral weight control treatmentSignificant acute reductionDiscontinuation of medicationWeight control treatmentTreatment of bingeBehavioral weight controlPreliminary dataWeight control practicesBinge Eating DisorderAcute reductionPsychiatric morbidityRecurrent episodesNew diagnosisInterpersonal psychotherapyWeight controlBulimia nervosaDSM-IVInterpersonal therapyBingeDisorder categoriesWeight lossResearch criteriaEating DisordersTreatmentMultimodal assessment