1997
D1–D2 Interaction in Feedback Control of Midbrain Dopamine Neurons
Shi W, Smith P, Pun C, Millet B, Bunney B. D1–D2 Interaction in Feedback Control of Midbrain Dopamine Neurons. Journal Of Neuroscience 1997, 17: 7988-7994. PMID: 9315916, PMCID: PMC6793911, DOI: 10.1523/jneurosci.17-20-07988.1997.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA cellsDA autoreceptorsDA neuronsD1 agonistLow dosesDopamine D1-like receptorsD1 inhibitionD1 effectNigral DA cellsMidbrain DA neuronsD2 agonist quinpiroleD1-like receptorsDA receptor subtypesMidbrain dopamine neuronsOnly low dosesDA receptorsEndogenous DAAgonist quinpiroleD2 agonistIntranigral applicationDopamine neuronsReceptor subtypesRat preparationTarget neurons
1996
Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons
Shim S, Bunney B, Shi W. Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons. Neuropsychopharmacology 1996, 15: 437-441. PMID: 8914116, DOI: 10.1016/s0893-133x(96)00052-8.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDA neuronsPrefrontal cortexSubstantia nigraPFC lesionsBursting activityFiring rateActive DA cellsSN DA neuronsActive DA neuronsMidbrain dopamine neuronsSingle-unit recordingsMedial prefrontal cortexDA cellsDopamine neuronsTegmental areaLocal injectionIbotenic acidUnit recordingsLesionsSame lesionNeuronsRatsActivityCortex
1995
Psychiatric status after human fetal mesencephalic tissue transplantation in Parkinson's disease
Price L, Spencer D, Marek K, Robbins R, Leranth C, Farhi A, Naftolin F, Roth R, Bunney B, Hoffer P, Makuch R, Redmond D. Psychiatric status after human fetal mesencephalic tissue transplantation in Parkinson's disease. Biological Psychiatry 1995, 38: 498-505. PMID: 8562661, DOI: 10.1016/0006-3223(95)00129-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBrain Tissue TransplantationCaudate NucleusDepressive DisorderDopamineFemaleFetal Tissue TransplantationFollow-Up StudiesHumansMaleMesencephalonMiddle AgedNeurocognitive DisordersNeuropsychological TestsPanic DisorderParkinson DiseasePostoperative ComplicationsProspective StudiesConceptsParkinson's diseasePsychiatric statusHuman fetal mesencephalic tissueAdrenal medullary graftsAdrenal medullary transplantationFetal mesencephalic tissueSystematic psychiatric assessmentPerioperative sequelaeMesencephalic tissuePsychiatric sequelaeCaudate nucleusPsychiatric assessmentNeurobiological effectsBehavioral symptomsTissue transplantationDiseasePatientsTransplantationSequelaeSuch episodesEpisodesGroup effectsStatusDeliriumDiscrete episodesGeneral Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's Disease
Sass K, Buchanan C, Westerveld M, Marek K, Farhi A, Robbins R, Naftolin F, Vollmer T, Leranth C, Roth R, Price L, Bunney B, Elsworth J, Hoffer P, Redmond D, Spencer D. General Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's Disease. JAMA Neurology 1995, 52: 680-686. PMID: 7619024, DOI: 10.1001/archneur.1995.00540310050016.Peer-Reviewed Original ResearchConceptsCognitive abilitiesNonverbal cognitive abilityVerbal cognitive abilityInformation-processing speedVerbal memoryNeuropsychological profileTest batteryCognitive functionNormal cognitive functionCognitive dysfunctionRight caudate nucleusCaudate nucleusFactor analysisTissue transplantationParkinson's disease
1993
Cellular replacement of dopamine deficit in Parkinson's disease using human fetal mesencephalic tissue: preliminary results in four patients.
Redmond D, Robbins R, Naftolin F, Marek K, Vollmer T, Leranth C, Roth R, Price L, Gjedde A, Bunney B. Cellular replacement of dopamine deficit in Parkinson's disease using human fetal mesencephalic tissue: preliminary results in four patients. Proceedings Of The Association For Research In Nervous And Mental Disease 1993, 71: 325-59. PMID: 8417471.Peer-Reviewed Original Research
1992
Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease
Spencer D, Robbins R, Naftolin F, Marek K, Vollmer T, Leranth C, Roth R, Price L, Gjedde A, Bunney B, Sass K, Elsworth J, Kier E, Makuch R, Hoffer P, Redmond D. Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease. New England Journal Of Medicine 1992, 327: 1541-1548. PMID: 1435880, DOI: 10.1056/nejm199211263272201.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAntiparkinson AgentsCaudate NucleusCryopreservationCyclosporineDopamineFemaleFetal Tissue TransplantationHomovanillic AcidHumansMagnetic Resonance ImagingMaleMesencephalonMiddle AgedMotor ActivityParkinson DiseasePutamenStereotaxic TechniquesTomography, Emission-ComputedConceptsCase patientsParkinson's diseaseMesencephalic tissueCaudate nucleusHuman fetal ventral mesencephalic tissueFetal ventral mesencephalic tissueHuman fetal mesencephalic tissueContinued disease progressionFetal dopaminergic neuronsFetal mesencephalic tissueVentral mesencephalic tissueSevere Parkinson's diseaseOptimal drug therapySigns of parkinsonismMidbrain dopamine neuronsPositron emission tomographyMonths of evaluationAntiparkinsonian medicationUnilateral transplantationDrug holidayMore medicationsStriatonigral degenerationNeurologic functionDopaminergic neuronsDrug therapyRoles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons
Shi W, Bunney B. Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons. Journal Of Neuroscience 1992, 12: 2433-2438. PMID: 1318960, PMCID: PMC6575923, DOI: 10.1523/jneurosci.12-06-02433.1992.Peer-Reviewed Original ResearchConceptsDopamine-induced inhibitionEffects of neurotensinDopamine neuronsIntracellular cAMPAdenylate cyclaseAction of neurotensinRat midbrain slicesAction of dopamineVentral tegmental areaMidbrain dopamine neuronsIntracellular cAMP levelsMidbrain slicesSubstantia nigraTegmental areaDopamine cellsDopamine effectsSpontaneous activityModulatory effectsNeurotensinIsobutyl methylxanthineInhibitory effectNeuronsCAMP levelsProtein kinase CInhibition
1991
Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex?
Shi W, Bunney B. Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex? Synapse 1991, 9: 157-164. PMID: 1776128, DOI: 10.1002/syn.890090302.Peer-Reviewed Original ResearchConceptsEffects of neurotensinNeurotensin receptorsDopamine neuronsDopamine cellsCell activitySingle-unit recording techniquesFiring rateMidbrain dopamine neuron activityAction of neurotensinBasal firing rateDopamine receptor blockadeDopamine-induced inhibitionDopamine neuron activityMidbrain dopamine neuronsReceptor blockadeDepolarization inactivationExcitatory effectsNative neurotensinBrain slicesNeuron activityNeurotensinNeurotensin analoguesSame receptorRecording techniquesReceptorsMidbrain dopamine system electrophysiological functioning: A review and new hypothesis
Bunney B, Chiodo L, Grace A. Midbrain dopamine system electrophysiological functioning: A review and new hypothesis. Synapse 1991, 9: 79-94. PMID: 1821487, DOI: 10.1002/syn.890090202.Peer-Reviewed Original ResearchNeurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity
Shi W, Bunney B. Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity. Brain Research 1991, 543: 315-321. PMID: 1676331, DOI: 10.1016/0006-8993(91)90043-u.Peer-Reviewed Original ResearchConceptsDA cellsCell activityFiring rateDA cell activityInteraction of neurotensinGlutamate-induced excitationEffects of neurotensinMidbrain dopamine cell activityDopamine cell activityMidbrain dopamine neuronsSpecific D2 agonistMicroiontophoretic techniquesD2 agonistDopamine neuronsD2 receptorsDopamine effectsSpontaneous activityNeurotensinNT effectsLocal ejectionInhibitionSignificant changesCellsCell levelSame cells
1990
Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons
Shi W, Bunney B. Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons. Neuropharmacology 1990, 29: 1095-1097. PMID: 1982340, DOI: 10.1016/0028-3908(90)90119-c.Peer-Reviewed Original ResearchConceptsD2 agonistDA cellsSingle-unit recording techniquesMidbrain DA neuronsCentral DA systemsDopamine D2 agonistMidbrain dopamine neuronsSpecific D2 agonistDA neuronsIntracerebroventricular administrationDopamine neuronsSpontaneous activityDA systemInhibitory effectRecording techniquesAgonistsNeuronsBiochemical studiesCellsQuinpiroleNeurotensinRatsAdministrationUtilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs
Moghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsDopamine systemNigrostriatal dopamine systemEffects of clozapineRelease of dopamineRat. 2Mesocortical dopamine systemAcute administrationVivo microdialysisMesotelencephalic systemNucleus accumbensPrefrontal effectPrefrontal cortexClozapineExtracellular concentrationDopamineHaloperidolMicrodialysisDrugsSulpirideMesolimbicStriatumAccumbensCortex
1989
The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons
Esposito E, Bunney B. The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons. European Journal Of Pharmacology 1989, 162: 109-113. PMID: 2656273, DOI: 10.1016/0014-2999(89)90609-2.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaVentral tegmental areaActive DA neuronsSCH 23390Chronic treatmentDA neuronsDopamine neuronsDepolarization blockSpontaneous activityDA receptor blockadeAcute subcutaneous injectionGroups of ratsMidbrain dopamine neuronsChronic haloperidolReceptor blockadeChronic administrationPars compactaTegmental areaAntipsychotic drugsSubcutaneous injectionChronic experimentsMarked reductionNeuronsTreatmentHaloperidol
1988
Effects of Acute and Chronic Neuroleptic Treatment on the Activity of Mid brain Dopamine Neuronsa
BUNNEY B. Effects of Acute and Chronic Neuroleptic Treatment on the Activity of Mid brain Dopamine Neuronsa. Annals Of The New York Academy Of Sciences 1988, 537: 77-85. PMID: 2904786, DOI: 10.1111/j.1749-6632.1988.tb42097.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsDopamineElectrophysiologyHumansIn Vitro TechniquesMesencephalonNeuronsConceptsAD administrationDA releaseDA cell activityChronic neuroleptic treatmentMidbrain DA neuronsRelease of DAEffects of AcuteNeurological side effectsDA neuronsNeuroleptic treatmentAcute effectsNerve terminalsSpontaneous activitySide effectsCell activityMarked increaseAdministrationProjection areaPrimary effectReleaseAcuteMarked effectNeuronsActivityBiochemical techniquesIntracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine
Silva N, Bunney B. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European Journal Of Pharmacology 1988, 149: 307-315. PMID: 3409955, DOI: 10.1016/0014-2999(88)90661-9.Peer-Reviewed Original ResearchConceptsSensitive neuronsInput resistanceAdministration of DADA-sensitive neuronsSelective D2 antagonistPacemaker-like activityHigh input resistanceZona compactaDA actionD2 antagonistDopamine neuronsIntracellular recordingsFiring rateIntracellular studyNeuronsReversal potentialTissue slicesDopamineHyperpolarizationSulpirideAntagonistCompactaAdministration
1987
Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences
Chiodo L, Bunney B. Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences. Journal Of Neuroscience 1987, 7: 629-633. PMID: 2881987, PMCID: PMC6569064, DOI: 10.1523/jneurosci.07-03-00629.1987.Peer-Reviewed Original ResearchConceptsDepolarization-induced inactivationFiring rateDopaminergic neuronsDopamine receptor agonist apomorphineMonths' continuous treatmentAcute oral administrationBasal firing rateActive DA neuronsReceptor agonist apomorphineA10 dopaminergic neuronsActive dopamine neuronsClassical antipsychotic drugsDopamine-containing neuronsPresence of haloperidolHr of administrationLong-term treatmentMidbrain dopaminergic neuronsCholecystokinin receptor antagonistAge-matched controlsHaloperidol resultsA10 regionDA neuronsAcute administrationAgonist apomorphineNeuroleptic haloperidol
1985
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons
Chiodo L, Bunney B. Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. Journal Of Neuroscience 1985, 5: 2539-2544. PMID: 2863337, PMCID: PMC6565310, DOI: 10.1523/jneurosci.05-09-02539.1985.Peer-Reviewed Original ResearchConceptsDA neuronsClozapine administrationChronic treatmentDepolarization inactivationExtracellular single cell recording techniquesInhibitory neurotransmitter gamma-aminobutyric acidNeurotransmitter gamma-aminobutyric acidVentral tegmental area (VTA) dopamineSingle cell recording techniquesA10 DA neuronsVivo spontaneous activityMidbrain DA neuronsChloral hydrate anesthesiaCombination of drugsMidbrain dopamine neuronsGamma-aminobutyric acidDifferential effectsMechanism of actionAcute treatmentMicroiontophoretic applicationSubstantia nigraReceptor antagonistDA cellsDopamine neuronsSpontaneous activityFurther Studies on the Specificity of Proglumide as a Selective Cholecystokinin Antagonist in the Central Nervous Systema
BUNNEY B, CHIODO L, FREEMAN A. Further Studies on the Specificity of Proglumide as a Selective Cholecystokinin Antagonist in the Central Nervous Systema. Annals Of The New York Academy Of Sciences 1985, 448: 345-351. PMID: 2862828, DOI: 10.1111/j.1749-6632.1985.tb29929.x.Peer-Reviewed Original ResearchOpposing effects of striatonigral feedback pathways on midbrain dopamine cell activity
Grace A, Bunney B. Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Research 1985, 333: 271-284. PMID: 2986775, DOI: 10.1016/0006-8993(85)91581-1.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsDA cellsStriatal stimulationReticulata neuronsDA neuronsRebound depolarizationReversal potentialSubstantia nigra zona reticulata neuronsStriatonigral GABAergic pathwayMidbrain dopamine cell activityDopamine cell activitySame stimulation parametersChloride injectionChloride channel blockerChloride reversal potentialSimilar reversal potentialsSimilar time courseGABAergic pathwayGABAergic projectionsZona reticulataPostsynaptic potentialsSystemic injectionChannel blockersIntracellular recordingsStriatal cells
1984
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
Freeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.Peer-Reviewed Original ResearchConceptsDA neuronsNeuronal activityN-allylnormetazocineMidbrain dopamine neuronal activitySingle-unit recording techniquesSubstantia nigra zona compactaFiring rateA10 DA neuronsDopamine neuronal activitySigma receptor agonistsMidbrain dopamine neuronsBaseline firing rateEffects of phencyclidineWeak inhibitory actionExcitatory effectsZona compactaHaloperidol pretreatmentDopamine neuronsReceptor agonistBiphasic effectInhibitory actionNeuronsRecording techniquesPhencyclidineDrugs