1993
In vivo assessment of basal and drug‐induced dopamine release in cortical and subcortical regions of the anesthetized primate
Moghaddam B, Berridge C, Goldman‐Rakic P, Bunney B, Roth R. In vivo assessment of basal and drug‐induced dopamine release in cortical and subcortical regions of the anesthetized primate. Synapse 1993, 13: 215-222. PMID: 8497807, DOI: 10.1002/syn.890130304.Peer-Reviewed Original ResearchConceptsExtracellular dopamine levelsBasal extracellular dopamine levelsDopamine levelsPrefrontal cortexPremotor cortexDrug-induced dopamine releaseVivo assessmentExtracellular concentrationNonhuman primatesBasal extracellular concentrationsCaudate-putamen areaFeasibility of microdialysisCortex of primatesMedial prefrontal cortexDorsolateral prefrontal cortexCortical dopamineIntracerebral microdialysisIntravenous administrationNeurological illnessDopamine releaseSubcortical areasCortical areasDopamine projectionsDopamine systemSubcortical regions
1990
Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies
Moghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistVivo voltammetryExtracellular DA concentrationsMM GluDA outflowStriatal dopamineReceptor antagonistExtracellular dopamineRat striatumVivo dialysisMicrodialysis probeLocal applicationBasal levelsExtracellular concentrationPathophysiological conditionsVivo releaseDA concentrationDopamineL-glutamateField potentialsIonic changesSignificant increaseSelective microelectrodesDepressionStriatumAcute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study
Moghaddam B, Bunney B. Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study. Journal Of Neurochemistry 1990, 54: 1755-1760. PMID: 1969939, DOI: 10.1111/j.1471-4159.1990.tb01230.x.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexOutflow of dopamineRelease of dopamineNucleus accumbensAntipsychotic drugsPrefrontal cortexAcute effectsExtracellular levelsAtypical antipsychotic drug clozapineVivo microdialysis studyAtypical antipsychotic drugsEffects of sulpirideEffects of haloperidolAntipsychotic drug clozapineMicrodialysis studyVivo microdialysisDrug clozapineHaloperidolStriatumAccumbensCortexSulpirideExtracellular concentrationDopamineDrugsCharacterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum
Moghaddam B, Roth R, Bunney B. Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum. Neuroscience 1990, 36: 669-676. PMID: 2234405, DOI: 10.1016/0306-4522(90)90009-s.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexRat medial prefrontal cortexPrefrontal cortexCortical dopamineDopamine releaseChloral hydrate-anesthetized ratsBeta-carboline FG 7142Dopamine release processBasal releasePara-tyrosineVivo microdialysisDopamine levelsFG 7142Local perfusionExtracellular dopamineAlpha-methylExtracellular levelsFmol/StriatumPharmacological manipulationCortexBasal levelsMicrodialysisStimulation conditionsDopamineUtilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs
Moghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsDopamine systemNigrostriatal dopamine systemEffects of clozapineRelease of dopamineRat. 2Mesocortical dopamine systemAcute administrationVivo microdialysisMesotelencephalic systemNucleus accumbensPrefrontal effectPrefrontal cortexClozapineExtracellular concentrationDopamineHaloperidolMicrodialysisDrugsSulpirideMesolimbicStriatumAccumbensCortex
1989
Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine
Moghaddam B, Bunney B. Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine. Journal Of Neurochemistry 1989, 53: 652-654. PMID: 2568406, DOI: 10.1111/j.1471-4159.1989.tb07383.x.Peer-Reviewed Original ResearchConceptsPharmacological responsivenessNigrostriatal dopamine systemExtracellular dopamine levelsExtracellular fluidBasal outflowBasal releaseStriatal dopamineHigh calcium levelsVivo microdialysisIonic compositionDopamine levelsCalcium levelsDopamine systemPharmacological manipulationRinger's solutionPerfusionDopamineResponsivenessSolution altersAltersMicrodialysis