1993
Depolarization inactivation of dopamine neurons: Terminal release characteristics
Moghaddam B, Bunney B. Depolarization inactivation of dopamine neurons: Terminal release characteristics. Synapse 1993, 14: 195-200. PMID: 8105547, DOI: 10.1002/syn.890140302.Peer-Reviewed Original ResearchConceptsExtracellular dopamine levelsChronic haloperidol treatmentDopamine levelsHaloperidol treatmentExtracellular levelsPerfusion of tetrodotoxinExcitatory amino acidsStriatal extracellular levelsVehicle-treated animalsExtracellular glutamate levelsHaloperidol-treated animalsMedial forebrain bundleStriatal dopamine systemGroups of animalsExogenous antagonistsChronic haloperidolChronic treatmentDepolarization inactivationExcitatory actionBasal outflowDopamine neuronsGlutamate levelsImpulse flowForebrain bundleMicrodialysis technique
1990
Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies
Moghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistVivo voltammetryExtracellular DA concentrationsMM GluDA outflowStriatal dopamineReceptor antagonistExtracellular dopamineRat striatumVivo dialysisMicrodialysis probeLocal applicationBasal levelsExtracellular concentrationPathophysiological conditionsVivo releaseDA concentrationDopamineL-glutamateField potentialsIonic changesSignificant increaseSelective microelectrodesDepressionStriatumAcute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study
Moghaddam B, Bunney B. Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study. Journal Of Neurochemistry 1990, 54: 1755-1760. PMID: 1969939, DOI: 10.1111/j.1471-4159.1990.tb01230.x.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexOutflow of dopamineRelease of dopamineNucleus accumbensAntipsychotic drugsPrefrontal cortexAcute effectsExtracellular levelsAtypical antipsychotic drug clozapineVivo microdialysis studyAtypical antipsychotic drugsEffects of sulpirideEffects of haloperidolAntipsychotic drug clozapineMicrodialysis studyVivo microdialysisDrug clozapineHaloperidolStriatumAccumbensCortexSulpirideExtracellular concentrationDopamineDrugsCharacterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum
Moghaddam B, Roth R, Bunney B. Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum. Neuroscience 1990, 36: 669-676. PMID: 2234405, DOI: 10.1016/0306-4522(90)90009-s.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCarbolinesCorpus StriatumDialysisDopamineFrontal LobeMalePotassiumRatsRats, Inbred StrainsConceptsMedial prefrontal cortexRat medial prefrontal cortexPrefrontal cortexCortical dopamineDopamine releaseChloral hydrate-anesthetized ratsBeta-carboline FG 7142Dopamine release processBasal releasePara-tyrosineVivo microdialysisDopamine levelsFG 7142Local perfusionExtracellular dopamineAlpha-methylExtracellular levelsFmol/StriatumPharmacological manipulationCortexBasal levelsMicrodialysisStimulation conditionsDopamineUtilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs
Moghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsDopamine systemNigrostriatal dopamine systemEffects of clozapineRelease of dopamineRat. 2Mesocortical dopamine systemAcute administrationVivo microdialysisMesotelencephalic systemNucleus accumbensPrefrontal effectPrefrontal cortexClozapineExtracellular concentrationDopamineHaloperidolMicrodialysisDrugsSulpirideMesolimbicStriatumAccumbensCortex
1989
Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine
Moghaddam B, Bunney B. Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine. Journal Of Neurochemistry 1989, 53: 652-654. PMID: 2568406, DOI: 10.1111/j.1471-4159.1989.tb07383.x.Peer-Reviewed Original ResearchConceptsPharmacological responsivenessNigrostriatal dopamine systemExtracellular dopamine levelsExtracellular fluidBasal outflowBasal releaseStriatal dopamineHigh calcium levelsVivo microdialysisIonic compositionDopamine levelsCalcium levelsDopamine systemPharmacological manipulationRinger's solutionPerfusionDopamineResponsivenessSolution altersAltersMicrodialysis
1988
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
Bean A, Shepard P, Bunney B, Nestler E, Roth R. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology 1988, 34: 715-8. PMID: 2974120.Peer-Reviewed Original ResearchConceptsPertussis toxin injectionDopamine synthesisToxin injectionDopamine autoreceptorsRat striatumPertussis toxinAutoreceptor-mediated inhibitionDopamine agonist apomorphineG proteinsAgonist apomorphineUnilateral administrationControl ratsSystemic administrationStriatal tissueEffects of activationAutoreceptorsApomorphineStriatumRatsAdministrationInjectionToxinActivationStriataAgonists
1986
Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.
Grace A, Bunney B. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. Journal Of Pharmacology And Experimental Therapeutics 1986, 238: 1092-100. PMID: 3746660.Peer-Reviewed Original ResearchConceptsAdministration of haloperidolDopamine neuronsVivo intracellular recordingsDepolarization blockIntracellular recordingsNigral dopamine neuronsAdministration of neurolepticsActive dopamine neuronsSpontaneous spike activityDopamine agonist apomorphineAntipsychotic drug haloperidolSpontaneous electrophysiological activityMidbrain dopamine neuronsAcute administrationAgonist apomorphineSubstantia nigraControl ratsExcitatory driveDepolarization blockadeDrug haloperidolSpontaneous activitySpike activityFiring rateHaloperidolNeurons
1985
Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology
Grace A, Bunney B. Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology. Brain Research 1985, 333: 285-298. PMID: 3995296, DOI: 10.1016/0006-8993(85)91582-3.Peer-Reviewed Original ResearchConceptsDA cell firingDA cellsLow dosesInput resistanceDA agonistsReversal potentialStriatonigral pathwayCell firingCell firing rateElectrophysiological actionsApomorphine effectApomorphine administrationSlow depolarizationIntracellular recordingsIntravenous administrationDopamine cellsInhibitory inputsApomorphineStriatal cellsAction potentialsFiring rateAgonistsDosesCell dischargeCell electrophysiologyOpposing effects of striatonigral feedback pathways on midbrain dopamine cell activity
Grace A, Bunney B. Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Research 1985, 333: 271-284. PMID: 2986775, DOI: 10.1016/0006-8993(85)91581-1.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsDA cellsStriatal stimulationReticulata neuronsDA neuronsRebound depolarizationReversal potentialSubstantia nigra zona reticulata neuronsStriatonigral GABAergic pathwayMidbrain dopamine cell activityDopamine cell activitySame stimulation parametersChloride injectionChloride channel blockerChloride reversal potentialSimilar reversal potentialsSimilar time courseGABAergic pathwayGABAergic projectionsZona reticulataPostsynaptic potentialsSystemic injectionChannel blockersIntracellular recordingsStriatal cells
1980
Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways
Hommer D, Bunney B. Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways. Life Sciences 1980, 27: 377-386. PMID: 7412480, DOI: 10.1016/0024-3205(80)90185-x.Peer-Reviewed Original ResearchConceptsStriato-nigral pathwayDopaminergic neuronsReticulata neuronsInhibitory periodSingle-unit recording techniquesNon-dopaminergic neuronsNigro-striatal pathwaySciatic nerve stimulationRat substantia nigraDopaminergic neuron activitySensory stimuliInitial inhibitionStimulation-induced changesActivity of dopaminergicNigral neuronsNerve stimulationSubstantia nigraNeuron activityNeuronsRecording techniquesHaloperidolLesionsInhibitionStimulationPathwayAcute and chronic haloperidol treatment: effects on nigrostriatal dopaminergic system activity.
Bunney B, Skirboll L, Grace A. Acute and chronic haloperidol treatment: effects on nigrostriatal dopaminergic system activity. Advances In Biochemical Psychopharmacology 1980, 24: 267-73. PMID: 7405666.Peer-Reviewed Original Research
1978
d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway
Bunney B, Aghajanian G. d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives Of Pharmacology 1978, 304: 255-261. PMID: 714182, DOI: 10.1007/bf00507966.Peer-Reviewed Original ResearchConceptsDA cellsSubstantia nigraFeedback pathwaysCentral dopamine neuronsIntravenous d-amphetamineNon-convulsant dosesPicrotoxin-treated animalsKainic acid injectionRelease of GABAActivity of dopamineNon-lesioned animalsSingle-cell recordingsDA autoreceptorsDendrodendritic synapsesMicroiontophoretic techniquesAfferent terminalsDepressant effectUnlesioned animalsDopamine neuronsGABA antagonistsAnesthetized ratsD-amphetamineCaudate nucleusAcid injectionHigh doses
1976
The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique
Bunney B, Aghajanian G. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique. Brain Research 1976, 117: 423-435. PMID: 990939, DOI: 10.1016/0006-8993(76)90751-4.Peer-Reviewed Original Researchd-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway
Bunney B, Achajanian G. d-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway. Science 1976, 192: 391-393. PMID: 1257777, DOI: 10.1126/science.1257777.Peer-Reviewed Original ResearchConceptsD-amphetamineDepressant effectDopaminergic cell activityIntravenous d-amphetamineCentral dopaminergic neuronsStriato-nigral pathwayNeuronal feedback loopMicroiontophoretic applicationDopaminergic neuronsDopaminergic cellsCell activitySignificant slowingFeedback pathwaysPrevious dataCellsLesionsPathwayNeurons
1975
Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics.
Bunney B, Roth R, Aghajanian G. Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics. Psychopharmacology Communications 1975, 1: 349-58. PMID: 1224004.Peer-Reviewed Original ResearchConceptsEffects of molindoneCentral dopaminergic neuronal activityExtracellular single-unit recordingsLow intravenous dosesDopaminergic neuronal activityDA neuron activityMost antipsychotic drugsBaseline firing rateSingle-unit recordingsDA metabolismDA neuronsIntravenous dosesClassical neurolepticsDopaminergic neuronsOlfactory tubercleDA cellsAntipsychotic drugsD-amphetamineInduced depressionRat midbrainDopamine synthesisNeuronal activityUnit recordingsNeuron activityMolindone