1991
Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity
Shi W, Bunney B. Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity. Brain Research 1991, 543: 315-321. PMID: 1676331, DOI: 10.1016/0006-8993(91)90043-u.Peer-Reviewed Original ResearchConceptsDA cellsCell activityFiring rateDA cell activityInteraction of neurotensinGlutamate-induced excitationEffects of neurotensinMidbrain dopamine cell activityDopamine cell activityMidbrain dopamine neuronsSpecific D2 agonistMicroiontophoretic techniquesD2 agonistDopamine neuronsD2 receptorsDopamine effectsSpontaneous activityNeurotensinNT effectsLocal ejectionInhibitionSignificant changesCellsCell levelSame cells
1989
Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.
Sesack S, Bunney B. Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 1323-33. PMID: 2564893.Peer-Reviewed Original ResearchConceptsRat medial prefrontal cortexMedial prefrontal cortexGamma-aminobutyric acidD2-selective agonistsSelective agonistPrefrontal cortexPFC neuronsInhibitory effectSelective antagonistExtracellular single-unit recordingsD1-selective agonistsSingle-unit recordingsD1-selective antagonistD2-selective antagonistWeak antagonist activityMicroiontophoretic studyMicroiontophoretic techniquesSuperficial laminaeIontophoretic applicationLY171555Pharmacological characterizationInhibitory responsesMajority of cellsPharmacological characteristicsPharmacological profile
1978
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity
Bunney B, Grace A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sciences 1978, 23: 1715-1727. PMID: 31529, DOI: 10.1016/0024-3205(78)90471-x.Peer-Reviewed Original ResearchConceptsChronic haloperidol treatmentDA cellsHaloperidol treatmentControl animalsCell activityExtracellular single-unit recordingsDopaminergic cell activityDopaminergic neuronal activityNigral DA cellsNeurological side effectsDopamine cell activitySingle-unit recordingsFeedback pathwaysComparison of effectsDA neuronsTime-dependent mannerMicroiontophoretic techniquesClinical effectsKainic acidAntipsychotic drugsDepolarization blockCaudate nucleusNeuronal activitySide effectsUnit recordingsd-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway
Bunney B, Aghajanian G. d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives Of Pharmacology 1978, 304: 255-261. PMID: 714182, DOI: 10.1007/bf00507966.Peer-Reviewed Original ResearchConceptsDA cellsSubstantia nigraFeedback pathwaysCentral dopamine neuronsIntravenous d-amphetamineNon-convulsant dosesPicrotoxin-treated animalsKainic acid injectionRelease of GABAActivity of dopamineNon-lesioned animalsSingle-cell recordingsDA autoreceptorsDendrodendritic synapsesMicroiontophoretic techniquesAfferent terminalsDepressant effectUnlesioned animalsDopamine neuronsGABA antagonistsAnesthetized ratsD-amphetamineCaudate nucleusAcid injectionHigh doses
1977
Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies
Aghajanian G, Bunney B. Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives Of Pharmacology 1977, 297: 1-7. PMID: 193046, DOI: 10.1007/bf00508803.Peer-Reviewed Original ResearchConceptsDA neuronsDepressant effectDA agonist apomorphineWeak depressant actionSingle-cell recording studiesSingle-cell recordingsAgonist apomorphineDA agonistsMicroiontophoretic applicationMicroiontophoretic techniquesSubstantia nigraDepressant actionDopamine neuronsSingle dopamine neuronsPharmacological characterizationCatecholamine receptorsΒ-adrenoreceptorsCell recordingsCatecholamine agonistsRecording studiesNeuronsAutoreceptorsAntagonist trifluoperazineAgonistsSelective responsiveness
1976
Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques
Bunney B, Aghajanian G. Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques. Life Sciences 1976, 19: 1783-1792. PMID: 1004134, DOI: 10.1016/0024-3205(76)90087-4.Peer-Reviewed Original ResearchConceptsRat prefrontal cortexMicroiontophoretic techniquesLayer VLayers IIPrefrontal cortexUptake blockersInhibitory effectNE uptake blockerDA receptor blockerCortical layers IIDA uptake blockersReceptor blockersDA inhibitionNoradrenergic projectionsAccumbens nucleusPharmacological differentiationNorepinephrineCell activitySensitivity of cellsHistochemical evidenceBlockersCortexDopamineSensitive cellsSuperficial layers