5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine
Rasmusson A, Goldstein L, Deutch A, Bunney B, Roth R. 5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine. Synapse 1994, 18: 218-224. PMID: 7855734, DOI: 10.1002/syn.890180307.Peer-Reviewed Original ResearchConceptsDopamine utilizationMedial prefrontal cortexStress-induced changesClinical efficacyMedial prefrontal cortical dopamineMicrograms/Prefrontal cortexAnxiety disordersPrefrontal cortical dopamineFootshock-induced increaseObserved clinical efficacyDopamine terminal fieldsCortical dopamineFootshock stressExtracellular dopamineHuman anxiety disordersNucleus accumbensSame doseTerminal fieldsEx vivo brain tissueNeurochemical analysisDopamine systemDPATAgonistsBrain tissueThe NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat
Goldstein L, Rasmusson A, Bunney B, Roth R. The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat. Journal Of Neuroscience 1994, 14: 4937-4950. PMID: 8046462, PMCID: PMC6577203, DOI: 10.1523/jneurosci.14-08-04937.1994.Peer-Reviewed Original ResearchConceptsStress-induced increaseNMDA glycine-site antagonistsDA utilizationGlycine modulatory siteGlycine site antagonistHA-966Conditioned stressPrefrontal cortexCortical dopamineSite antagonistNucleus accumbensControl animalsModulatory siteMedial prefrontal cortical dopamineLateral prefrontal cortexPrefrontal cortical dopamineSerum corticosterone levelsNMDA receptor complexPost-traumatic stress disorderMedial prefrontal cortexNeurotransmitter ratiosRegional dopamineSerotonin utilizationSerum corticosteroneNMDA receptors