1999
Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine
Zheng P, Zhang X, Bunney B, Shi W. Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 1999, 91: 527-535. PMID: 10366010, DOI: 10.1016/s0306-4522(98)00604-6.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsBenzazepinesDizocilpine MaleateDopamineDopamine AgonistsDopamine AntagonistsDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsIn Vitro TechniquesMaleMembrane PotentialsPrefrontal CortexPyramidal CellsQuinoxalinesQuinpiroleRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateConceptsN-methyl-D-aspartate functionN-methyl-D-aspartate currentsN-methyl-D-aspartate (NMDA) receptor-mediated transmissionN-methyl-D-aspartate receptor-mediated responsesN-methyl-D-aspartate receptorsHigh concentrations dopamineReceptor-mediated transmissionD2 agonist quinpiroleD1 agonist SKF38393D-aspartate antagonistD1-like receptorsGlutamate-mediated neurotransmissionD2-like receptorsPresence of tetrodotoxinEffects of dopamineReceptor-mediated responsesWhole-cell recordingsD-aspartate agonistMedial prefrontal cortexBrief local applicationDizocilpine maleateAgonist SKF38393Concentration of dopamineCortical dopamineGlutamate transmission
1996
Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons
Shim S, Bunney B, Shi W. Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons. Neuropsychopharmacology 1996, 15: 437-441. PMID: 8914116, DOI: 10.1016/s0893-133x(96)00052-8.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDA neuronsPrefrontal cortexSubstantia nigraPFC lesionsBursting activityFiring rateActive DA cellsSN DA neuronsActive DA neuronsMidbrain dopamine neuronsSingle-unit recordingsMedial prefrontal cortexDA cellsDopamine neuronsTegmental areaLocal injectionIbotenic acidUnit recordingsLesionsSame lesionNeuronsRatsActivityCortex
1994
5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine
Rasmusson A, Goldstein L, Deutch A, Bunney B, Roth R. 5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine. Synapse 1994, 18: 218-224. PMID: 7855734, DOI: 10.1002/syn.890180307.Peer-Reviewed Original ResearchConceptsDopamine utilizationMedial prefrontal cortexStress-induced changesClinical efficacyMedial prefrontal cortical dopamineMicrograms/Prefrontal cortexAnxiety disordersPrefrontal cortical dopamineFootshock-induced increaseObserved clinical efficacyDopamine terminal fieldsCortical dopamineFootshock stressExtracellular dopamineHuman anxiety disordersNucleus accumbensSame doseTerminal fieldsEx vivo brain tissueNeurochemical analysisDopamine systemDPATAgonistsBrain tissueThe NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat
Goldstein L, Rasmusson A, Bunney B, Roth R. The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat. Journal Of Neuroscience 1994, 14: 4937-4950. PMID: 8046462, PMCID: PMC6577203, DOI: 10.1523/jneurosci.14-08-04937.1994.Peer-Reviewed Original ResearchConceptsStress-induced increaseNMDA glycine-site antagonistsDA utilizationGlycine modulatory siteGlycine site antagonistHA-966Conditioned stressPrefrontal cortexCortical dopamineSite antagonistNucleus accumbensControl animalsModulatory siteMedial prefrontal cortical dopamineLateral prefrontal cortexPrefrontal cortical dopamineSerum corticosterone levelsNMDA receptor complexPost-traumatic stress disorderMedial prefrontal cortexNeurotransmitter ratiosRegional dopamineSerotonin utilizationSerum corticosteroneNMDA receptorsPreferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment
Youngren K, Moghaddam B, Bunney B, Roth R. Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. Neuroscience Letters 1994, 165: 41-44. PMID: 8015734, DOI: 10.1016/0304-3940(94)90704-8.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexChronic treatmentNucleus accumbensPrefrontal cortexChronic clozapine treatmentBasal dopamine releaseExtracellular dopamine levelsChronic clozapineClozapine treatmentIntracerebral microdialysisAcute doseDopaminergic toneDopamine levelsDopamine releaseExtracellular dopamineRat striatumDopamine overflowClozapineBrain regionsPreferential activationStriatumAccumbensCortexTreatmentMicrodialysis
1993
In vivo assessment of basal and drug‐induced dopamine release in cortical and subcortical regions of the anesthetized primate
Moghaddam B, Berridge C, Goldman‐Rakic P, Bunney B, Roth R. In vivo assessment of basal and drug‐induced dopamine release in cortical and subcortical regions of the anesthetized primate. Synapse 1993, 13: 215-222. PMID: 8497807, DOI: 10.1002/syn.890130304.Peer-Reviewed Original ResearchConceptsExtracellular dopamine levelsBasal extracellular dopamine levelsDopamine levelsPrefrontal cortexPremotor cortexDrug-induced dopamine releaseVivo assessmentExtracellular concentrationNonhuman primatesBasal extracellular concentrationsCaudate-putamen areaFeasibility of microdialysisCortex of primatesMedial prefrontal cortexDorsolateral prefrontal cortexCortical dopamineIntracerebral microdialysisIntravenous administrationNeurological illnessDopamine releaseSubcortical areasCortical areasDopamine projectionsDopamine systemSubcortical regions
1990
Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study
Moghaddam B, Bunney B. Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study. Journal Of Neurochemistry 1990, 54: 1755-1760. PMID: 1969939, DOI: 10.1111/j.1471-4159.1990.tb01230.x.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexOutflow of dopamineRelease of dopamineNucleus accumbensAntipsychotic drugsPrefrontal cortexAcute effectsExtracellular levelsAtypical antipsychotic drug clozapineVivo microdialysis studyAtypical antipsychotic drugsEffects of sulpirideEffects of haloperidolAntipsychotic drug clozapineMicrodialysis studyVivo microdialysisDrug clozapineHaloperidolStriatumAccumbensCortexSulpirideExtracellular concentrationDopamineDrugsCharacterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum
Moghaddam B, Roth R, Bunney B. Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum. Neuroscience 1990, 36: 669-676. PMID: 2234405, DOI: 10.1016/0306-4522(90)90009-s.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexRat medial prefrontal cortexPrefrontal cortexCortical dopamineDopamine releaseChloral hydrate-anesthetized ratsBeta-carboline FG 7142Dopamine release processBasal releasePara-tyrosineVivo microdialysisDopamine levelsFG 7142Local perfusionExtracellular dopamineAlpha-methylExtracellular levelsFmol/StriatumPharmacological manipulationCortexBasal levelsMicrodialysisStimulation conditionsDopamine
1989
Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin
Sesack S, Deutch A, Roth R, Bunney B. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin. The Journal Of Comparative Neurology 1989, 290: 213-242. PMID: 2592611, DOI: 10.1002/cne.902900205.Peer-Reviewed Original ResearchConceptsEfferent projectionsPhaseolus vulgaris leucoagglutininTopographical organizationInjection sitePrelimbic areaAnterograde tract‐tracing studyBasal forebrain nucleiAnterior olfactory nucleusLaterodorsal tegmental nucleusMesencephalic trigeminal nucleusIntralaminar thalamic nucleiMedullary reticular formationTract-tracing studiesDeep mesencephalic nucleusPeriaqueductal gray regionCytoarchitectonic divisionsCentral gray areaMedial prefrontal cortexVentral midbrain tegmentumOlfactory nucleusRaphe nucleusPrelimbic divisionLateral hypothalamusMesencephalic nucleusTrigeminal nucleusPharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.
Sesack S, Bunney B. Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 1323-33. PMID: 2564893.Peer-Reviewed Original ResearchConceptsRat medial prefrontal cortexMedial prefrontal cortexGamma-aminobutyric acidD2-selective agonistsSelective agonistPrefrontal cortexPFC neuronsInhibitory effectSelective antagonistExtracellular single-unit recordingsD1-selective agonistsSingle-unit recordingsD1-selective antagonistD2-selective antagonistWeak antagonist activityMicroiontophoretic studyMicroiontophoretic techniquesSuperficial laminaeIontophoretic applicationLY171555Pharmacological characterizationInhibitory responsesMajority of cellsPharmacological characteristicsPharmacological profile