1997
Characterization of dopamine‐induced depolarization of prefrontal cortical neurons
Shi W, Zheng P, Liang X, Bunney B. Characterization of dopamine‐induced depolarization of prefrontal cortical neurons. Synapse 1997, 26: 415-422. PMID: 9215600, DOI: 10.1002/(sici)1098-2396(199708)26:4<415::aid-syn9>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsEffects of dopaminePFC neuronsDA agonistsPrefrontal cortexAtypical antipsychotic drug clozapinePrefrontal cortical neuronsRat brain slicesAntipsychotic drug clozapineWhole-cell recordingsPFC pyramidal cellsSynaptic blockadeDA receptorsBeta antagonistDA antagonistsSubstantia nigraCortical neuronsPyramidal cellsBrain slicesDrug clozapineCell recordingsNeuronsAntagonistNonspecific mechanismsDopamineDepolarization
1996
Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat
Goldstein L, Rasmusson A, Bunney B, Roth R. Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat. Journal Of Neuroscience 1996, 16: 4787-4798. PMID: 8764665, PMCID: PMC6579011, DOI: 10.1523/jneurosci.16-15-04787.1996.Peer-Reviewed Original ResearchConceptsAmygdala lesionsMonoaminergic systemsMetabolic activationAdrenocortical activationStress-induced freezing behaviorStress-induced exacerbationStress-induced freezingPosttraumatic stress disorderAnteromedial prefrontal cortexNorepinephrine metabolismMonoamine responseAfferent controlNeuroendocrine componentBilateral NMDAPFC dopamineSchizophrenic symptomsCentral nucleusMild stressPrefrontal cortexStress disorderPsychological stressLesionsDopamineStress activationUltrasonic vocalizations
1990
Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies
Moghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistVivo voltammetryExtracellular DA concentrationsMM GluDA outflowStriatal dopamineReceptor antagonistExtracellular dopamineRat striatumVivo dialysisMicrodialysis probeLocal applicationBasal levelsExtracellular concentrationPathophysiological conditionsVivo releaseDA concentrationDopamineL-glutamateField potentialsIonic changesSignificant increaseSelective microelectrodesDepressionStriatumAcute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study
Moghaddam B, Bunney B. Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study. Journal Of Neurochemistry 1990, 54: 1755-1760. PMID: 1969939, DOI: 10.1111/j.1471-4159.1990.tb01230.x.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexOutflow of dopamineRelease of dopamineNucleus accumbensAntipsychotic drugsPrefrontal cortexAcute effectsExtracellular levelsAtypical antipsychotic drug clozapineVivo microdialysis studyAtypical antipsychotic drugsEffects of sulpirideEffects of haloperidolAntipsychotic drug clozapineMicrodialysis studyVivo microdialysisDrug clozapineHaloperidolStriatumAccumbensCortexSulpirideExtracellular concentrationDopamineDrugsCharacterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum
Moghaddam B, Roth R, Bunney B. Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum. Neuroscience 1990, 36: 669-676. PMID: 2234405, DOI: 10.1016/0306-4522(90)90009-s.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexRat medial prefrontal cortexPrefrontal cortexCortical dopamineDopamine releaseChloral hydrate-anesthetized ratsBeta-carboline FG 7142Dopamine release processBasal releasePara-tyrosineVivo microdialysisDopamine levelsFG 7142Local perfusionExtracellular dopamineAlpha-methylExtracellular levelsFmol/StriatumPharmacological manipulationCortexBasal levelsMicrodialysisStimulation conditionsDopamineUtilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs
Moghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsDopamine systemNigrostriatal dopamine systemEffects of clozapineRelease of dopamineRat. 2Mesocortical dopamine systemAcute administrationVivo microdialysisMesotelencephalic systemNucleus accumbensPrefrontal effectPrefrontal cortexClozapineExtracellular concentrationDopamineHaloperidolMicrodialysisDrugsSulpirideMesolimbicStriatumAccumbensCortex
1989
Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine
Moghaddam B, Bunney B. Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine. Journal Of Neurochemistry 1989, 53: 652-654. PMID: 2568406, DOI: 10.1111/j.1471-4159.1989.tb07383.x.Peer-Reviewed Original ResearchConceptsPharmacological responsivenessNigrostriatal dopamine systemExtracellular dopamine levelsExtracellular fluidBasal outflowBasal releaseStriatal dopamineHigh calcium levelsVivo microdialysisIonic compositionDopamine levelsCalcium levelsDopamine systemPharmacological manipulationRinger's solutionPerfusionDopamineResponsivenessSolution altersAltersMicrodialysis
1988
Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine
Silva N, Bunney B. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European Journal Of Pharmacology 1988, 149: 307-315. PMID: 3409955, DOI: 10.1016/0014-2999(88)90661-9.Peer-Reviewed Original ResearchConceptsSensitive neuronsInput resistanceAdministration of DADA-sensitive neuronsSelective D2 antagonistPacemaker-like activityHigh input resistanceZona compactaDA actionD2 antagonistDopamine neuronsIntracellular recordingsFiring rateIntracellular studyNeuronsReversal potentialTissue slicesDopamineHyperpolarizationSulpirideAntagonistCompactaAdministration
1985
Dopamine
Grace A, Bunney B. Dopamine. 1985, 285-319. DOI: 10.1007/978-1-4684-4961-7_9.Peer-Reviewed Original ResearchCatecholamine systemsBrain DA systemsFluorescence histochemical techniqueHistochemical fluorescence techniqueBiosynthesis of norepinephrinePrecise anatomical localizationBrain dopamineDopaminergic neuronsStriatal dopamineParkinson's diseaseAnatomical localizationNeuronal populationsAnatomical locationBrain functionDA systemDopamineStudy of dopamineHistochemical techniquesNorepinephrineNeurophysiological analysisDiseaseNeuronsBrainProjection areaBiochemical data
1979
Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists
Skirboll L, Grace A, Bunney B. Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists. Science 1979, 206: 80-82. PMID: 482929, DOI: 10.1126/science.482929.Peer-Reviewed Original ResearchConceptsDopamine autoIntravenous apomorphineDopamine agonistsPostsynaptic receptorsCentral nervous systemSubstantia nigraDopaminergic cellsDifferential sensitivityDopamine cellsDopaminergic influenceCaudate nucleusLarge dosesCaudate cellsNervous systemActive neuronsBehavioral effectsElectrophysiological evidenceApomorphineAgonistsParadoxical behavioural effectsReceptorsDopamineCellsNeuronsDosesThe effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat
Skirboll L, Bunney B. The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat. Life Sciences 1979, 25: 1419-1433. PMID: 522610, DOI: 10.1016/0024-3205(79)90420-x.Peer-Reviewed Original ResearchConceptsCaudate nucleusIontophoretic dopamineChronic HAL treatmentChronic haloperidol treatmentDifferent treatment regimensEffects of haloperidolDays of treatmentType IDrug terminationPostsynaptic supersensitivityHaloperidol treatmentTardive dyskinesiaTreatment regimensDaily dosesHAL treatmentSingle doseSpontaneous activitySupersensitive responseTreatment groupsType I unitsHaloperidolType II unitsInhibitory effectDopamineActive type I
1976
Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques
Bunney B, Aghajanian G. Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques. Life Sciences 1976, 19: 1783-1792. PMID: 1004134, DOI: 10.1016/0024-3205(76)90087-4.Peer-Reviewed Original ResearchConceptsRat prefrontal cortexMicroiontophoretic techniquesLayer VLayers IIPrefrontal cortexUptake blockersInhibitory effectNE uptake blockerDA receptor blockerCortical layers IIDA uptake blockersReceptor blockersDA inhibitionNoradrenergic projectionsAccumbens nucleusPharmacological differentiationNorepinephrineCell activitySensitivity of cellsHistochemical evidenceBlockersCortexDopamineSensitive cellsSuperficial layers
1973
Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones
BUNNEY B, AGHAJANIAN G, ROTH R. Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones. Nature 1973, 245: 123-125. PMID: 4518113, DOI: 10.1038/newbio245123a0.Peer-Reviewed Original ResearchConceptsDopamine receptorsAdjacent ventral tegmental areaL-DOPASubstantia nigra zona compactaFiring rateVentral tegmental areaAvailability of dopamineAromatic amino acid decarboxylaseDopamine-containing cellsAmount of dopamineComparison of effectsZona compactaTegmental areaD-amphetamineDopaminergic neuronesAmino acid decarboxylaseReceptor stimulationAcid decarboxylaseDopamineReceptorsApomorphineDrugsStimulationFeedback inhibitionCompacta