1997
Characterization of dopamine‐induced depolarization of prefrontal cortical neurons
Shi W, Zheng P, Liang X, Bunney B. Characterization of dopamine‐induced depolarization of prefrontal cortical neurons. Synapse 1997, 26: 415-422. PMID: 9215600, DOI: 10.1002/(sici)1098-2396(199708)26:4<415::aid-syn9>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsEffects of dopaminePFC neuronsDA agonistsPrefrontal cortexAtypical antipsychotic drug clozapinePrefrontal cortical neuronsRat brain slicesAntipsychotic drug clozapineWhole-cell recordingsPFC pyramidal cellsSynaptic blockadeDA receptorsBeta antagonistDA antagonistsSubstantia nigraCortical neuronsPyramidal cellsBrain slicesDrug clozapineCell recordingsNeuronsAntagonistNonspecific mechanismsDopamineDepolarization
1995
Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons.
Shi W, Nathaniel P, Bunney B. Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons. Journal Of Pharmacology And Experimental Therapeutics 1995, 274: 735-40. PMID: 7636736.Peer-Reviewed Original ResearchConceptsEffects of ritanserinBasal firing rateDA autoreceptorsDA neuronsDA agonistsP-chlorophenylalanineSubstantia nigra DA neuronsSingle-unit recording techniquesChloral hydrate-anesthetized ratsFiring rateDA agonist quinpiroleDirect DA agonistsIndirect DA agonistPostsynaptic D2 receptorsExtrapyramidal side effectsD2-like receptorsSignificant therapeutic effectAgonist-induced inhibitionMidbrain dopamine neuronsMidbrain dopamine systemAgonist quinpiroleDA antagonistsMDL 100907Receptor antagonistDopamine neurons
1987
Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin
Freeman A, Bunney B. Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin. Brain Research 1987, 405: 46-55. PMID: 3032350, DOI: 10.1016/0006-8993(87)90988-7.Peer-Reviewed Original ResearchConceptsCCK-8A9 neuronsDA neuronsDopaminergic neuronsUnrestrained ratsVentral tegmental area cellsFiring rateCCK-8 pretreatmentDA cell activitySingle dopaminergic neuronsEffects of apomorphineA10 dopaminergic neuronsActivity of A9Sulfated CCK-8A10 neuronsDA agonistsAnesthetized ratsParalyzed ratsSequential dosesA10 cellsCell activityCell firingUnit firingUnit activityApomorphine
1985
An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system
Clark D, Engberg G, Pileblad E, Svensson T, Carlsson A, Freeman A, Bunney B. An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system. Naunyn-Schmiedeberg's Archives Of Pharmacology 1985, 329: 344-354. PMID: 4033804, DOI: 10.1007/bf00496366.Peer-Reviewed Original ResearchConceptsPostsynaptic DA receptorsInhibitory actionDA autoreceptorsDA receptorsNeuronal activityDA cell firing rateExtracellular single-unit recordingsCaudate neuronal activityDA neuronal activityGallamine-paralyzed ratsNigrostriatal DA systemNigrostriatal dopamine systemSingle-unit recordingsCell firing rateReticulata neuronsDA agonistsDA cellsIntravenous administrationMajority of cellsDopamine systemN-propylpiperidineUnit recordingsPartial agonistCell activityFiring rateLow doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology
Grace A, Bunney B. Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology. Brain Research 1985, 333: 285-298. PMID: 3995296, DOI: 10.1016/0006-8993(85)91582-3.Peer-Reviewed Original ResearchConceptsDA cell firingDA cellsLow dosesInput resistanceDA agonistsReversal potentialStriatonigral pathwayCell firingCell firing rateElectrophysiological actionsApomorphine effectApomorphine administrationSlow depolarizationIntracellular recordingsIntravenous administrationDopamine cellsInhibitory inputsApomorphineStriatal cellsAction potentialsFiring rateAgonistsDosesCell dischargeCell electrophysiology
1977
Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies
Aghajanian G, Bunney B. Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives Of Pharmacology 1977, 297: 1-7. PMID: 193046, DOI: 10.1007/bf00508803.Peer-Reviewed Original ResearchConceptsDA neuronsDepressant effectDA agonist apomorphineWeak depressant actionSingle-cell recording studiesSingle-cell recordingsAgonist apomorphineDA agonistsMicroiontophoretic applicationMicroiontophoretic techniquesSubstantia nigraDepressant actionDopamine neuronsSingle dopamine neuronsPharmacological characterizationCatecholamine receptorsΒ-adrenoreceptorsCell recordingsCatecholamine agonistsRecording studiesNeuronsAutoreceptorsAntagonist trifluoperazineAgonistsSelective responsiveness