1989
The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons
Esposito E, Bunney B. The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons. European Journal Of Pharmacology 1989, 162: 109-113. PMID: 2656273, DOI: 10.1016/0014-2999(89)90609-2.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaVentral tegmental areaActive DA neuronsSCH 23390Chronic treatmentDA neuronsDopamine neuronsDepolarization blockSpontaneous activityDA receptor blockadeAcute subcutaneous injectionGroups of ratsMidbrain dopamine neuronsChronic haloperidolReceptor blockadeChronic administrationPars compactaTegmental areaAntipsychotic drugsSubcutaneous injectionChronic experimentsMarked reductionNeuronsTreatmentHaloperidol
1983
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
Chiodo L, Bunney B. Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. Journal Of Neuroscience 1983, 3: 1607-1619. PMID: 6135762, PMCID: PMC6564520, DOI: 10.1523/jneurosci.03-08-01607.1983.Peer-Reviewed Original ResearchConceptsExtrapyramidal side effectsDepolarization inactivationA10 neuronsAntipsychotic drugsDA neuronsDopaminergic neuronsSide effectsExtracellular single-unit recording techniquesExcitatory amino acid glutamateInhibitory neurotransmitter gamma-aminobutyric acidSingle-unit recording techniquesNeurotransmitter gamma-aminobutyric acidActive DA cellsA10 dopaminergic neuronsMidbrain dopaminergic neuronsGamma-aminobutyric acidActivity of A9Amino acid glutamateChronic administrationMicroiontophoretic applicationNeuroleptic treatmentNeuroleptic administrationAtypical neurolepticsTricyclic antidepressantsDA cells