Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder
Fesharaki-Zadeh A, Miyauchi JT, St. Laurent-Arriot K, Tsirka SE, Bergold PJ. Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder. ASN Neuro 2020, 12: 1759091420979567. PMID: 33342261, PMCID: PMC7755938, DOI: 10.1177/1759091420979567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningBrain Injuries, TraumaticComorbidityDisease Models, AnimalInflammationMaleMaze LearningMiceReflex, StartleStress Disorders, Post-TraumaticConceptsTraumatic brain injuryPost-traumatic stress disorderChi groupBrain injuryBarnes mazeCo-morbid traumatic brain injuryMale C57/BL6 miceCognitive deficitsComorbid post-traumatic stress disorderC57/BL6 miceStress disorderClosed-head modelIba-1 levelsChronic variable stress modelActive place avoidancePlace avoidanceGreater cognitive deficitsNeuroinflammatory outcomesBasal anxiety levelsCVS groupSham treatmentBL6 miceBehavioral deficitsMouse modelKey underlying mechanism