2021
Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging
Arefin TM, Lee CH, White JD, Zhang J, Kaffman A. Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging. Bio-protocol 2021, 11: e4221. PMID: 34909442, PMCID: PMC8635841, DOI: 10.21769/bioprotoc.4221.Peer-Reviewed Original ResearchEarly life stressMagnetic resonance imagingMouse brainDiffusion magnetic resonance imagingMouse modelResonance imagingWhole-brain voxel-based analysisVoxel-based analysisClinical trialsPostnatal stressPreclinical studiesNeurological conditionsAdult miceEntire mouse brainStructural abnormalitiesBrain regionsMouse strainsBrain connectivityBrainLife stressTranslational utilityStructural connectivityRodentsMiceTranslational workWhite-Matter Repair as a Novel Therapeutic Target for Early Adversity
Islam R, Kaffman A. White-Matter Repair as a Novel Therapeutic Target for Early Adversity. Frontiers In Neuroscience 2021, 15: 657693. PMID: 33897364, PMCID: PMC8062784, DOI: 10.3389/fnins.2021.657693.Peer-Reviewed Original ResearchMyelin developmentWhite matter repairNovel therapeutic targetPre-clinical workNovel therapeutic interventionsNon-human primatesNew agentsTherapeutic targetAnimal modelsTherapeutic interventionsTranslational researchEarly adversityRecent mechanistic studiesMolecular mechanismsRodentsDiverse mammalian species
2020
The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents
Mingrone A, Kaffman A, Kaffman A. The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents. Frontiers In Neuroscience 2020, 14: 618593. PMID: 33390898, PMCID: PMC7773806, DOI: 10.3389/fnins.2020.618593.Peer-Reviewed Original ResearchEarly life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning
White JD, Arefin TM, Pugliese A, Lee CH, Gassen J, Zhang J, Kaffman A. Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning. ELife 2020, 9: e58301. PMID: 33259286, PMCID: PMC7725504, DOI: 10.7554/elife.58301.Peer-Reviewed Original ResearchConceptsEarly life stressSex-specific changesContextual freezing behaviorFronto-limbic connectivityLife stressHigh-resolution diffusion magnetic resonance imagingSex-specific mechanismsMagnetic resonance imagingNeuroanatomical alterationsPostnatal stressDiffusion magnetic resonance imagingMouse modelFronto-limbicResonance imagingModerate responseMalesTranslational workFemalesRodentsFreezing behaviorHuman imagingImagingHypoconnectivityInjurySystematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents
Wang D, Levine JLS, Avila-Quintero V, Bloch M, Kaffman A. Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents. Translational Psychiatry 2020, 10: 174. PMID: 32483128, PMCID: PMC7264128, DOI: 10.1038/s41398-020-0856-0.Peer-Reviewed Original ResearchConceptsOpen field testEarly life stressSystematic reviewEffects of MSEffects of ELSAnxiety-like behaviorDefensive behaviorAnxiogenic effectsMaternal separationRodent modelsRatsEarly adversityMiceAbility of MSLife stressLack of standardizationChildhood maltreatmentRodentsExploratory behaviorEffect sizeInconsistent resultsELS modelImportant differencesReviewMS protocol
2007
Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights
Kaffman A, Meaney MJ. Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights. Journal Of Child Psychology And Psychiatry 2007, 48: 224-244. PMID: 17355397, DOI: 10.1111/j.1469-7610.2007.01730.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArousalBehavior, AnimalBrainCognitionCritical Period, PsychologicalDNA MethylationEmotionsEpigenesis, GeneticFemaleGroomingHumansHypothalamo-Hypophyseal SystemMaleMaternal BehaviorMicePhenotypePrimatesRatsReceptors, NeurotransmitterSensory DeprivationSocial EnvironmentTouchConceptsDNA methylationFrequency of lickingParent-offspring interactionsPostnatal maternal carePromoter elementsGene expressionPostmitotic cellsMolecular insightsParental careBehavioral traitsFunctional consequencesImportant roleMolecular scaffoldsMethylationMaternal careNon-human primatesRecent rodent workBrain developmentExpressionNeurodevelopmental aspectsRodentsMammalsGenesPrimates