2020
Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning
White JD, Arefin TM, Pugliese A, Lee CH, Gassen J, Zhang J, Kaffman A. Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning. ELife 2020, 9: e58301. PMID: 33259286, PMCID: PMC7725504, DOI: 10.7554/elife.58301.Peer-Reviewed Original ResearchConceptsEarly life stressSex-specific changesContextual freezing behaviorFronto-limbic connectivityLife stressHigh-resolution diffusion magnetic resonance imagingSex-specific mechanismsMagnetic resonance imagingNeuroanatomical alterationsPostnatal stressDiffusion magnetic resonance imagingMouse modelFronto-limbicResonance imagingModerate responseMalesTranslational workFemalesRodentsFreezing behaviorHuman imagingImagingHypoconnectivityInjury
2011
Affiliative Behavior Requires Juvenile, But Not Adult Neurogenesis
Wei L, Meaney MJ, Duman RS, Kaffman A. Affiliative Behavior Requires Juvenile, But Not Adult Neurogenesis. Journal Of Neuroscience 2011, 31: 14335-14345. PMID: 21976519, PMCID: PMC3204413, DOI: 10.1523/jneurosci.1333-11.2011.Peer-Reviewed Original ResearchConceptsAdult female miceAdult neurogenesisFemale miceSubventricular zoneAblation of neurogenesisLevels of neurogenesisTransgenic mouse approachSubgranular zoneOlfactory deficitsNew neuronsGlobal eliminationBrain circuitsNeurogenesisProfound impairmentMiceJuvenile periodNovel roleAdult femalesSocial explorationMouse approachSocial abnormalitiesMolecular mechanismsAblationFemalesPeriod